Red/NIR emission carbonized polymer dots based on citric acid-benzoylurea and their application in lymph nodes imaging

Shan, Feishi; Zhang, Tingrui; Liao, Chengshuang; Yue, Xue; Zhang, Jing; Li, Y.; Liu, Yanman; Cao, Zhixing; Wang, Min; Zhang, Yahui; Wang, Leyong; Wang, Zhouyu; Yu, Xiao‐Qi

doi:10.1016/j.cclet.2023.108402

Cited by 8 publications

(4 citation statements)

References 43 publications

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“…128 In addition to easier modification methods and functionalization properties, CPDs have widespread application potential, especially for fluorescent sensing and in vivo imaging, drug or protein delivery, and disease diagnosis and treatment (Figure 3). 129…”

Section: Structural Properties Of Gqdsmentioning

confidence: 99%

“…Notably, the RCPDs can target lymph nodes for imaging and are potential lymph node-targeting imaging agents. 129 The CPDs synthesized by Yang et al from lignite primarily form carbon cores combined with polyvinylpyrrolidone, CA, and tryptophan, mainly producing short polymer chains and surface functional groups. Based on smart sensing systems, the real-time in situ quantification of Cu 2+ and S 2− can be visualized.…”

Section: Chemicalmentioning

confidence: 99%

“…Yu et al prepared NIR-emitting CPDs (RCPDs) with single- and two-photon bioimaging based on CA and benzoylurea. Notably, the RCPDs can target lymph nodes for imaging and are potential lymph node-targeting imaging agents …”

Section: Sensing and Imaging Applications Of Cds-based Sensorsmentioning

confidence: 99%

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Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Yang,

Xu,

et al. 2023

Chem. Rev.

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Advances in nanotechnology and nanomaterials have attracted considerable interest and play key roles in scientific innovations in diverse fields. In particular, increased attention has been focused on carbon-based nanomaterials exhibiting diverse extended structures and unique properties. Among these materials, zero-dimensional structures, including fullerenes, carbon nano-onions, carbon nanodiamonds, and carbon dots, possess excellent bioaffinities and superior fluorescence properties that make these structures suitable for application to environmental and biological sensing, imaging, and therapeutics. This review provides a systematic overview of the classification and structural properties, design principles and preparation methods, and optical properties and sensing applications of zero-dimensional carbon nanomaterials. Recent interesting breakthroughs in the sensitive and selective sensing and imaging of heavy metal pollutants, hazardous substances, and bioactive molecules as well as applications in information encryption, super-resolution and photoacoustic imaging, and phototherapy and nanomedicine delivery are the main focus of this review. Finally, future challenges and prospects of these materials are highlighted and envisaged. This review presents a comprehensive basis and directions for designing, developing, and applying fascinating fluorescent sensors fabricated based on zero-dimensional carbon nanomaterials for specific requirements in numerous research fields.

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Section: Structural Properties Of Gqdsmentioning

confidence: 99%

Section: Chemicalmentioning

confidence: 99%

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Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Yang,

Xu,

et al. 2023

Chem. Rev.

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“…In the field of CPDs, citric acid (CA) and urea have been widely acknowledged as classical preparation systems , while urea derivatives as precursors are rarely reported. The urea derivatives currently used are semicarbazide, hydroxyurea, and benzoylurea, , which provide a great possibility for the biological functionalization of CPDs. However, the study of disubstituted urea as a precursor has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Carbonized Polymer Dots with Aggregation-Induced Effect for Type I Photodynamic Therapy

Liao

Zhu

et al. 2023

ACS Appl. Nano Mater.

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Carbonized polymer dots (CPDs) have attracted great interest as a nanomaterial in biomedical applications, especially in imaging and photodynamic therapy (PDT). However, CPDs with an aggregation-induced effect for type I PDT has been rarely reported. In this work, N,N′-dimethylurea and citric acid were used as precursors to prepare CPDs (YCPDs) with aggregation-induced effect in one pot by the solvothermal method. The YCPDs have a yellow emission of 550 nm and a high quantum yield of 68%, which lays a solid foundation for cell imaging. In addition, YCPDs can produce • O 2 − under white light irradiation and obtain • OH through electron transfer or hydrogen atom abstraction. In vitro results show that YCPDs possess great cytocompatibility but exert severe cytotoxicity to HeLa cells with only 2% of cell viability when exposed to ultralow-power-intensity (2.5 mW/cm 2 ) light irradiation. Therefore, YCPDs, as a promising type I PDT nanomaterial, have a great potential for cancer therapy.

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Advance of Near‐Infrared Emissive Carbon Dots in Diagnosis and Therapy: Synthesis, Luminescence, and Application

Hu,

Zheng,

Yang

et al. 2024

Adv Healthcare Materials

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Carbon dots (CDs) with good optical properties, biocompatibility, easy functionalization, and small size have attracted more and more attention and laid a good foundation for their applications in the biomedicine field. CDs emitted in near‐infrared regions (NIR‐CDs) can achieve high penetration depth imaging and produce high cytotoxic substance for disease treatment. Therefore, NIR‐CDs are promising materials to realize high‐quality imaging‐guided diagnostic and therapeutic integration. This review first introduces the current mainstream synthesis methods of NIR‐CDs by “top–down” and “bottom–up”. Second, the luminescence modes of NIR‐CDs are introduced, and the luminescence mechanisms based on carbon core state, surface state, molecular state, and crosslinking enhanced emission are summarized. Third, the applications and principles of NIR‐CDs in imaging, drug delivery, and non‐invasive therapeutics are introduced from a view of diagnosis and therapy. Finally, their prospects and challenges in biomedical and biotechnological applications are outlined.

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Red/NIR emission carbonized polymer dots based on citric acid-benzoylurea and their application in lymph nodes imaging

Cited by 8 publications

References 43 publications

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Carbonized Polymer Dots with Aggregation-Induced Effect for Type I Photodynamic Therapy

Advance of Near‐Infrared Emissive Carbon Dots in Diagnosis and Therapy: Synthesis, Luminescence, and Application

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