Recurrence Rate in a Patient Treated with Colon Resection Followed by Chemotherapy in Comparison to a Patient Treated with Colon Resection without Chemotherapy

Abstract

Given that colon cancer is one of the most prevalent cancers worldwide, it is essential to employ strategies to try to reduce its incidence and recurrence rate. Though colon cancer is a sporadic disease in the vast majority of cases, multiple risk factors are linked to this disease, namely, obesity and cigarette smoking. Additionally, not many studies have been done in Saudi Arabia studying the recurrence rate of colon cancer. Therefore, we conducted a retrospective cohort study at King Khalid Hospital, King Abdulaziz Medical City, National Guard Health Affairs (NGHA), Jeddah, Saudi Arabia to investigate the recurrence rate of colon cancer in patients treated with complete colon resection followed by chemotherapy versus patients treated with colon resection alone via electronic and paper medical records. A total of 120 patients were included in this study; 61 were males (50.8%) and 59 were females (49.2%). According to our findings, the recurrence rate in patients who underwent surgical resection with adjuvant chemotherapy was 15.6% (n = 10), while the recurrence rate in patients with surgery alone was 21.4% (n = 12). Cancer recurrence is associated with significant morbidity and mortality. Therefore, further studies should be done to investigate the recurrence rate in patients with risk factors to identify and deal with the causes of recurrence.

Long non-coding RNA LINC00511 facilitates colon cancer development through regulating microRNA-625-5p to target WEE1

“…Screening colonoscopy is effectively applied in the diagnosis of CC due to its benefits in reducing death rate and survival duration [ 3 ]. In addition, surgical resection of the colon is a well-established therapy for CC, while adjuvant chemotherapy followed by surgery further reduces the recurrence rate of CC [ 4 ]. As to the high prevalence, it is critical to explore optimal agents to minimize the impacts induced by CC.…”

Increased CD3+, CD8+, or FoxP3+ T Lymphocyte Infiltrations Are Associated with the Pathogenesis of Colorectal Cancer but Not with the Overall Survival of Patients

“…However, clinical evidence suggests that the outcome of the disease varies significantly among patients within the same TNM stage [ 7 , 8 , 9 ]. This is particularly noticeable at TNM stage II, wherein one-third of all patients may still die of recurrent disease [ 10 , 11 ]. Contrarily, patients at TNM stage III may be cured of the disease by surgery alone [ 12 ].…”