Red blood cell membrane mechanical fluctuations in non-proliferative and proliferate diabetic retinopathy

Abstract

This new rheological characteristic demonstrates differences in the mechanical properties of RBCs in different stages of diabetic retinopathy. The significant reduction in CMF in patients with PDR may shed more light on the possible mechanism modulating retinal ischemia and leading to angiogenesis in these patients. Larger-scale studies are needed to evaluate these findings and the possible correlation between significantly lower CMF values and the progression of diabetic retinopathy.

Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes

“…Ischemia is a critical component of DR, and it is potentially influenced by anemia, the main indicator of the blood oxygen delivery capacity [ 25 ]. Previous studies have suggested that, compared with normal red blood cells, the erythrocytes of diabetic patients have decreased deformability and increased aggregation at the capillary level [ 26 – 30 ]. This condition could make them more fragile and susceptible to breakage, which would lower the hemoglobin levels.…”

Structural alterations of the erythrocyte membrane proteins in diabetic retinopathy

“…Characteristically, Vekasi et al [43] found pathological plasma and whole blood viscosity with concomitant increased red blood cell aggregation in patients with diabetic retinopathy compared with controls. Moreover, Goldstein et al [17] have recently reported differences in the mechanical properties of red blood cells between nonproliferative and proliferative diabetic retinopathy. Our results support those findings by casting light on the pathogenic mechanisms linking erythrocyte membrane protein alterations to subsequent altered erythrocyte rheology and to the development of diabetic retinopathy.…”

Συσχέτιση Βαρύτητας Διαβητικής Αμφιβληστροειδοπάθειας Με Βιοχημικές Και Μορφολογικές Αλλοιώσεις Των Ερυθρών Αιμοσφαιρίων

“…Χαρακτηριστικά, οι Vekasi και συνεργάτες βρήκαν παθολογική γλοιότητα πλάσματος και ολικού αίματος με ταυτόχρονη αύξηση της συγκολλητικότητας των ερυθρών αιμοσφαιρίων σε ασθενείς με ΔΑ σε σύγκριση με ομάδα ελέγχου (Vekasi et al 2001). Επίσης, οι Goldstein και συνεργάτες πρόσφατα ανακοίνωσαν διαφορές στις μηχανικές ιδιότητες των ερυθρών αιμοσφαιρίων μεταξύ μη παραγωγικής και παραγωγικής ΔΑ (Goldstein et al 2004). Τα αποτελέσματά μας υποστηρίζουν αυτά τα ευρήματα ρίχνοντας φως στους παθογενετικούς μηχανισμούς που συνδέουν τις μεταβολές των πρωτεϊνών της ερυθροκυτταρικής μεμβράνης με τις επακόλουθες ρεολογικές μεταβολές των ερυθροκυττάρων και την ανάπτυξη ΔΑ.…”