“…A two-tiered (Kiupel and others 2011) and a three-tiered grading system (Patnaik and others 1984) are both currently used. Numerous histopathological proliferation indices and markers have also been utilised in attempt to better determine the biological behaviour of a MCT: argyrophilic nucleolar-organising regions (Bostock and others 1989, Scase and others 2006, Webster and others 2007, 2008), B-cell lymphoma 2 (BCL-2) gene and protein expression (Vascellari and others 2013), Ki-67 (Abadie and others 1999, Scase and others 2006, Ozaki and others 2007, Webster and others 2007, 2008, Maglennon and others 2008), KIT staining pattern, presence of mutations in KIT or alterations in other receptor tyrosine kinases (Zemke and others 2002, Kiupel and others 2004, Webster and others 2007, 2008, Thompson and others 2015), minichromosome maintenance protein 7 (Berlato and others 2012), mitotic index (Bostock and others 1989, Sakai and others 2002, Elston and others 2007, Romansik and others 2007, Vascellari and others 2013, Van Lelyveld and others 2015), tumour suppressor in lung cancer 1 (Taylor and others 2010) and combinations of multiple markers or indices (Simoes and others 1994, Séguin and others 2006). …”