Reconstruction of the Lateral Mandibular Defect

Shnayder, Yelizaveta; Lin, Derrick T.; Desai, Shaun C.; Nussenbaum, Brian; Sand, Jordan P.; Wax, Mark K.

doi:10.1001/jamafacial.2015.0825

Cited by 36 publications

(36 citation statements)

References 30 publications

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“…Jawbone defect reconstruction that restores bone continuity and allows for dental rehabilitation remains a challenge for surgeons (Shen et al, ; Shnayder et al, ; Zhang et al, ). The achievement and maintenance of implant osseointegration in a predictable way is one of the most important aspects for successful use of implants to repair jawbone defects.…”

Section: Discussionmentioning

confidence: 99%

“…Jawbone defect reconstruction that restores bone continuity and allows for dental rehabilitation remains a challenge for surgeons (Shen et al, 2017;Shnayder et al, 2015;Zhang et al, 2015). The achieve- (Hu et al, 2016;Liu et al, 2014), IMC is fabricated via a biomimetic strategy to achieve properties that mimic those of native bone (Feng et al, 2016;Lian et al, 2013;Liao et al, 2004;Qiu et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Jawbone defects can result from trauma, osteomyelitis, tumor resection, or a congenital malformation and can create significant facial deformities that affect patients’ quality of life and cause a socioeconomic burden (Mizukami, Hyodo, Fukamizu, & Mineta, ; Shnayder et al, ; von Wilmowsky et al, ). Because jawbone defects are often accompanied by the loss of teeth, the objectives of jawbone reconstruction include not only restoring the anatomical height and contour of the missing part, but also achieving the maximum possible functionality for dental rehabilitation, which poses a great challenge for surgeons (Shen et al, ; Shnayder et al, ; Zhang et al, ). In past decades, methods using vascularized or non‐vascularized free flaps with simultaneous or delayed implant placement for jawbone defect reconstruction have been developed as a standard treatment modality (Chang, Coskunfirat, Wei, Tsai, & Lin, ; Pauchet, Pigot, Chabolle, & Bach, ; Shen et al, ; Shnayder et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Because jawbone defects are often accompanied by the loss of teeth, the objectives of jawbone reconstruction include not only restoring the anatomical height and contour of the missing part, but also achieving the maximum possible functionality for dental rehabilitation, which poses a great challenge for surgeons (Shen et al, ; Shnayder et al, ; Zhang et al, ). In past decades, methods using vascularized or non‐vascularized free flaps with simultaneous or delayed implant placement for jawbone defect reconstruction have been developed as a standard treatment modality (Chang, Coskunfirat, Wei, Tsai, & Lin, ; Pauchet, Pigot, Chabolle, & Bach, ; Shen et al, ; Shnayder et al, ). However, donor site morbidity remains a major disadvantage of this approach.…”

Section: Introductionmentioning

confidence: 99%

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Osseointegration effect of biomimetic intrafibrillarly mineralized collagen applied simultaneously with titanium implant: A pilot in vivo study

Zhang

et al. 2019

Clinical Oral Implants Res

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Objectives To investigate the promoting effects of biomimetic intrafibrillarly mineralized collagen (IMC) bone scaffold material on the osseointegration of a titanium implant simultaneously grafted into a critical‐sized bone defect as well as the underlying mechanisms involved. Materials and Methods A critical‐sized bone defect was created in the rat femur, and a titanium (Ti) implant surrounded by IMC or extrafibrillarly mineralized collagen (EMC) bone scaffold material was placed in the defect. A blank group and a natural bone group were included as controls. Osseointegration was assessed by micro‐computed tomographic, histological, and biochemical evaluations at 12 weeks postoperatively. Microarray technology was applied for transcriptional profile analysis at days 7 and 14 postoperatively. Results Significant bone regeneration and osseointegration were observed in the IMC and EMC groups according to μ‐CT and histological analyses. The bone volume (BV)/total volume (TV) fraction, bone‐to‐implant contact percentage, and bone area percentage as well as ultimate shear strength and maximal pull‐out force were all significantly higher in the IMC group than in the EMC group (all p < 0.05). Transcriptional analysis revealed overexpression of genes mainly associated with cell proliferation, immuno‐inflammatory response, skeletogenesis, angiogenesis, neurogenesis, and skeletogenesis‐related pathways during the early process of osseointegration in the IMC group. Conclusion Our data suggest that IMC placed simultaneously with a Ti implant may be a promising strategy in jawbone defect reconstruction. Several candidate genes that were found to be differentially expressed in the IMC group may be responsible for the superior osseointegration effects in this model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Osseointegration effect of biomimetic intrafibrillarly mineralized collagen applied simultaneously with titanium implant: A pilot in vivo study

Zhang

et al. 2019

Clinical Oral Implants Res

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“…Reconstruction of large defects in the lateral aspect of the mandible has provided comparable results with vascularised bone grafts, non-vascularised bone grafts (NVBGs) or with only soft-tissue flaps. [ 5 6 7 8 9 10 ] Hence, vascularised bone grafts in such situations are not proven to be significantly better than other modalities.…”

Section: Methodsmentioning

confidence: 99%

Defining giant mandibular ameloblastomas – Is a separate clinical sub-entity warranted?

Kanoi

Banerjee

Sundaramurthy

et al. 2018

Indian J Plast Surg

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Context:The term giant mandibular ameloblastoma (GMAs) while being in popular usage in the medical literature remains largely equivocal. Although a few authors have in the past attempted to ascribe definite criteria to this entity, these are by and large arbitrary and without any benefit in decision-making or contributing to its management.Aims:The aim of this study is to propose a set of objective criteria for GMAs that can be clinically correlated and thereby aid in the management of this entity.Patients and Methods:Of a total of 16 patients with ameloblastoma of the mandible presenting at our institute from August 2012 to September 2016, 11 patients were identified as having GMAs as per the criteria proposed.Results:The defects in the mandible following segmental resection ranged from 7 to 11.5 cm in length (mean: 9.3 cm). No clinical or radiological evidence of tumour recurrence was found during a mean follow-up period of 10.7 months (range: 2–28 months).Conclusions:Defining GMA based on objective inclusion and exclusion criteria allows segregation of these lesions, thereby helping to remove ambiguity, simplify decision-making and facilitate communication among treating reconstructive surgeons. Inclusion criteria include: (i) The segmental bone defect following resection with a minimum 1 cm margin of healthy bone should exceed 6 cm (ii) The segmental bone defect should involve the central mandibular segment.

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Oncology‐Related Defects in Mandible

2018

Diseases and Conditions in Dentistry

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Reconstruction of the Lateral Mandibular Defect

Cited by 36 publications

References 30 publications

Osseointegration effect of biomimetic intrafibrillarly mineralized collagen applied simultaneously with titanium implant: A pilot in vivo study

Osseointegration effect of biomimetic intrafibrillarly mineralized collagen applied simultaneously with titanium implant: A pilot in vivo study

Defining giant mandibular ameloblastomas – Is a separate clinical sub-entity warranted?

Oncology‐Related Defects in Mandible

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