Rectal complications in patients with carcinoma of the cervix treated with concomitant cisplatin and external beam irradiation with high dose rate brachytherapy: A dosimetric analysis

Rectal bleeding and its management after irradiation for uterine cervical cancer

“…Perez et al (30) found that doses calculated at specific points defined only with reference to the applicators also showed a strong correlation with complications. Both Clark et al (8) and Esche et al (31) indicated that the correlation between the doses calculated at the rectal point defined by the ICRU and the incidence of late rectal complications was significant. Van Lancker and Storme (32) reported a statistically significant correlation between complications and the reference volume defined with reference to the HDR brachytherapy applicators.…”

“…The incidence of moderate to severe rectal complications has been limited to within 8% (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). In a review by Fu and Phillips (3), the overall rectal complication rates were comparable between the HDR and low-doserate techniques.…”

“…Rectal bleeding is the most common symptom and is a chronic side effect of radiation-induced rectal complications (proctopathy). The incidence for mildto-severe rectal complications in high-dose-rate (HDR) brachytherapy ranges from 5% to 30% (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The reported risk factors for rectal complications include age, radiation dose to the rectum (cumulative dose from EBRT and ICRT), percentage of point A dose and total EBRT dose.…”

Comparisons between the KKU-Model and Conventional Rectal Tubes as Markers for Checking Rectal Doses during Intracavitary Brachytherapy of Cervical Cancer

“…The bladder and rectum injuries from high radiation doses leads to morbidity and poor quality of life (Eng et al, 2004). The main treatmen-related factors which influence late complications were brachytherapy dose rate, volume of irradiated rectum and overall rectum dose (Montanna and Fowler, 1989;Van Lanker and Storme, 1991;Clark et al, 1994;Hai-Meder et al, 1994). The total rectal dose must be kept as low as possible during ICBT to prevent rectal complications.…”

Dosimetric parameters that predict late rectal complications after curative radiotherapy in patients with uterine cervical carcinoma

“…Several investigators [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] previously demonstrated that various clinical and treatment-related parameters, including age, diabetes mellitus, disease stage, EBRT dose, fractionation of brachytherapy, Point A dose, and rectal dose, were correlated with late rectal complications (LRC). In particular, RT dose and volume are considered the most important parameters associated with LRC.…”