Recommended vitamin D levels in the general population

Varsavsky, Mariela; Moreno, Pedro R.; Fernández, Antonio B.; Fernández, Inés Luque; Gómez, José Manuel; Rubio, Verónica Ávila; Martin, Allison; Berdonces, María Cortés; Cortés, Silvia Näf; Muñoz, Manuel Romero; García, Rebeca Reyes; Gimeno, Esteban Jódar; Torres, Manuel Muñoz

doi:10.1016/j.endien.2016.11.003

Cited by 16 publications

(20 citation statements)

References 47 publications

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“…Vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] < 20 ng/mL) [ 3 , 4 , 5 ] is a major public health concern that is widespread among the general population and highly prevalent in pregnant women; it is found in 60% of them [ 6 , 7 , 8 , 9 ]. Maintaining serum concentrations between 30 and 50 ng/mL is recommended to achieve the health benefits of vitamin D [ 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…A low level of vitamin D during the pregnancy and special attention during the early stage of pregnancy produce less bone mineral content in the fetal skeleton. Calcitriol cord blood concentrations tend to be lower than those found in maternal serum [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ] due to the fact that calcitriol cannot easily cross the placental barrier [ 24 , 25 ], and parathyroid hormone concentrations are low in the fetus [ 26 ]. The high levels of phosphorus and calcium concentrations found in serum also contribute to lower fetal calcitriol concentrations because these factors suppress the expression of renal 25OHD-1-α-hydroxylase (CYP27B1) in the fetus [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D-Related Risk Factors for Maternal Morbidity during Pregnancy: A Systematic Review

Morales-Suárez-Varela

Uçar

Peraita-Costa

et al. 2022

Nutrients

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Vitamin D has well-defined classical functions related to metabolism and bone health but also has non-classical effects that may influence pregnancy. Maternal morbidity remains a significant health care concern worldwide, despite efforts to improve maternal health. Nutritional deficiencies of vitamin D during pregnancy are related to adverse pregnancy outcomes, but the evidence base is difficult to navigate. The primary purpose of this review is to map the evidence on the effects of deficiencies of vitamin D on pregnancy outcome and the dosage used in such studies. A systematic search was performed for studies on vitamin D status during pregnancy and maternal outcomes. A total of 50 studies came from PubMed, 15 studies came from Cochrane, and 150 studies came from Embase, for a total of 215 articles. After screening, 34 were identified as candidate studies for inclusion. Finally, 28 articles met the inclusion criteria, which originated from 15 countries. The studies included 14 original research studies and 13 review studies conducted between 2012 and 2021. This review was finally limited to the 14 original studies. This systematic review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, and the quality and strength of the evidence was evaluated using the Navigation Guide Systematic Review Methodology (SING). We found evidence that supports the idea that supplementary vitamin D for pregnant women is important for reducing the risk of gestational diabetes, hypertension, preeclampsia, early labor, and other complications. The data retrieved from this review are consistent with the hypothesis that adequate vitamin D levels might contribute to a healthy pregnancy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D-Related Risk Factors for Maternal Morbidity during Pregnancy: A Systematic Review

Morales-Suárez-Varela

Uçar

Peraita-Costa

et al. 2022

Nutrients

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“…The initial search yielded 561 references, 60 CGs were selected for full‐text review and 34 guidelines 46‐79 were included in the final analysis (Figure 1). These included 12 (35.3%) guidelines from Europe, 10 (29.4%) from North America, five (14.7%) from Asia, two (5.9%) from Oceania, two (5.9%) from South America and three (8.8%) from international organisations.…”

Section: Resultsmentioning

confidence: 99%

“…In the domains of AGREE II evaluated (Figure 2A, Table S2), the mean score was 59.4% (SD 18.3%) for “scope and purpose”, 39.4% (SD 21.1%) for “stakeholder involvement”, 32.3% (SD 20.2%) for “rigour of development”, 59.3% (SD 18.2%) for “clarity and presentation”, 27.4% (SD 18.7%) for “applicability”, 42.5% (SD 23.5%) for “editorial independence” and 44.5% (SD 17.5%) for the “overall rating”. As part of the AGREE II appraisal, the reviewers recommended four of the guidelines analysed (11.8%), 57,63,66,80 12 (35.3%) 47‐51,55,59‐61,71,75,76 were recommended with modifications, and 18 (52.9%) 46,52‐54,56,58,62,64,67‐70,72‐74,77‐79 were not recommended for use. Only three guidelines (8.8%) scored over 60% in “Rigour of development domain” and are considered high quality.…”

Section: Resultsmentioning

confidence: 99%

Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors

et al. 2021

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Background: Vitamin D has been widely promoted for bone health through supplementation and fortification of the general adult population. However, there is growing evidence that does not support these strategies. Our aim is to review the quality and recommendations on vitamin D nutritional and clinical practice guidelines and to explore predictive factors for their direction and strength. Methods:We searched three databases and two guideline repositories from 2010 onwards. We performed a descriptive analysis, a quality appraisal using AGREE II scores (Appraisal of Guidelines Research and Evaluation) and a bivariate analysis evaluating the association between direction and strength of recommendations, AGREE II domains' scores and pre-specified characteristics. Results:We included 34 guidelines, 44.1% recommended, 26.5% suggested and 29.4% did not recommend vitamin D supplementation. Guidelines that scored higher for "editorial independence" and "overall quality score" were less likely to recommend or suggest vitamin D supplementation (median 68.8 vs 35.4; P = .001 and 58.3

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“…Following the Endocrine Society Clinical Practice Guideline, the study population was divided into 3 groups according to the serum 25(OH)D 3 level: normal vitD 3 status (>30 ng/mL), insufficiency (20–30 ng/mL) and deficiency (<20 ng/mL) [ 9 ]. Alternative 25(OH)D 3 cut-offs were also explored, based on national recommendations and considering the existing controversies regarding the optimal 25(OH)D 3 level [ 18 , 19 ].…”

Section: Methodsmentioning

confidence: 99%

Association between Circulating Levels of 25-Hydroxyvitamin D3 and Matrix Metalloproteinase-10 (MMP-10) in Patients with Type 2 Diabetes

et al. 2022

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Background: Matrix metalloproteinase-10 (MMP-10) levels increase progressively starting from early diabetic kidney disease (DKD) stages. Vitamin D3 (vitD3) deficit is associated with a higher risk of diabetic microangiopathy. Reduced MMP-10 expression has been observed after exposure to vitD3. Aim: to assess how vitD3 status is related to MMP-10 levels in patients with Type 2 diabetes (T2D). Methods: 256 patients with T2D were included in this cross-sectional study. Demographic, clinical and serum MMP-10 and 25-hydroxyvitamin D3 (25(OH)D3) levels were collected from each patient. The association between MMP-10 and (25(OH)D3) levels was assessed using a correlation analysis and fitting a multivariate linear regression model. Results: Serum MMP-10 levels were inversely correlated with circulating 25(OH)D3 (rho = −0.25; p < 0.001). In the subgroup analysis this correlation was significant in patients with DKD (rho = −0.28; p = 0.001) and in subjects with vitD3 deficit (rho = −0.24; p = 0.005). In the regression model adjusted for kidney function, body adiposity, smoking and vitD supplementation MMP-10 levels were 68.7 pg/mL lower in patients with 25(OH)D3 > 20 ng/mL, with respect to 20 ng/mL (p = 0.006). Conclusions: vitD3 repletion status is an independent predictor of MMP-10 levels in T2D patients. Perhaps, high 25(OH)D3 values should be targeted in these patients in order to prevent vascular complications.

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Recommended vitamin D levels in the general population

Cited by 16 publications

References 47 publications

Vitamin D-Related Risk Factors for Maternal Morbidity during Pregnancy: A Systematic Review

Vitamin D-Related Risk Factors for Maternal Morbidity during Pregnancy: A Systematic Review

Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors

Association between Circulating Levels of 25-Hydroxyvitamin D3 and Matrix Metalloproteinase-10 (MMP-10) in Patients with Type 2 Diabetes

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