Recyclable nanoparticulate copper mediated synthesis of naphthoxazinones in PEG-400: a green approach

Kumar, Ajeet; Saxena, Amit; Dewan, Manika; De, Arnab; Mozumdar, Subho

doi:10.1016/j.tetlet.2011.07.016

Cited by 50 publications

(25 citation statements)

References 27 publications

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“…Our group has reported the use of nanoparticles in biomedical applications 37,38 and catalysis [39][40][41][42][43][44][45][46][47][48][49][50][51][52] in the past. Here we have demonstrated the use of gold nanoparticles for immobilization of urease, a technique that could potentially be used to immobilize other relevant proteins and bioactive peptides.…”

Section: Resultsmentioning

confidence: 99%

pH‐dependent immobilization of urease on glutathione‐capped gold nanoparticles

Garg

Mozumdar

2014

J Biomedical Materials Res

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Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Although the enzyme serves a significant role in several detoxification and analytical processes, its usability is restricted due to high cost, availability in small amounts, instability, and a limited possibility of economic recovery from a reaction mixture. Hence, there is a need to develop an efficient, simple, and reliable immobilization strategy for the enzyme. In this study, the carboxyl terminated surface of glutathione-capped gold nanoparticles have been utilized as a solid support for the covalent attachment of urease. The immobilization has been carried out at different pH conditions so as to elucidate its effect on the immobilization efficiency and enzyme bioactivity. The binding of the enzyme has been quantitatively and qualitatively analyzed through techniques like ultraviolet-visible spectroscopy, intrinsic steady state fluorescence, and circular dichorism. The bioactivity of the immobilized enzyme was investigated with respect to the native enzyme under different thermal conditions. Recyclability and shelf life studies of the immobilized enzyme have also been carried out. Results reveal that the immobilization is most effective at pH of 7.4 followed by that in an acidic medium and is least in alkaline environment. The immobilized enzyme also exhibits enhance activity in comparison to the native form at physiological temperature. The immobilized urease (on gold glutathione nanoconjugates surface) can be effectively employed for biosensor fabrication, immunoassays and as an in vivo diagnostic tool in the future.

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Section: Resultsmentioning

confidence: 99%

pH‐dependent immobilization of urease on glutathione‐capped gold nanoparticles

Garg

Mozumdar

2014

J Biomedical Materials Res

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“…GC-MS spectra were recorded using an Agilient 6890 N GC and 5973 mass selective detector using with an HP- [47,48] and 1-phenethyl- [49] used in this work as starting compounds were prepared by treating benzimidazole with (chloromethyl)benzene, 2-bromo-1-phenylethanone and (2-bromoethyl)benzene, respectively, according to a modified literature procedure (Scheme 1). Compounds 1 [46,48] and 10 [50] have been reported in the literature but their synthesis methods need multi-step reactions and long reaction times.…”

Section: Gc-ms Analysismentioning

confidence: 99%

Efficient and green catalytic system incorporating new benzimidazolium salts for the Sonogashira cross‐coupling reaction

Yavuz

Küçükbay

2017

Applied Organom Chemis

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A number of novel benzimidazole salts were synthesized and their structures were determined using 1 H NMR, 13 C NMR and infrared spectroscopic techniques and elemental analysis. A catalyst system consisting of Pd(OAc) 2 and copper nanoparticles in the presence of Cs 2 CO 3 and incorporating the novel benzimidazole salts in poly(ethylene glycol) solvent significantly improved the yields of Sonogashira reactions between aryl halides and phenylacetylene under microwave irradiation in 10 min.

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“…Also, Wang used this class of compounds as precursors in the preparation of chiral amino phosphine ligands for application in asymmetric catalysis [9]. However, to the best of our knowledge, only few reports exist on the synthesis of naphthalene-condensed oxazinone derivatives in the literature [8][9][10][11]. Recently, some derivatives of naphthalene-condensed 1,3-oxazin-3-ones were synthesized using condensation of amino alkylnaphthols in the presence of triethylamine [12].…”

Section: Introductionmentioning

confidence: 99%