Recovery of Left Ventricular Function and Long-Term Outcomes in Patients with Takotsubo Syndrome: A Case Series

Abstract

AIM. The objective of this case series was to evaluate the recovery of left ventricular (LV) function and long-term outcomes in patients with Takotsubo Syndrome (TTS) and identify clinical predictors of major outcomes, including recurrence and complications. METHODS. This study included 32 patients diagnosed with TTS. Baseline characteristics, cardiac biomarkers, and electrocardiographic findings were documented. LV function, wall motion abnormalities, recurrence, complications, and quality of life were assessed at baseline, 3 months, 6 months, and 1 year. Logistic regression analysis was used to identify predictors of LV recovery and long-term complications. RESULTS. The mean age was 68 ± 10 years, with 90.6% of patients being female. LVEF improved from 35% ± 10% at baseline to 60% ± 5% at 1 year. Wall motion abnormalities resolved in 93.8% of patients, while recurrence of TTS occurred in 3.1% at 1 year. Younger age (< 65 years) and initial LVEF ≥ 30% were associated with better LV recovery. Emotional stress triggers and hypertension were significant predictors of long-term complications. Quality of life improved from 0.45 ± 0.15 to 0.85 ± 0.07 in 1 year, with a 96.9% survival rate. CONCLUSION. TTS patients generally experience favorable outcomes with significant LV recovery. Emotional stress and hypertension predict long-term complications, while younger age and higher initial LVEF indicate better recovery.