Recovery from sublethal damage during intermittent exposures in cultured tumor cells: implications for dose modification in radiosurgery and imrt

Dosimetry comparison between volumetric modulated arc therapy with RapidArc and fixed field dynamic IMRT for local-regionally advanced nasopharyngeal carcinoma

“…Shibamoto, et al [19] showed that between two fractions of radiotherapy, sublethal repair occurred in 2-3 minutes or longer time, while using breast cancer cell strain EMT 6 and head and neck squamous cell strain SCCVn of mice in vitro.…”

Impact of Prolonged Fraction Delivery Times Simulating IMRT on Cultured Nasopharyngeal Carcinoma Cell Killing

“…They concluded that FDT in the range of 15 to 45 minutes may significantly decrease tumor cell killing and may have a significant impact on treatment outcome for tumors with a low a/b ratio and short repair half-time (T 1/2 ), such as prostate cancer. In addition, the negative effect of prolonged FDT was confirmed by some studies in vitro using cell lines with a low a/b ratio (11)(12)(13)(14)(15)(16). However, many human tumor cells have been reported to have a higher a/ b ratio around 10 (17)(18)(19).…”

Estimation of Errors Associated With Use of Linear-Quadratic Formalism for Evaluation of Biologic Equivalence Between Single and Hypofractionated Radiation Doses: An In Vitro Study

“…The characteristics of these cell lines have been previously described (15)(16)(17). Both cell lines were cultured in Eagle's minimum essential medium supplemented with 12.5% fetal bovine serum.…”