Recurrent Herpes Simplex Virus Labialis and the Use of Epidural Morphine in Obstetric Patients

Epidural opioid analgesia after Caesarean section: a comparison of patient-controlled analgesia with meperidine and single bolus injection of morphine

“…The fact that 13% of women using PCEA felt that the use of the PCA apparatus per se impeded their mobility may also have influenced the satisfaction score. The 4% incidence of recrudescence of herpes simplex labilalis in our patients who received epidural morphine is similar to the 3.5% incidence reported by Fuller, 4 although Crone et al 21 found the incidence to be as high as 9%. The risk of delayed respiratory depression following epidurai morphine administration is well documented, and has been estimated at 0.25%.…”

A Comparative Study Effect of Intrathaecal Tramadol (20mg) Use as Adjuvant With Hyperbaric Bupivacaine (15mg) and Hyperbaric Bupivacaine for Postoperative Analgesia in Infraumbilical Surgeries.

“…. However, pruritus, nausea, vomiting, urinary retention, activation of herpes labialis [8] and risk of unpredictable respiratory depression [9,10] have directed the clinicians to use a lower dose of tramadol that can be used intrathecally to produce effective and prolonged analgesia without such complications.…”

Epidural morphine for post-Caesarean analgesia

“…TM In a later prospective study, Crone et al 13 suggested the incidence was as high as nine per cent. In further work, having tried to eliminate confounding variables, such as the use of epinephrine and different local anaesthetics, Crone observed that almost 15 per cent of women developed cold sores, compared with none after IM morphine.…”

“…i1,12 Plus tard, dans une Etude prospective, Crone et al 13 ont suggErE que I'incidence Etait aussi haute que neuf pour cent. D'autres Etudes ont tentE d'Eliminer les variables qui am~nent ~ la confusion comme rutilisation de I'EpinEphrine et des agents anesthEsiques Iocaux diffErents, Crone observa qu'~ peu pros 15 pour cent des femmes ont dEveloppE des lesions d'herp/~s simplex orales comparativement h aucune apr~s radministration de morphine intramusculaire.…”