Recommendations on the use of ruxolitinib for the treatment of myelofibrosis

Devos, Timothy; Selleslag, Dominik; Zachée, Pierre; Benghiat, Fleur Samantha

doi:10.1080/10245332.2017.1385192

Cited by 2 publications

(1 citation statement)

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“…Bone marrow aspiration and biopsy are necessary for the diagnosis of progression, as secondary MF is classically distinguished from ET by the presence of reticulin or collagen fibers and megakaryocyte hyperplasia in the bone marrow [ 9 ]. This has therapeutic implications, as, for example, ruxolitinib, fedratinib, and parctitinibare have been approved for use in a first-line setting for intermediate and high-risk PMF and post ET and PV myelofibrosis but not for ET [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

A Case Report on Hepatic Extramedullary Hematopoiesis as the Manifestation of Progression to Secondary Myelofibrosis in a Patient with Essential Thrombocytopenia

et al. 2022

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Myeloproliferative neoplasms (MPN), which include primary myelofibrosis (PMF) and essential thrombocytopenia (ET), are characterized by the clonal proliferation of mature blood cells as a result of the overactivation of the JAK/STAT pathway. Extramedullary hematopoiesis (EMH), a common complication of PMF, occurs due to the dysregulation of the bone marrow microenvironment. We report an interesting case of a 73-year-old female with a working diagnosis of ET who was found to have EMH in the liver on biopsy after she had newly onset elevated liver enzymes and her ET had progressed to secondary myelofibrosis. We conclude that in patients with MPN who have rising liver enzymes, EMH in the liver should be part of the differential diagnosis. In addition, we believe that EMH is a sign of progression from MPN to secondary myelofibrosis and that it is imperative for performing bone marrow aspiration and biopsy in order to reassess hematopoiesis and to look for bone marrow fibrosis as well as evidence of progression.

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Section: Discussionmentioning

confidence: 99%