Recurrent Anaphylaxis Due to Delayed Allergy to Mammalian Meat in a Patient with Mastocytosis

Brady, Sean P.; Novack, Deborah V.; Kulczycki, Anthony

doi:10.1016/j.jaci.2014.12.1608

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 A higher prevalence of venom sensitivity is reported in patients with mastocytosis and, 10 although not as common, severe reactions to foods are also reported in this population including reports of alpha-gal sensitivity. [11][12][13] Alpha-gal sensitivity has been reported mainly in adults over 50 years of age with non-B blood types. 5,14 In this study, we report the clinical and laboratory characteristics of six patients with alphagal sensitization identified among 70 patients referred with a diagnosis of IA, two of which were found to have a clonal mast cell disorder.…”

Section: Introductionmentioning

confidence: 99%

Identification of alpha‐gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis

Carter

Ruiz-Esteves

Workman

et al. 2017

Allergy

View full text Add to dashboard Cite

IgE antibodies (Ab) specific to galactose-α-1,3-galactose (alpha-gal) are responsible for a delayed form of anaphylaxis that occurs 3-6 hours after red meat ingestion. In a unique prospective study of seventy participants referred with a diagnosis of idiopathic anaphylaxis (IA), six (9%) were found to have IgE to alpha-gal. Upon institution of a diet free of red meat, all patients had no further episodes of anaphylaxis. Two of these individuals had indolent systemic mastocytosis (ISM). Those with ISM had more severe clinical reactions but lower specific IgE to alpha-gal and higher serum tryptase levels, reflective of the mast cell burden. The identification of alpha-gal syndrome in patients with IA supports the need for routine screening for this sensitivity as a cause of anaphylaxis, where reactions to alpha-gal are delayed and thus may be overlooked.

show abstract