Recurrent Aphthous Stomatitis: An Assessment of Antioxidant Levels in Plasma and Saliva

Jesija, J S; Gopal, Saraswathi; Skiel, Hugh P

doi:10.7860/jcdr/2017/29065.10624

Cited by 5 publications

(6 citation statements)

References 18 publications

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“…SOD protects the cell from damage instigated by superoxide (O 2 − ) and hydroxyl radical, release H 2 O 2 in the process. Whereas SOD drops the steady-state level of O 2 − , catalase and peroxidases do the same for H 2 O 2 (Jesija, 2017).…”

Section: Resultsmentioning

confidence: 94%

“…This activity can be attributed to a donation of hydrogen, to an electron reduction or direct scavenger effects. During the detoxi ication of increased H 2 O 2 by glutathione, consumption of chemically abridged GSH also rises (Jesija, 2017). Reka and Anuradha (2011) stated that tissue GSH levels are considerably abridged by oxidative stress and proposed that antioxidant defense impairment mechanisms could permit enhanced free radical prompted tissue damage.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Tagetes erecta flower and leaf extract gel on oxidative stress and antioxidant levels in oral ulcer condition

Lakshana¹,

Vijayalakshmi²,

Jayakumar³

et al. 2020

ijrps

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An oral ulcer is described by repeated or painful oral aphthae, in which oxidative stress apparently leads to its pathogenesis. The present study has been undertaken to evaluate the effects of fresh leaves and flowers of Tagetes erecta gel on oxidative stress and antioxidant levels on oral ulcer models in albino Wistar rats. The oral ulcer was induced by incision wound model and then treated with the Tagetes erecta flower and leaf extract gel for 7 days. The antioxidant activities of catalase (CAT), superoxide dismutase (SOD), the levels of glutathione (GSH) and malondialdehyde (MDA) were measured in rat buccal mucosal tissues. The antiulcer effects of Tagetes erecta leaf and flower extracts (2.5% and 5%) gel were intercompared with the standard drug, Triamcinolone. Ulcer induced rats exhibited elevated levels of MDA and reduced activity of SOD, GSH and CAT when compared to the control rats. The nonequilibrium levels of antioxidant were observed in rat mucosal tissues indicate that body’s antioxidant status was depleted with an oral ulcer. Tagetes erecta leaf and flower gel (5%) has been found to have higher significant antioxidant activity compared with ulcer induced rats by reducing the levels of MDA and by increasing the activities of SOD, GSH and CAT in response to oxidative stress due to induction of oral ulcers in a rat model. The findings thus justify the traditional use of Tagetes erecta to heal oral ulcer by increasing the antioxidant status and decreasing the free radical production.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Effect of Tagetes erecta flower and leaf extract gel on oxidative stress and antioxidant levels in oral ulcer condition

Lakshana¹,

Vijayalakshmi²,

Jayakumar³

et al. 2020

ijrps

View full text Add to dashboard Cite

show abstract

“…On the other hand, Gupta et al found a marked reduction of UA levels in the serum of OLP patients in comparison with controls (4.058 ± 1.31 vs. 5.28 ± 0.961 mg/dL) [35]. By contrast, an increased level of salivary UA has been observed in the majority of generalized pathologic conditions such as diabetes and cardiovascular disorders, which might explain the systemic oxidative stress [36–38], as opposed to changes of local nature. The increase in UA levels in these studies may constitute a compensatory antioxidative defense system of the entire human body aimed at preventing generalized oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between the Concentration of Salivary Tyrosine and Antioxidants in Patients with Oral Lichen Planus

Darczuk

Krzyściak

Bystrowska

et al. 2019

Oxidative Medicine and Cellular Longevity

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The diagnosis of oral lichen planus (OLP) is based on clinical examination and histopathological criteria. Noninvasive diagnostics of saliva may be considered as a confirmation of OLP diagnosis and a potential alternative to an invasive method. The objective of the present study was to evaluate the relationship between the level of tyrosine (Tyr) as well as antioxidants like uric acid (UA) and glutathione peroxidase (GPx) activity in the saliva of patients with OLP in comparison with the control group (healthy subjects without any oral changes). A total of 40 patients with OLP and 40 healthy volunteers were selected for the study based on the modified WHO diagnostic (clinical and histopathological) criteria. High-performance liquid chromatography (HPLC) was performed for Tyr concentration, while GPx activity and uric acid levels were determined by a colorimetric method. The concentrations of Tyr, UA, and GPx activity were statistically lowered in OLP patients compared to the control group. All examined parameters correlated strongly and positively with each other. Mean values of salivary UA concentrations differed between the groups of OLP patients (reticular and erosive forms) and controls (206.66 vs. 196.54 vs. 218.49 μmol/L, respectively, p = 0.001). A similar trend was demonstrated in salivary Tyr concentration which differed statistically between the study and control groups (0.08 vs. 0.07 vs. 0.13 μmol/L, respectively, p = 0.001). Determining of a relationship between the concentrations of Tyr, UA, and GPx activity may be useful in the prognosis of OLP. The HPLC method may be employed, as an additional noninvasive diagnostic procedure to screen OLP patients, during the routine diagnostics of salivary biochemical parameters such as aromatic amino acids.

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“…Recurrent aphthous stomatitis (RAS) is a common oral mucosa disorder that affects 20% of the population (14). The clinical features of RSA are recurrent attack and shallow, rounded, discrete, painful oral ulcers (15).…”

Section: Salivary Antioxidants and Recurrent Aphthous Stomatitismentioning

confidence: 99%

Salivary Antioxidants Role in Oral Health and Diseases (A Review Article)

Abadul Gabar Al-Halfi,

Sh. Al-Essa,

G. Fadil

2023

TJDS

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Background: Saliva is the first defense system of the body through its antioxidant status (total antioxidant capacity), which is either enzymatic or non-enzymatic antioxidants, which block the process of oxidation by neutralizing free radicals; therefore, the objective of this review is to evaluate the role of salivary antioxidant biomarkers in the diagnosis and monitoring of many oral and periodontal diseases and related systemic disorders. Method: We searched for articles published on PubMed and Google Scholar in the last 20 years and then filtered the mints 60 papers according to the following keywords: saliva, total antioxidant capacity (TAC) and oxidative stress (OS). Conclusion: Saliva samples can be beneficial in demonstrating oxidant-antioxidant balance in oral and systemic illnesses and may be a suitable sample type in the diagnosis and monitoring of many pathologies in the body.

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Recurrent Aphthous Stomatitis: An Assessment of Antioxidant Levels in Plasma and Saliva

Cited by 5 publications

References 18 publications

Effect of Tagetes erecta flower and leaf extract gel on oxidative stress and antioxidant levels in oral ulcer condition

Effect of Tagetes erecta flower and leaf extract gel on oxidative stress and antioxidant levels in oral ulcer condition

The Relationship between the Concentration of Salivary Tyrosine and Antioxidants in Patients with Oral Lichen Planus

Salivary Antioxidants Role in Oral Health and Diseases (A Review Article)

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