Reconstructing historical changes in the force of infection of dengue fever in Singapore: implications for surveillance and control

Egger, Joseph; Ooi, Eng Eong; Kelly, Dave; Woolhouse, Mark; Davies, Clive R.; Coleman, P. G.

doi:10.2471/blt.07.040170

Cited by 98 publications

(113 citation statements)

References 23 publications

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“…However, a wider sampling of viral isolates from neighboring geographic areas is needed to fully test this analysis. Furthermore, dengue epidemics in Singapore follow a regular 6-to 7-year periodic cycle, which is difficult to explain by patterns of viral evolution or by vector population density and might be more attributable to changing levels of herd immunity (6). In addition, in Colombia it has been observed that epidemic years are correlated with an increase in the infection rate of mosquitoes and not the total number of mosquitoes per household (18), indicating surveillance of mosquito populations may also be important in understanding epidemics.…”

Section: Resultsmentioning

confidence: 99%

Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore

Schreiber

Holmes

Ong

et al. 2009

J Virol

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Dengue is one of the most important emerging diseases of humans, with no preventative vaccines or antiviral cures available at present. Although one-third of the world's population live at risk of infection, little is known about the pattern and dynamics of dengue virus (DENV) within outbreak situations. By exploiting genomic data from an intensively studied major outbreak, we are able to describe the molecular epidemiology of DENV at a uniquely fine-scaled temporal and spatial resolution. Two DENV serotypes (DENV-1 and DENV-3), and multiple component genotypes, spread concurrently and with similar epidemiological and evolutionary profiles during the initial outbreak phase of a major dengue epidemic that took place in Singapore during 2005. Although DENV-1 and DENV-3 differed in viremia and clinical outcome, there was no evidence for adaptive evolution before, during, or after the outbreak, indicating that ecological or immunological rather than virological factors were the key determinants of epidemic dynamics.

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Section: Resultsmentioning

confidence: 99%

Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore

Schreiber

Holmes

Ong

et al. 2009

J Virol

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“…More recently, Cuba came close to eradicating Ae. aegypti in the 1980s (Kouri et al 1986) and Singapore has kept that mosquito down to very low levels for over 30 years, though dengue incidence has recently increased (Ooi et al 2006, Egger et al 2008. Beyond mosquitoes, the Onchocerciasis Control Programme in West Africa achieved its goals in 10 of 11 program countries (Amazigo and Boatin 2006).…”

Section: These New Technologies Includementioning

confidence: 99%

Sterile-Insect Methods for Control of Mosquito-Borne Diseases: An Analysis

Alphey

Benedict

Bellini

et al. 2010

Vector-Borne and Zoonotic Diseases

477

442

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Effective vector control, and more specifically mosquito control, is a complex and difficult problem, as illustrated by the continuing prevalence (and spread) of mosquito-transmitted diseases. The sterile insect technique and similar methods control certain agricultural insect pest populations in a species-specific, environmentally sound, and effective manner; there is increased interest in applying this approach to vector control. Such an approach, like all others in use and development, is not a one-size-fits-all solution, and will be more appropriate in some situations than others. In addition, the proposed release of pest insects, and more so genetically modified pest insects, is bound to raise questions in the general public and the scientific community as to such a method's efficacy, safety, and sustainability. This article attempts to address these concerns and indicate where sterileinsect methods are likely to be useful for vector control.

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“…Increased urbanization, international trade and travel disseminates both vector and viruses of dengue infection. 4 The laboratory confirmation of dengue is challenging. Most appropriate tests to confirm the infection depend on the day of illness and whether the infection is primary or secondary.…”

Section: Introductionmentioning

confidence: 99%

Correlation of serological markers and thrombocytopenia in early diagnosis of dengue infection

Ingale¹,

Upadhye

Upadhye³

2018

Int J Res Med Sci

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Background: Dengue is an acute viral infection with fatal complications. To reduce the disease burden, early and specific diagnosis of dengue hemorrhagic fever or dengue shock syndrome with supportive therapy reduces morbidity and mortality. This study was undertaken to evaluate the efficacy of NS1 antigen and platelet count.Methods: A total of 200 serum samples were collected from clinically suspected cases of dengue fever. Serum samples were tested for NS1, IgM and IgG and correlated with the platelet count.Results: Out of 200 samples screened in our study, 100 (50%) were positive for dengue parameters, 100 (50%) were negative. Out of 100 positive cases, 95 (95%) cases were positive for NS1antigen either alone or in combination with antibodies. 84 (84%) cases were exclusively positive for NS1 antigen only. Primary infection (positive for NS1 Ag, IgM, NS1 + IgM) was seen in 99 (99%) cases and secondary infection (positive for IgG, NS1 + IgG, IgM + IgG, NS1+ IgM+ IgG) was seen in 1 case (1%). Out of 100 positive cases, thrombocytopenia was observed in 60 (60%) of patients while 40 (40%) had platelet count within normal range.Conclusions: Dengue is endemic to Indian subcontinent. Currently no specific antiviral therapy is available. Measuring platelet count and detecting the NS1 antigen plays a vital role in early diagnosis, management and implementing the control measures in community to avoid spread of dengue.

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Reconstructing historical changes in the force of infection of dengue fever in Singapore: implications for surveillance and control

Cited by 98 publications

References 23 publications

Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore

Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore

Sterile-Insect Methods for Control of Mosquito-Borne Diseases: An Analysis

Correlation of serological markers and thrombocytopenia in early diagnosis of dengue infection

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