Recurrence rate and associated factors of borderline ovarian tumors in the south of Vietnam

Abstract

Aim This study aimed to determine the recurrence rate and related risk factors of borderline ovarian tumors (BOT). Methods We conducted a retrospective cohort study with 433 patients who were surgically treated for primary BOT at Tu Du Hospital from 11/2008 to 09/2015. We used the life table method to estimate the cumulative recurrence rate. We used the log–rank test and Cox proportional hazard model to determine recurrence‐associated factors. Results Median follow‐up time was 43 months (range: 3–105 months). Eighteen patients developed recurrence. The cumulative BOT recurrence rates at year 1, 2, 3 and 4 were 1.2% (95% confidence interval [CI] = 0.5–2.8), 3.0% (95% CI = 1.7–5.2), 4.6% (95% CI = 2.9–7.4), and 5.1% (95% CI = 3.2–8.0), respectively. In the final multivariate model, a higher recurrence rate was significantly associated with primary tumor stages (stage I vs stages II and III, hazards ratio [HR] = 4.44, 95% CI = 1.60–12.38), pre‐operative tumor's capsule rupture (HR = 4.14, 95% CI = 1.78–9.64), and cystectomy (HR = 5.33, 95% CI = 1.43–19.91). Conclusion The overall BOT recurrence rate in women in southern Vietnam was moderate. Primary tumor stage, capsule rupture, and cystectomy were main factors associated with BOT recurrence. Appropriate follow‐up strategies for patients with high‐risk factors are needed for early detection and management of recurrence.

Risk Factors for Recurrence of Borderline Ovarian Tumours after Conservative Surgery and Impact on Fertility: A Multicentre Study by the Francogyn Group

“…In our study, and as expected, an advanced FIGO stage was found to be a risk factor for recurrence of BOT after conservative surgery. This result is consistent with the literature, as many authors have shown that advanced FIGO stage (≥II) was a factor in recurrence risk and decreased recurrence-free survival after conservative treatment, even in the case of complete surgery [15,16,19,28,37,43,48,49]. The presence of implants was also a risk factor for recurrence of BOT in multivariate analysis.…”

258. Risk factors for recurrence of borderline ovarian tumors in France: A multicenter retrospective study by the francogyn group

“…Referring patients to an oncology center may allow us to optimize their management. Fauvet et al (27) Fauvet et al (18) Romagnolo et al (30)) Fauvet et al (10) Park et al (22) Zapardiel et al (31) Ewald-Riegler et al (23) Azuar et al (26) Bendifallah et al (9) Bendifallah et al (32) Helpman et al (19) Ouldamer et al (20) Delle Marchette et al (24) Vo et al (25) 2004…”