Recurrent Oral Ulcers

Stoopler, Eric T.; Sollecito, Thomas P.

doi:10.1001/jama.2015.1637

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…RAU is the most common oral mucosal ulcer disease ( 130 , 131 ). The immunological etiology of RAU is mainly cellular immunity.…”

Section: Th17 Cells In Oral Mucosal Immunitymentioning

confidence: 99%

Targeting Th17 cells: a promising strategy to treat oral mucosal inflammatory diseases

Wang¹,

Xue²,

Wang³

et al. 2023

Front. Immunol.

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With the improved quality of life, oral health is under increased pressure. Numerous common oral mucosal diseases, such as oral lichen planus(OLP) and gingivitis, are related to the destruction of the oral immune barrier. The cytokines secreted by T-helper 17 (Th17) cells are essential for maintaining oral immune homeostasis and play essential roles in immune surveillance. When antigens stimulate the epithelium, Th17 cells expand, differentiate, and generate inflammatory factors to recruit other lymphocytes, such as neutrophils, to clear the infection, which helps to maintain the integrity of the epithelial barrier. In contrast, excessive Th17/IL-17 axis reactions may cause autoimmune damage. Therefore, an in-depth understanding of the role of Th17 cells in oral mucosa may provide prospects for treating oral mucosal diseases. We reviewed the role of Th17 cells in various oral and skin mucosal systemic diseases with oral characteristics, and based on the findings of these reports, we emphasize that Th17 cellular response may be a critical factor in inflammatory diseases of the oral mucosa. In addition, we should pay attention to the role and relationship of “pathogenic Th17” and “non-pathogenic Th17” in oral mucosal diseases. We hope to provide a reference for Th17 cells as a potential therapeutic target for treating oral mucosal inflammatory disorders in the future.

show abstract

“…RAU is the most common oral mucosal ulcer disease ( 130 , 131 ). The immunological etiology of RAU is mainly cellular immunity.…”

Section: Th17 Cells In Oral Mucosal Immunitymentioning

confidence: 99%

Targeting Th17 cells: a promising strategy to treat oral mucosal inflammatory diseases

Wang¹,

Xue²,

Wang³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…3,4 The etiology and pathogenisis of RAS have not been very clear until now. An immunosuppressor, immunopotentiator, or sex hormone, as western medicines, were usually applied in the treatment of RAS, 5 but their long-term efficacy and sideeffects have not been satisfactorily determined yet. Traditional Chinese medicine (TCM) have shown special advantages in the treatment of RAS, and many effective prescriptions have been reported.…”

Section: Introductionmentioning

confidence: 99%