Reconstruction of bladder function and prevention of renal deterioration by means of end‐to‐side neurorrhaphy in rats with neurogenic bladder

Abstract

End-to-side neurorrhaphy is a useful method for restoring bladder function and preventing renal injury in rats with NB.

A new bladder‐emptying method in females with neurogenic bladder: A randomized, phase II trial

“…These results are in agreement with data from the previous reports that showed bladder capacity gain due to the reduction of urinary loss . Experimental studies have also presented an improvement of bladder compliance after detrusor musculature distension …”

“…17,18 Experimental studies have also presented an improvement of bladder compliance after detrusor musculature distension. 12,19,20 The proportion of total adverse events in the ISRD group was approximately half of those found in the CIC group, while more than 50% of the patients in the ISRD group did not present any side effects. This result is in agreement with the data obtained in the pilot study 11 and with previous studies that idealized alternative devices to CIC.…”

“…Side effects and adverse events encountered at home or noted by the physician were also reported. Adverse events were defined by Common Terminology Criteria for Adverse Events considering the System Organ Class and individual descriptions . Events were categorized according to their level of severity, as follows: Mild: hematuria, skin excoriations, and/or avulsions of the device; Serious: Fistulas, calcifications, fragmentation of the device, and urinary retention due to obstruction.…”

“…Adverse events were defined by Common Terminology Criteria for Adverse Events considering the System Organ Class and individual descriptions. 12 Events were categorized according to their level of severity, as follows: Mild: hematuria, skin excoriations, and/or avulsions of the device; Serious: Fistulas, calcifications, fragmentation of the device, and urinary retention due to obstruction. In case of adverse events associated with the ISRD (technical difficulties, discomfort, pain, urinary leakage, anatomical anomalies, and signs of infection) the treatment was re-evaluated.…”

SCF/c-kit signaling pathway participates in ICC damage in neurogenic bladder

“…Although available approach has dramatically improved morbidities and mortalities related to the upper urinary tracts, current management efforts do not address the reorganization of the spinal reflexes which lead to detrusor hyperreflexia (DH) and detrusor sphincter dyssynergia (DSD). Besides, improvement of neurogenic bladder injury plays a preventive role in the deterioration of renal function [2]. Therefore, further studies on the molecular mechanisms and functions of NB development are still urgently needed.…”