Recommended pre‐test counseling points for noninvasive prenatal testing using cell‐free DNA: a 2015 perspective

Sachs, Amy; Blanchard, Leah; Buchanan, Amanda; Norwitz, Errol R.; Bianchi, Diana W.

doi:10.1002/pd.4666

Cited by 76 publications

(64 citation statements)

References 40 publications

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“…To help healthcare professionals facilitate meaningful discussions between themselves and prospective parents, Sachs et al (2015) have developed a framework for pre-test counseling about NIPT, especially focusing on its capabilities and limitations. Participants in our study, however, felt that already in current screening practice, information and counseling were not up to standard.…”

Section: Discussionmentioning

confidence: 99%

What Do Parents of Children with Down Syndrome Think about Non‐Invasive Prenatal Testing (NIPT)?

Schendel

Kater-Kuipers

Vliet-Lachotzki³

et al. 2016

Journal of Genetic Counseling

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This study explores the attitudes of parents of children with Down syndrome towards non-invasive prenatal testing (NIPT) and widening the scope of prenatal screening. Three focus groups (n = 16) and eleven individual interviews with Dutch parents (and two relatives) of children with Down syndrome were conducted. Safety, accuracy and earlier testing were seen as the advantages of NIPT. Some participants were critical about the practice of screening for Down syndrome, but acknowledged that NIPT enables people to know whether the fetus is affected and to prepare without risking miscarriage. Many feared uncritical use of NIPT and more abortions for Down syndrome. Concerns included the consequences for the acceptance of and facilities for children with Down syndrome, resulting in more people deciding to screen. Participants stressed the importance of good counseling and balanced, accurate information about Down syndrome. Testing for more disorders might divert the focus away from Down syndrome, but participants worried about “where to draw the line”. They also feared a loss of diversity in society. Findings show that, while parents acknowledge that NIPT offers a better and safer option to know whether the fetus is affected, they also have concerns about NIPT’s impact on the acceptance and care of children with Down syndrome.

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Section: Discussionmentioning

confidence: 99%

What Do Parents of Children with Down Syndrome Think about Non‐Invasive Prenatal Testing (NIPT)?

Schendel

Kater-Kuipers

Vliet-Lachotzki³

et al. 2016

Journal of Genetic Counseling

View full text Add to dashboard Cite

show abstract

“…Since April 2014, NIPT is offered as an alternative option to invasive testing for pregnant women at increased risk of having a child with trisomy 21, 18 or 13 based on the first trimester combined test (cut‐off 1:200) or because of a previous child with these trisomies . Pre‐ and post‐test counseling is part of the program in order to enhance autonomous decision making . In the first year of the study, around 3000 tests were performed.…”

Section: Topics That (Pregnant) Women (Or Their Partner/relative) Andmentioning

confidence: 99%

What do people want to know about NIPT? Content analysis of questions emailed to national NIPT information websites

et al. 2017

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What's already known about this topic? Several countries, including the Netherlands, have implemented non‐invasive prenatal testing (NIPT) in their national prenatal screening programAccess to relevant online health information is important as it increases informed decision makingWhat does this study add? Visitors of national NIPT websites mostly request more information about testing beyond the currently available NIPT: a broader range of disorders (such as monogenic disorders) and increasing target group eligibility (such as low‐risk or twin pregnancies) © 2017 The Authors. Prenatal Diagnosis published by John Wiley & Sons, Ltd.

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“…The ability to make an informed choice has been shown to be associated with beneficial psychological outcomes such as less decisional conflict regarding the choice 11, 12. To safeguard the process of informed decision‐making, the need for comprehensive counseling on NIPT has been emphasized 9, 13…”

Section: Introductionmentioning

confidence: 99%

Trial by Dutch laboratories for evaluation of non‐invasive prenatal testing. Part II—women's perspectives

et al. 2016

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ObjectiveTo evaluate preferences and decision‐making among high‐risk pregnant women offered a choice between Non‐Invasive Prenatal Testing (NIPT), invasive testing or no further testing.MethodsNationwide implementation study (TRIDENT) offering NIPT as contingent screening test for women at increased risk for fetal aneuploidy based on first‐trimester combined testing (>1:200) or medical history. A questionnaire was completed after counseling assessing knowledge, attitudes and participation following the Multidimensional Measure of Informed Choice.ResultsA total of 1091/1253 (87%) women completed the questionnaire. Of these, 1053 (96.5%) underwent NIPT, 37 (3.4%) invasive testing and 1 (0.1%) declined testing. 91.7% preferred NIPT because of test safety. Overall, 77.9% made an informed choice, 89.8% had sufficient knowledge and 90.5% had positive attitudes towards NIPT. Women with intermediate (odds ratio (OR) = 3.51[1.70–7.22], p < 0.001) or high educational level (OR = 4.36[2.22–8.54], p < 0.001) and women with adequate health literacy (OR = 2.60[1.36–4.95], p = 0.004) were more likely to make an informed choice. Informed choice was associated with less decisional conflict and less anxiety (p < 0.001). Intention to terminate the pregnancy for Down syndrome was higher among women undergoing invasive testing (86.5%) compared to those undergoing NIPT (58.4%) (p < 0.001).ConclusionsThe majority of women had sufficient knowledge and made an informed choice. Continuous attention for counseling is required, especially for low‐educated and less health‐literate women. © 2016 The Authors. Prenatal Diagnosis published by John Wiley & Sons, Ltd.

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Recommended pre‐test counseling points for noninvasive prenatal testing using cell‐free DNA: a 2015 perspective

Cited by 76 publications

References 40 publications

What Do Parents of Children with Down Syndrome Think about Non‐Invasive Prenatal Testing (NIPT)?

What Do Parents of Children with Down Syndrome Think about Non‐Invasive Prenatal Testing (NIPT)?

What do people want to know about NIPT? Content analysis of questions emailed to national NIPT information websites

Trial by Dutch laboratories for evaluation of non‐invasive prenatal testing. Part II—women's perspectives

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