Recovery of stromal stem cells in bone sarcoma patients after chemotherapy: Implication for cell-based therapy in bone defect reconstruction

Beccheroni, Amira; Lucarelli, Enrico; Donati, Davide María; Sangiorgi, Luca; Capponcelli, Silvia; Gorini, Marco; Bertoja, Annarosa Zambon; Giardino, Roberto; Mercuri, Mario; Ferrari, Stefano; Bacci, Gaetano; Picci, Piero

doi:10.3892/or.10.4.891

Cited by 3 publications

(3 citation statements)

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“…For past so many years stem cells have been used in the replenishment of blood and immune system damage during treatment of cancer by chemotherapy or radiotherapy. [ 30 ]…”

Section: Stem Cell Therapy In Oral Mucosal Lesionsmentioning

confidence: 99%

Stem cell therapy: A novel treatment approach for oral mucosal lesions

2015

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Stem cells have enormous potential to alleviate sufferings of many diseases that currently have no effective therapy. The research in this field is growing at an exponential rate. Stem cells are master cells that have specialized capability for self-renewal, potency and capability to differentiate to many cell types. At present, the adult mesenchymal stem cells are being used in the head and neck region for orofacial regeneration (including enamel, dentin, pulp and alveolar bone) in lieu of their proliferative and regenerative properties, their use in the treatment of oral mucosal lesions is still in budding stages. Moreover, there is scanty literature available regarding role of stem cell therapy in the treatment of commonly seen oral mucosal lesions like oral submucous fibrosis, oral lichen planus, oral ulcers and oral mucositis. The present review will focus on the current knowledge about the role of stem cell therapies in oral mucosal lesions and could facilitate new advancements in this area (articles were obtained from electronic media like PubMed, EBSCO, Cochrane and Medline etc., from year 2000 to 2014 to review the role of stem cell therapy in oral mucosal lesions).

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“…For past so many years stem cells have been used in the replenishment of blood and immune system damage during treatment of cancer by chemotherapy or radiotherapy. [ 30 ]…”

Section: Stem Cell Therapy In Oral Mucosal Lesionsmentioning

confidence: 99%

Stem cell therapy: A novel treatment approach for oral mucosal lesions

2015

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“…This technique has particular implications in bone tumours as reconstruction of bone following chemotherapy and surgery is always a major problem. The stromal stem cells derived from bone marrow have been used in the cell-based bone reconstruction following chemotherapy and surgery in osteosarcoma and Ewing sarcoma[61]. Jager et al have shown the regeneration of osteoblasts from the survived mesenchymal progenitor cells following COSS-96 (the cooperative osteosarcoma study) polychemotherapy in vitro and its potential in vivo use [62].…”

Section: Stem Cells In Tissue Regeneration and As Delivery Vehiclesmentioning

confidence: 99%

Role of stem cells in cancer therapy and cancer stem cells: a review

et al. 2007

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For over 30 years, stem cells have been used in the replenishment of blood and immune systems damaged by the cancer cells or during treatment of cancer by chemotherapy or radiotherapy. Apart from their use in the immuno-reconstitution, the stem cells have been reported to contribute in the tissue regeneration and as delivery vehicles in the cancer treatments. The recent concept of 'cancer stem cells' has directed scientific communities towards a different wide new area of research field and possible potential future treatment modalities for the cancer. Aim of this review is primarily focus on the recent developments in the use of the stem cells in the cancer treatments, then to discuss the cancer stem cells, now considered as backbone in the development of the cancer; and their role in carcinogenesis and their implications in the development of possible new cancer treatment options in future.

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“…At present, many methods are used to repair bone defects, including transplantation of autologous or allogeneic bone [1], stromal stem cells [3], and tissue engineering scaffold repairing. Bone transplantation has been widely used in clinical practice, with good results.…”

Section: Introductionmentioning

confidence: 99%

Reconstruction of Bone Defect Based on the Fusion of Osteoblasts and MSM/HA/PLGA Porous Scaffolds

Zheng

et al. 2020

Preprint

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Reconstruction of bone defect is one of the difficult problems in orthopedic treatment, and bone tissue scaffold implantation is the most promising direction of bone defect reconstruction. In this study, we used the combination of HA (Hydroxyapatite) and PLGA [Poly (lacticco-glycolic acid)] in the construction of polymer scaffolds, and introduced bioactive MSM (Methyl sulfonyl methane) into polymer scaffolds to prepare porous scaffolds. The osteoblasts, isolated and cultured in vitro, were seeded in the porous scaffolds to construct tissue-engineered scaffolds. Meanwhile, the model of rabbit radius defect was constructed to evaluate the biological aspects of five tissue-engineered scaffolds, which provided experimental basis for the application of the porous scaffolds in bone tissue engineering. The SEM characterization showed the pore size of porous scaffolds was uniform and the porosity was about 90%. The results of contact Angle testing suggested that the hydrophobic porous scaffold surface could effectively promote cell adhesion and cell proliferation, while mechanical property test showed good machinability. The results of drug loading and release efficiency of MSM showed that porous scaffolds could load MSM efficiently and prolong the release time of MSM. In vitro incubation of porous scaffolds and osteoblasts showed that the addition of a small quantity of MSM could promote the infiltration and proliferation of osteoblasts on the porous scaffolds. Similar results were obtained by implanting the tissueengineered scaffolds, fused with the osteoblasts and MSM/HA/PLGA porous scaffolds, into the rabbit radius defect, which provided experimental basis for the application of the MSM/HA/PLGA porous scaffolds in bone tissue engineering.

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Recovery of stromal stem cells in bone sarcoma patients after chemotherapy: Implication for cell-based therapy in bone defect reconstruction

Cited by 3 publications

References 0 publications

Stem cell therapy: A novel treatment approach for oral mucosal lesions

Stem cell therapy: A novel treatment approach for oral mucosal lesions

Role of stem cells in cancer therapy and cancer stem cells: a review

Reconstruction of Bone Defect Based on the Fusion of Osteoblasts and MSM/HA/PLGA Porous Scaffolds

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