Red cell antigen phenotypes in blood donors &amp; thalassaemia patients for creation of red cell antigen-matched inventory

Kulkarni, Shrikant; Choudhary, Bhavika; Gogri, Harita; Sharma, Jayashree; Madkaikar, Manisha

doi:10.4103/ijmr.ijmr_1199_18

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…The observed frequencies of the Duffy system antigens in our study were Fya antigen 73.8% and Fyb antigen 53.3%. Kulkarni et al in India also reported similar frequencies with Fya antigen higher than Fyb like our study [23].…”

Section: Discussionsupporting

confidence: 88%

Frequency of Extended Red Cell Antigen Phenotype Among Patients of Hematological Diseases: A Single Center Study

Tariq¹,

Ahmed²,

Ashfaq³

et al. 2022

Cureus

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BackgroundAlloimmunization of erythrocytes is a major problem in patients with hematological diseases that require frequent blood transfusions. Matching of extended red cell antigens of Kell, MNS, Kidd, and Duffy can decrease the risk of alloimmunization. Hence, in this study, the frequencies of the extended red cell phenotypes were explored. ObjectiveTo find out the frequency of extended red blood cell antigen phenotypes among patients with hematological diseases. MethodsThis cross-sectional research study was performed on 488 patients diagnosed with hematological diseases who required blood transfusion at the National Institute of Blood Disease and Bone Marrow Transplantation Karachi for a period of 1.42 years from November 2019 to March 2021. The blood of patients was analyzed for antigen phenotypes of different blood group systems including Kell, MNS, Kidd, and Duffy. The data obtained were interpreted. ResultsAmong the 488 patients, 284 (58.20%) patients were male, and 204 (41.80%) patients were female with a mean age of 8.1 years. Beta thalassemia was the most common hematological disease reported in 354 (72.5%) of the patients. The most common blood group was O positive reported in 182 (37.3%) of the patients followed by B positive blood group in 124 (25.4%). The frequencies of extended red cell antigen phenotypes in the patients were K antigen 14 (2.9%), Kp a antigen 26 (5.3%), Kp b antigen 424 (86.9%), Fy a antigen 360 (73.8%), Fy b antigen 260 (53.3%), Jk a antigen 294 (60.2%), Jk b antigen 326 (66.8%), M antigen 410 (84.0%) and N antigen 306 (62.7%). ConclusionBeta thalassemia was the most common hematological disease followed by iron deficiency anemia, aplastic anemia, and acute leukemia. Patients with hematological diseases had a higher prevalence of Kp b antigen followed by M, Fy a , Jk b , N, Jk a , Fy b , Kp a, and K antigen. O positive was the most frequent blood group followed by B positive, A positive and AB positive blood group.

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Section: Discussionsupporting

confidence: 88%

Frequency of Extended Red Cell Antigen Phenotype Among Patients of Hematological Diseases: A Single Center Study

Tariq¹,

Ahmed²,

Ashfaq³

et al. 2022

Cureus

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Prevalence of blood group antigens among regular blood donors: A single center study from South India with a review of national literature

Chenna

Polavarapu

Shastry

2023

Transfusion and Apheresis Science

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Extended red blood cell phenotyping among regular donors in Fayoum, Egypt. Red Blood Cell Inventory Plan

Abdelrazik,

Abdelaziz

2023

EGJH

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Background Antibodies to clinically significant red cell antigens contribute to hemolytic transfusion reactions and hemolytic disease of fetus and newborn. The aim of the study was to estimate the prevalence of extended red cell antigen phenotypes among regular donors in Fayoum, Egypt, and to create an emergency model database for chronic transfusion patients. Similar data in Egypt is rare to find in the literature. Patients and methods The study was carried out over 1 year from December 2020 until November 2021in Fayoum University Hospital Blood Bank. In all, 1834 healthy known blood donor samples were analyzed for major Rh phenotypes (D, C, c, E, e) and for other clinically significant systems including Kell, Kidd, MNS, and Duffy. Results Phenotypic frequencies of Rh system were D+ (84.4%), e+ (79.6%), and C+ (63.9%). The K antigen frequency was 4.3%, Jka 79.4%, Jkb 62.37%, Fy a 33.2%, Fy b 44.4%, M antigen 88%, N antigen 38.6%, and the S and s antigens 48.2 and 85.3%, respectively. Conclusion Determination of red cell antigen phenotyping in Fayoum, Egypt, plays an important role in setting a routine phenotyping strategy for multiple transfused patients by keeping the donor database for rare phenotypes to prevent hemolytic transfusion reaction.

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Red cell antigen phenotypes in blood donors & thalassaemia patients for creation of red cell antigen-matched inventory

Cited by 3 publications

References 21 publications

Frequency of Extended Red Cell Antigen Phenotype Among Patients of Hematological Diseases: A Single Center Study

Frequency of Extended Red Cell Antigen Phenotype Among Patients of Hematological Diseases: A Single Center Study

Prevalence of blood group antigens among regular blood donors: A single center study from South India with a review of national literature

Extended red blood cell phenotyping among regular donors in Fayoum, Egypt. Red Blood Cell Inventory Plan

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