Recurrent Facial Edema

If not angioedema, what is it? Diagnostic approach to facial edema

“…Cutaneous angiosarcoma is a rare, aggressive, malignant vascular neoplasm which occurs most commonly in elderly men and affects the head and neck 37 . It may present as nodules, plaques, or erythematous‐violaceous macules depending on the degree of infiltration; however, there are published cases in which the primary clinical manifestation are episodes of indurated, progressive, pitting facial edema, as opposed to classic angioedema 37,38 . Persistent facial edema is rare, but it is a diagnosis to consider.…”

“…Persistent facial edema is rare, but it is a diagnosis to consider. Histopathological examination is the definitive diagnosis 38 . Clinical differential diagnosis includes vascular tumors such as hemangioma or Kaposi's sarcoma, cutaneous lymphoma and pseudolymphoma, cutaneous metastases, or angiomatoid fibrohistiocytoma 37,38 .…”

“…Histopathological examination is the definitive diagnosis 38 . Clinical differential diagnosis includes vascular tumors such as hemangioma or Kaposi's sarcoma, cutaneous lymphoma and pseudolymphoma, cutaneous metastases, or angiomatoid fibrohistiocytoma 37,38 . Radical surgery followed by adjuvant radiotherapy is the treatment of choice in resectable cases.…”

“…Radical surgery followed by adjuvant radiotherapy is the treatment of choice in resectable cases. If the tumor is unresectable and/or there is metastatic disease, chemotherapy is the treatment of choice 38 …”

Wenn es kein Angioödem ist, was dann? Diagnostisches Vorgehen bei Gesichtsödemen

“…Je nach Infiltrationsgrad kann es sich als Knötchen, Plaques oder erythematös‐violette Hautflecken präsentieren. Es gibt jedoch veröffentlichte Fälle, in denen Episoden von verhärteten, progressiven, eindrückbaren Gesichtsödemen die primäre klinische Manifestation darstellen, im Gegensatz zu klassischen Angioödemen 37,38 . Anhaltende Gesichtsödeme sind selten, aber es ist eine Diagnose, die in Betracht gezogen werden sollte.…”