Recurrent Corneal Hypertrophic Scar After Laser-Assisted Subepithelial Keratectomy With Mitomycin C Treatment

Kim, Jae-hyung; Kim, Myoung Joon; Kim, Dong Yoon; Kim, Jae Yong; Tchah, Hungwon

doi:10.1097/ico.0b013e3181e846bb

Cited by 8 publications

(10 citation statements)

References 20 publications

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“…145,146 In most cases, uncorrected visual acuity (UCVA) is not significantly improved at 6 months. 135,136 Bestcorrected visual acuity, however, is significantly improved at 2-, 6-, and 12-month time points in cases of mechanical/femtosecond flaps combined with PTK. 135,136 The aberrometric data demonstrate that improvement of visual acuity is correlated with an improvement of corneal transparency, corneal regularity, and optical quality.…”

Section: Superficial Keratectomymentioning

confidence: 98%

“…135,136 Bestcorrected visual acuity, however, is significantly improved at 2-, 6-, and 12-month time points in cases of mechanical/femtosecond flaps combined with PTK. 135,136 The aberrometric data demonstrate that improvement of visual acuity is correlated with an improvement of corneal transparency, corneal regularity, and optical quality. 136 Excimer PTK is used in the management of superficial and anterior stromal opacities to improve epithelial stability or visual acuity.…”

Section: Superficial Keratectomymentioning

confidence: 98%

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Corneal Edema and Opacification Preferred Practice Pattern®

et al. 2019

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Section: Superficial Keratectomymentioning

confidence: 98%

Section: Superficial Keratectomymentioning

confidence: 98%

Corneal Edema and Opacification Preferred Practice Pattern®

et al. 2019

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“…Of collagen types, type I is a major component of the normal corneal stroma [8]. In damaged cornea, myofibroblast synthesizes massive amount of heterogenous collagens and increment of other collagen subtypes can result in the opaqueness of damaged cornea [8,[18][19][20]. Levels of collagen type III and IV (COL3A1 and COL4A1) are typically escalated in damaged cornea and related to corneal haze formation [8,18,[21][22][23].…”

Section: Sp-8356 Suppresses the Synthesis Of Pathologic Collagen Subtypementioning

confidence: 99%

A Novel CD147 Inhibitor, SP-8356, Attenuates Pathological Fibrosis in Alkali-Burned Rat Cornea

Joung

Noh

Jung

et al. 2020

IJMS

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The corneal fibrotic responses to corneal damage often lead to severe corneal opacification thereby resulting in severe visual impairment or even blindness. The persistence of corneal opacity depends heavily on the activity of corneal myofibroblast. Myofibroblasts are opaque and synthesize a disorganized extracellular matrix (ECM) and thus promoting opacification. Cluster of differentiation 147 (CD147), a member of the immunoglobulin superfamily, is known to play important roles in the differentiation process from fibroblast to myofibroblast in damaged cornea and may therefore be an effective target for treatment of corneal opacity. Here, we examined the therapeutic efficacy of novel CD147 inhibiting verbenone derivative SP-8356 ((1S,5R)-4-(3,4dihydroxy-5-methoxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one) on corneal fibrosis. Topical SP-8356 significantly reduced corneal haze and fibrosis in the alkali-burned cornea. In detail, SP-8356 inhibited both alpha-smooth muscle actin (α-SMA) expressing myofibroblast and its ECM-related products, such as matrix-metalloproteinase-9 and collagen type III and IV. Similar to SP-8356, topical corticosteroid (prednisolone acetate, PA) also reduced the ECM-related products and opacification. However, prednisolone acetate failed to decrease the population of α-SMA-positive corneal myofibroblast. In conclusion, SP-8356 is capable enough to prevent corneal haze by preventing pathological fibrosis after severe corneal damage. Therefore, SP-8356 could be a potentially promising therapeutic drug for corneal fibrosis.

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“…12 MMC has been used in ophthalmological, orthopedic, and otolaryngological surgery due to its antifibrotic effect. [13][14][15] In this study, we aimed to evaluate whether or not MMC has an antifibrotic effect on TGF-β-induced PD in a rat model. To our knowledge, this is the first study evaluating the antifibrotic effect of MMC in PD.…”

Section: Introductionmentioning

confidence: 99%

The histopathological effects of intracavernosal mitomycin-C injection in a rat Peyronie's disease model

Kaya

Kïbar

Yılmaz

et al. 2017

CUAJ

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Introduction: We aimed to evaluate whether or not mitomycin-C (MMC) has an antifibrotic effect on transforming growth factor-beta (TGF-β)-induced Peyronie's disease (PD) in a rat model. Methods: Eighteen 12-week-old male Sprague-Dawley rats were divided into three groups: Group 1=TGF-β1 (n=7); Group 2=TGF-β1+MMC (n=7); and Group 3=Sham group (0.25 ml bovine serum albumin injected) (n=4). All groups were sacrificed on the sixth week of the procedure and their penises were excised. All penis specimens were evaluated semi-quantitatively and quantitatively with histochemical, immunohistochemistry, and image analysis.

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Recurrent Corneal Hypertrophic Scar After Laser-Assisted Subepithelial Keratectomy With Mitomycin C Treatment

Abstract: Recurrent corneal hypertrophic scar may be a rare complication after LASEK treatment with mitomycin C application.

Cited by 8 publications

References 20 publications

Corneal Edema and Opacification Preferred Practice Pattern®

Corneal Edema and Opacification Preferred Practice Pattern®

A Novel CD147 Inhibitor, SP-8356, Attenuates Pathological Fibrosis in Alkali-Burned Rat Cornea

The histopathological effects of intracavernosal mitomycin-C injection in a rat Peyronie's disease model

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