Recurrent white thrombi formation in hemodialysis tubing: a case report

Abstract

BackgroundWhile the appearance of red clots in the dialyzer is a common phenomenon in every hemodialysis unit, the occurrence of white thrombi in the tubing is relatively rare.Case presentationWe describe an adolescent male with recurrent white thrombi formation in the hemodialysis tubing. This patient had chronic renal failure from focal segmental glomerulosclerosis, but was no longer nephrotic at the time of the thrombi formation. He had a history of recurrent thrombosis of his vascular access. However, no pro-thrombotic risk factors could be identified. White particulate matter, measuring 1 to 3mm in size, and adherent to the arterial and venous blood tubing lines was found during the rinse back of a hemodialysis session. This was associated with a 60% decrease in his platelet count. Light microscopic examination of the deposits revealed the presence of platelet aggregates. He subsequently developed thrombosis of his arteriovenous graft six hours later. The white thrombi recurred at the next dialysis session, as well as six months later. These episodes occurred regardless of the type of dialysis machine or tubing, and appeared to resolve with an increase in heparin dose.ConclusionRecurrent white thrombi formation can occur in the hemodialysis tubing of a patient with no identifiable pro-thrombotic factors. The white thrombi may be a harbinger of arteriovenous graft thrombosis and may be prevented by an increase in heparin dose.

Ultrathin and Robust Hydrogel Coatings on Cardiovascular Medical Devices to Mitigate Thromboembolic and Infectious Complications

“…These complications are not unique to catheter devices, as they have also been reported for other blood-contacting devices such as stents, prosthetic bypass grafts, dialysis equipment, ventricular-assisted devices (VADs), artificial heart valves, and extracorporeal membrane oxygenation (ECMO) equipment. [17][18][19][20][21][22] Despite significant efforts, infectious and thromboembolic complications associated with the use of cardiovascular medical devices continue to represent a significant, unmet clinical challenge, especially given the increasing population of chronically ill patients that depend on these devices.…”