2006
DOI: 10.1892/0891-6640(2006)20[933:rrcoac]2.0.co;2
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Recurrence Rate, Clinical Outcome, and Cellular Proliferation Indices as Prognostic Indicators after Incomplete Surgical Excision of Cutaneous Grade II Mast Cell Tumors: 28 Dogs (1994–2002)

Abstract: The objectives of this study were to determine local recurrence rate, clinical outcome, and prognostic value of the number of argyrophylic nucleolar organizer regions (AgNORs), presence of proliferating cell nuclear antigen (PCNA), and number of Ki-67-positive nuclei after incomplete surgical excision of canine cutaneous grade II mast cell tumors (MCTs). This retrospective study included 30 MCTs in 28 dogs. Medical records were examined and follow-up information was obtained from owners and referring veterinar… Show more

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Cited by 37 publications
(80 citation statements)
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“…Local recurrence has been associated with a poor prognosis in cMCT 9,32,36,37 . This study support this association, because 6 of 10 cases (60%) of cMCT with infiltration at distant sites were locally recurrent.…”
Section: Discussionsupporting
confidence: 79%
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“…Local recurrence has been associated with a poor prognosis in cMCT 9,32,36,37 . This study support this association, because 6 of 10 cases (60%) of cMCT with infiltration at distant sites were locally recurrent.…”
Section: Discussionsupporting
confidence: 79%
“…The diagnosis of metastasis, following WHO guidelines, consists of the presence or absence of mast cells in sites of metastasis 6 . Many authors suggest that the presence of mast cells in regional lymph nodes, liver, spleen, or bone marrow is not definitively diagnostic for distant metastasis because mast cells can be present at these sites in dogs with nonneoplastic, reactive conditions 8,9,18 …”
Section: Discussionmentioning
confidence: 99%
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“…A two-tiered (Kiupel and others 2011) and a three-tiered grading system (Patnaik and others 1984) are both currently used. Numerous histopathological proliferation indices and markers have also been utilised in attempt to better determine the biological behaviour of a MCT: argyrophilic nucleolar-organising regions (Bostock and others 1989, Scase and others 2006, Webster and others 2007, 2008), B-cell lymphoma 2 (BCL-2) gene and protein expression (Vascellari and others 2013), Ki-67 (Abadie and others 1999, Scase and others 2006, Ozaki and others 2007, Webster and others 2007, 2008, Maglennon and others 2008), KIT staining pattern, presence of mutations in KIT or alterations in other receptor tyrosine kinases (Zemke and others 2002, Kiupel and others 2004, Webster and others 2007, 2008, Thompson and others 2015), minichromosome maintenance protein 7 (Berlato and others 2012), mitotic index (Bostock and others 1989, Sakai and others 2002, Elston and others 2007, Romansik and others 2007, Vascellari and others 2013, Van Lelyveld and others 2015), tumour suppressor in lung cancer 1 (Taylor and others 2010) and combinations of multiple markers or indices (Simoes and others 1994, Séguin and others 2006). …”
mentioning
confidence: 99%