2021
DOI: 10.1007/s40487-021-00151-7
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Recommendations for Specimen and Therapy Selection in Colorectal Cancer

Abstract: Introduction Next-generation sequencing has emerged as a clinical tool for the identification of actionable mutations to triage advanced colorectal cancer patients for targeted therapies. The literature is conflicted as to whether primaries or their metastases should be selected for sequencing. Some authors suggest that either site may be sequenced, whereas others recommend sequencing the primary, the metastasis, or even both tumors. Here, we address this issue head on with a meta-analysis and pro… Show more

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