Recurrent croup and persistent laryngomalacia: Clinical resolution after supraglottoplasty

The Relationship between Croup and Gastroesophageal Reflux: A Systematic Review and Meta‐Analysis

“…10 Another study found that 90.9% reported improvement after treatment with ranitidine or omeprazole for an unknown duration, 3 and two studies reported improvement after an anti-reflux treatment regimen that was not described. 12,22 Additionally, one study showed improvement to upper airway symptoms after antireflux surgery. 22 As shown in Figure 4, meta-analysis of these results shows that 83.8% of patients treated for GERD showed improvement to recurrent croup symptoms, with I 2 = 0.…”

“…12,22 Additionally, one study showed improvement to upper airway symptoms after antireflux surgery. 22 As shown in Figure 4, meta-analysis of these results shows that 83.8% of patients treated for GERD showed improvement to recurrent croup symptoms, with I 2 = 0. Further analysis of combined data demonstrates that of the 154 patients with croup, 78 (49.4%) have laryngeal findings consistent with GERD.…”

“…Because GERD was not defined and an objective measure of improvement following anti-reflux treatment was not identified, this study was not included in this analysis. 22 One limitation of these studies is that only one, Hoa et al, clearly states the anti-reflux medication regimen (ranitidine + metoclopramide for 6-9 months) that led to improvement. 12 Another limitation is that these three studies do not mention recording adverse events related to anti-reflux medications and do not include a control group.…”

“…An additional study investigating six patients with recurrent croup and reflux reported an improvement in recurrent croup symptoms of four of the six patients. Because GERD was not defined and an objective measure of improvement following anti‐reflux treatment was not identified, this study was not included in this analysis 22 . One limitation of these studies is that only one, Hoa et al, clearly states the anti‐reflux medication regimen (ranitidine + metoclopramide for 6–9 months) that led to improvement 12 .…”

“…Specifically, one study found that 87.5% of patients reported improvement to croup symptoms after treatment with ranitidine and metoclopramide for a 6–9‐month course 10 . Another study found that 90.9% reported improvement after treatment with ranitidine or omeprazole for an unknown duration, 3 and two studies reported improvement after an anti‐reflux treatment regimen that was not described 12,22 . Additionally, one study showed improvement to upper airway symptoms after anti‐reflux surgery 22 .…”