Recurrent chromosome aberrations in human lung squamous cell carcinomas

Viegas‐Péquignot, Evani; Flüry-Hérard, A.; Crémoux, H. De; Chlecq, C.; Bignon, J.; Dutrillaux, Bernard

doi:10.1016/0165-4608(90)90162-4

Cited by 30 publications

(25 citation statements)

References 30 publications

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“…Loss of chromosome 8 or 8p, loss of Y, and rearrangement of 5q were not common in PE compared to primary tumors (Lukeis et a]., 1990). Loss of 8 or 8p without gain of 8q, and loss of Y have been described predominantly in primary tumors (Lukeis et al, 1990;Miura et al, 1990;Viegas-Pequignot et al, 1990) and do not occur often in PE, which supports our observation. In L-46, there was also an increase in ploidy from near diploid to near triploid, but we did not generally observe more triploid PE compared to triploid primaries.…”

Section: Discussionsupporting

confidence: 92%

“…Rearrangement in the region lp10-p13 and loss of 3p are consistently reported in the NSCLC literature which includes 12 PE (5 direct and 7 cell lines) (Zech et al, 1985;Miura et al, 1990;Whang-Peng et al, 1991), and are probably irrespective of the metastatic status and site of tumor growth (Liang et a]., 1986;Fan and Li, 1987;Rey et al, 1987;Jin et al, 1988;Erdel et al, 1990;Lukeis et al, 1990;Viegas-Pequignot et al, 1990;Sozzi et al, 1991;Testa and Siegfried, 1992). Other abnormalities reported by one or more groups are loss and rearrangement of 6q, 1 lp, 15p, 17p, and 19 (Lukeis et al, 1990;Miura et al, 1990;Viegas-Pequignot et al, 1990;Whang-Peng et al, 1991;Testa and Siegfried, 1992).…”

Section: Discussionmentioning

confidence: 88%

“…Other abnormalities reported by one or more groups are loss and rearrangement of 6q, 1 lp, 15p, 17p, and 19 (Lukeis et al, 1990;Miura et al, 1990;Viegas-Pequignot et al, 1990;Whang-Peng et al, 1991;Testa and Siegfried, 1992).…”

Section: Discussionmentioning

confidence: 92%

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Chromosome abnormalities in non‐small cell lung cancer pleural effusions: Cytogenetic indicators of disease subgroups

Lukeis¹,

Ball²,

Irving³

et al. 1993

Genes Chromosomes & Cancer

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A cytogenetic study of pleural effusions (PE) containing metastatic or invasive tumor cells from 11 patients with non-small cell lung cancer (NSCLC) (3 squamous cell carcinomas [SQC] and 8 adenocarcinomas [ADC] including 1 giant cell variant) was performed to identify non-random chromosome abnormalities. Numerical abnormalities seen in > or = 30% of cases included gain of chromosomes 7 and 20, and loss of chromosomes 4, 9, 10, 13, 15, 16, 18, 19, 21, and 22. The most frequent structural abnormality involved rearrangement in 1p with breakpoints clustering at 1p10-p13. Other recurrent breakpoint regions, seen in > or = 30% of cases, occurred in chromosome region 3p10-p21, 3q11-q25, 6p11-p25, 6q13-q23, 7q11-q36, 9q32-q34, 11p11-p13, 11q13-q24, 13p/14p and/or 15p, 17p and 19p, with, in particular, apparent loss of 6q21-q27, 3p21-p26, 7q21-q22, 9p22-p24 (shortest regions of common overlap) and 17p. There was also recurrent gain of 1q23-q44, 8q13-q24, and 11q13-q23. These abnormalities were not restricted to a particular histological subtype, with the exception of +8 and a breakpoint in 9q32-q34, which were seen only in ADC. The 9q32-q34 breakpoint observed in 4 ADC PE (including 1 giant cell variant) represents a new observation in NSCLC. These findings, when compared to those reported for primary NSCLC indicate cytogenetic differences between the two which may be associated with pleural invasion of NSCLC.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 88%

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Chromosome abnormalities in non‐small cell lung cancer pleural effusions: Cytogenetic indicators of disease subgroups

Lukeis¹,

Ball²,

Irving³

et al. 1993

Genes Chromosomes & Cancer

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“…Our cytogenetic observations of loss of 13q are also consistent with frequent LOH involving R B I and other tumor suppressor loci in esophageal SCC (Boynton et al, 1991;Huang et al, 1992). We confirmed recurrent loss of 13q (Viegas-Pequignot et al, 1990) and 18q in SCCHN and in SCC of the female genital tract (Fig. 6).…”

Section: Loss Of Materialssupporting

confidence: 88%

Recurrent cytogenetic abnormalities in squamous cell carcinomas of the head and neck region

Dyke

Worsham

Drumheller

et al. 1994

Genes Chromosomes & Cancer

185

100

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We characterized the breakpoints, gains, and losses of chromosome material in squamous cell carcinomas of the head and neck region from 29 patients. Cell lines were karyotyped in 1/3 of cases, direct preparations or early in vitro harvests in 1/3, and both in 1/3 of cases. GTG-banding was employed in all cases, as were C-banding and RBG- and AgNOR-staining in most. Some tumors were near-diploid and others near-tetraploid, but many had mixed populations, with diploid, tetraploid, and octoploid subclones representing essentially the same karyotypic pattern. The most frequent changes were deletions. Losses affecting 3p13-p24, 5q12-q23, 8p22-p23, 9p21-p24, and 18q22-q23 ranged in frequency from 40% to 60% of tumors. Loss of the short arm of the inactive X occurred in 70% of tumors from female patients, and loss or rearrangement of the Y occurred in 74% of tumors from male patients. Loss of 18q appeared to be associated with short survival, as did the presence of multiple deletions. There was gain (2-5 extra copies) of 3q21-qter, 5p, 7p, 8q, and 11q13-q23 in 28-38% of tumors. Three tumors had an hsr involving 11q13-q21. Gain of material at 11q13 is postulated to be associated with amplification of the PRADI/CCND gene at that locus. A translocation between proximal 1p and either an acrocentric short arm or proximal 8p or 9p was observed in squamous cell carcinomas of the head and neck region but not in female genital tract tumors. No other abnormalities appeared to be site specific, suggesting a pattern of genetic evolution in squamous cell carcinoma that is independent of anatomic site.

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“…La cytogénétique des tu meurs peut apporter de précieux renseignements sur les étapes possibles. Certes l'analyse des cancers pul monaires humains se heurte à une difficulté majeure qui est une extrême variabilité des phénotypes et un degré très variable de la ploïdie [100], Les anomalies chromosomiques récurrentes, tous types histologi ques, sont rares à l'exception de la perte du segment 3p [101], il est donc difficile de se faire une idée syn thétique de l'histoire naturelle de la cancérisation comme ce peut être fait pour le colon, par exemple [102]. 11 reste, cependant, que seul le matériel humain peut indiquer la logique du comportement des cel lules tumorales, dans leur environnement et dans un contexte de grande instabilité génétique, propre à ré pondre à la pression de sélection du milieu, peut-être par le développement ultime des clones ayant perdu le contrôle offert par un «anti-oncogène» qui reste à identifier.…”

Section: Perspectives Et Conclusionunclassified

Cancérogénèse pulmonaire expérimentale

Massé

1990

Respiration

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Although they have been described in several species, lung cancers are rare cancers, occurring in old age. For this reason, experimental lung carcinogenesis is practically limited to short-living rodents, rats being the most frequently used; other species have not been shown to provide improved models for extrapolation to man although they may be useful for specific toxicokinetics of some xenobiotics. The aim of experimental lung carcinogenesis is to detect putative airborne carcinogens which may cause cancer in man. Compared to man, for similar cumulated exposure, there is a general trend for a given ultimate carcinogen to result in a high rate of tumor induction in rodents; this is due to deposition and clearance patterns, together with the distal location of tumors. A weak response in rats exposed to tobacco smoke only can be easily explained by basic toxicokinetics; rats exhibit a strong response to the promoting effect of tobacco smoke. In vitro transformation of animal and human lung cells is expected to be a key issue for the purpose of interspecies extrapolation

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Recurrent chromosome aberrations in human lung squamous cell carcinomas

Cited by 30 publications

References 30 publications

Chromosome abnormalities in non‐small cell lung cancer pleural effusions: Cytogenetic indicators of disease subgroups

Chromosome abnormalities in non‐small cell lung cancer pleural effusions: Cytogenetic indicators of disease subgroups

Recurrent cytogenetic abnormalities in squamous cell carcinomas of the head and neck region

Cancérogénèse pulmonaire expérimentale

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