Rectification of polymer translocation through nanopores by nonchiral and chiral active particles

Fazli, Zahra; Naji, Ali

doi:10.1103/physreve.107.024602

Cited by 2 publications

(1 citation statement)

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“…This was followed by a number of studies reporting the scaling exponent for unbiased translocation; however, there is not a common consensus yet [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. There is also a rich literature regarding the effect of various system parameters such as viscosity, salt concentration, chaperons, the presence of crowders, the activity of these crowders, etc., on the dynamics of unbiased translocation [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ].…”

Section: Polymer Translocation: Highlights From Theoretical Developmentmentioning

confidence: 99%

Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges

Singh

Chauhan

Bharadwaj

et al. 2023

IJMS

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Various biological processes involve the translocation of macromolecules across nanopores; these pores are basically protein channels embedded in membranes. Understanding the mechanism of translocation is crucial to a range of technological applications, including DNA sequencing, single molecule detection, and controlled drug delivery. In this spirit, numerous efforts have been made to develop polymer translocation-based sequencing devices, these efforts include findings and insights from theoretical modeling, simulations, and experimental studies. As much as the past and ongoing studies have added to the knowledge, the practical realization of low-cost, high-throughput sequencing devices, however, has still not been realized. There are challenges, the foremost of which is controlling the speed of translocation at the single monomer level, which remain to be addressed in order to use polymer translocation-based methods for sensing applications. In this article, we review the recent studies aimed at developing control over the dynamics of polymer translocation through nanopores.

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