Red Blood Cell Membrane Lipid Peroxidation in Continuous Ambulatory Peritoneal Dialysis Patients

Taccone-Gallucci, M; Giardini, O; Lubrano, Riccardo; Mazzarella, V.; Bandino, Donatella; Khashan, S; Mannarino, Olga; Elli, Marco; Cozzari, M; Buoncristiani, U; Casciani, Carlo Umberto

doi:10.1159/000167061

Cited by 28 publications

(14 citation statements)

References 5 publications

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“…Our data confirm that dialyzed patients are in a condition of oxidative stress (high values of plasma MDA-4HNE and ROMs, low plasma thiols) which is exacerbated by the dialytic session and which is less severe in PD patients. This latter finding has been reported previously [20, 21, 22, 23], and it may be due to the lack of contact of the blood with the dialysis membrane, to the absence of intravenous iron administration, and, perhaps, to the persistence of a residual renal function in PD patients.…”

Section: Discussionsupporting

confidence: 81%

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Oxidative Stress and Cardiovascular Disease in Dialyzed Patients

Usberti

Gerardi

Gazzotti

et al. 2002

Nephron

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Background/Aim: Oxidative damage has been suggested to play a key role in accelerated atherosclerosis and to be involved in cardiovascular disease (CVD) of dialyzed patients who are at risk of increased oxidative stress. The purpose of the present study was to examine the relationship between the severity of CVD and some markers of oxidative stress and antioxidant activity in our hemodialyzed (HD) and peritoneal dialysis (PD) patients. Methods: Plasma reactive oxygen metabolites, malondialdehyde and 4-hydroxynonenal (MDA-4HNE), thiols, α-tocopherol, and total antioxidant status (TAS) were measured in 55 HD and in 16 PD patients. CVD was considered as the result of variably combined cardiac, cerebral, and vascular pathologies which were scored and grouped in a single CVD index and analyzed with respect to the markers of the oxidative status. 16 normal subjects served as controls. Results: All patients showed evidence of increased oxidative stress which was more severe in HD than in PD patients and which was exacerbated by HD. When cardiac, cerebral, and vascular diseases were analyzed separately, plasma MDA-4HNE and TAS were significantly higher in more severely affected HD patients, but not in PD patients. In HD patients the CVD index was directly correlated with both MDA-4HNE and TAS (r = 0.42, p < 0.01; r = 0.39, p < 0.01) and inversely correlated with α-tocopherol (r = –0.32, p < 0.05). MDA-4HNE and TAS were directly correlated in HD patients and inversely correlated in control subjects. Conclusions: Our data show that, in spite of increased antioxidant defense, there is a relationship between the degree of lipid peroxidation and the severity of CVD in HD patients. Moreover, these data underscore the utility of MDA-4HNE, α-tocopherol, and TAS in the evaluation of cardiovascular disease.

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Section: Discussionsupporting

confidence: 81%

“…This may explain the lower intensity of oxidative stress described in peritoneal dialysis (PD) patients [20, 21, 22, 23]as compared with HD patients [24, 25, 26, 27, 28, 29, 30, 31, 32, 33]. …”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Cardiovascular Disease in Dialyzed Patients

Usberti

Gerardi

Gazzotti

et al. 2002

Nephron

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“…This abnormal pentose shunt has not been found in CAPD patients [21]. In CAPD patients, Taccone-Gallucci [21] found in creased erythrocytary tocopherol concentrations in rela tion to the control group. In our survey, there were no differences in erythrocytary tocopherol concentrations between CAPD patients and the control group, and the ratio between erythrocytary tocopherol and serum bioavailable tocopherol (RBC-E/vit E-STD) was similar for CAPD and control groups.…”

Section: Discussionmentioning

confidence: 84%

“…It could be explained by a metabolic block of the phosphate pentose shunt in RBC of HD patients as described by Yawata and Jacobs [22]. This abnormal pentose shunt has not been found in CAPD patients [21]. In CAPD patients, Taccone-Gallucci [21] found in creased erythrocytary tocopherol concentrations in rela tion to the control group.…”

Section: Discussionmentioning

confidence: 93%

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Serum and Erythrocyte Tocopherol in Uremic Patients: Effect of Hemodialysis versus Peritoneal Dialysis

et al. 1993

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α-Tocopherol is transferred from serum to erythrocytes by high-density lipoproteins (HDL). We have studied total serum, HDL and erythrocyte tocopherol concentration in uremic patients on hemodialysis (HD; n = 18) and continuous ambulatory peritoneal dialysis (CAPD; n = 14), and the relationship between HDL and erythrocyte tocopherol content. Serum and erythrocyte tocopherol were determined by high-performance liquid chromatography. Serum tocopherol levels were higher in CAPD patients (p < 0.05) than in control (n = 30) and HD groups. Erythrocyte tocopherol was lower in HD patients than in the controls but there were no differences between CAPD patients and the control group. Bioavailable tocopherol was found to be normal in both HD and CAPD patients. HDL-tocopherol was lower in both HD and CAPD groups, but probably enough to reach a normal level of tocopherol in erythrocytes, as has been demonstrated in CAPD patients. So, although a defect in the transfer of tocopherol to red blood cells is possible, some other causes could influence it too, as a greater antioxidant consumption in HD patients.

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Uremic Dysmetabolism and Its Effect on Immunocompetent and Erythroid Cell Function

Widerøe

1987

Advances in Experimental Medicine and Biology

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Red Blood Cell Membrane Lipid Peroxidation in Continuous Ambulatory Peritoneal Dialysis Patients

Cited by 28 publications

References 5 publications

Oxidative Stress and Cardiovascular Disease in Dialyzed Patients

Oxidative Stress and Cardiovascular Disease in Dialyzed Patients

Serum and Erythrocyte Tocopherol in Uremic Patients: Effect of Hemodialysis versus Peritoneal Dialysis

Uremic Dysmetabolism and Its Effect on Immunocompetent and Erythroid Cell Function

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