Red Propolis: Phenolics, Polyphenolics, and Applications to Microbiological Health and Disease

Freires, Irlan Almeida; Pingueiro, João Marcos Spessoto; Miranda, Stela Lima Farias de; Bueno‐Silva, Bruno

doi:10.1016/b978-0-12-813008-7.00024-2

Cited by 4 publications

(3 citation statements)

References 54 publications

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“…Among the promising natural products, Brazilian propolis is an important source of a variety of bioactive components with reported biological and pharmacological actions, such as anti-inflammatory, anesthetic, antioxidant, and immunomodulator, among others, attributed to a composition rich in caffeic, p-coumaric, and cinnamic acids [ 36 , 37 , 38 , 39 ]. The chemical properties of propolis can vary from one sample to another as its constitution derives from species of bees and the availability of plant sources [ 40 , 41 ]. It is composed of resinous and balsamic substances (50%–60%), waxes (30%–40%), essential oils (5%–10%), and pollen grains (5%) associated with microelements (calcium, strontium, iron, copper, aluminum, manganese, and vitamins B1, B2, B6, C, and E).…”

Section: Introductionmentioning

confidence: 99%

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

et al. 2020

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Patients with Parkinson’s disease (PD) manifest nonmotor and motor symptoms. Autonomic cardiovascular dysregulation is a common nonmotor manifestation associated with increased morbimortality. Conventional clinical treatment alleviates motor signs but does not change disease progression and fails in handling nonmotor features. Nutrition is a key modifiable determinant of chronic disease. This study aimed to assess the effects of propolis on cardiological features, heart rate (HR) and heart rate variability (HRV) and on nigrostriatal dopaminergic damage, detected by tyrosine hydroxylase (TH) immunoreactivity, in the 6-hydroxydopamine (6-OHDA) rat model of PD. Male Wistar rats were injected bilaterally with 6-OHDA or saline into the striatum and were treated with propolis or water for 40 days. Autonomic function was assessed by time domain parameters (standard deviation of all normal-to-normal intervals (SDNN) and square root of the mean of the squared differences between adjacent normal RR intervals (RMSSD)) of HRV calculated from electrocardiogram recordings. Reductions in HR (p = 1.47 × 10−19), SDNN (p = 3.42 × 10−10) and RMSSD (p = 8.2 × 10−6) detected in parkinsonian rats were reverted by propolis. Propolis attenuated neuronal loss in the substantia nigra (p = 5.66 × 10−15) and reduced striatal fiber degeneration (p = 7.4 × 10−5) in 6-OHDA-injured rats, which also showed significant weight gain (p = 1.07 × 10−5) in comparison to 6-OHDA-lesioned counterparts. Propolis confers cardioprotection and neuroprotection in the 6-OHDA rat model of PD.

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Section: Introductionmentioning

confidence: 99%

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

et al. 2020

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“…Along the wadis claws, look for Betoum (Pistacia atiantica), a protected Spezia, and Rhus tripartitum (Enneffatia et al, 2011). However, the evaluation of the antibacterial characteristics of propolis has been limited to a small number of investigations, primarily targeting the reference strains of the American Type Culture Collection (ATCC) (Freires et al, 2018;Gharbi et al, 2021). To the very best of the present knowledge, there is a lack of documentation regarding the antibacterial efficacy of Tiout ain sefra propolis from Algeria against the reference strains of microorganisms (CECT) belonging to the Spanish type culture collection.…”

Section: Introduction Introduction Introduction Introductionmentioning

confidence: 99%

An integrated investigation into the antibacterial and antioxidant properties of propolis against Escherichia coli cect 515: A dual in vitro and in silico analysis

BOUDOU,

GUENDOUZI,

BELKREDAR

et al. 2024

Not Sci Biol

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Urinary tract infections resulting from Escherichia coli, are prevalent and have become increasingly difficult to treat due to antibiotic resistance. This study aimed to explore the potential of propolis extract from beehives in Algeria’s Tiout region as a natural antibacterial agent against E. coli CECT_515. The phytochemical composition, antioxidant activity, and antibacterial action of the extract has been evaluated and compared to four synthetic antibiotics, both in vitro and in silico. The propolis extract had high levels of total polyphenol and total flavonoids, regarding its antioxidant properties, the extract showed an important ability of DPPH radicals scavenging, as determined by its IC50 value of 330.08±13.35 μg/mL. The excerpt showed important antibacterial efficacy against Escherichia coli, as demonstrated with important inhibition zones. The extract’s inhibitory effects were compared to four synthetic antibiotics, including gentamicin, pipemidic acid, cefazolin, and colistin, molecular docking analysis revealed that the propolis extract interacted with the active site of beta-lactamase, a protein responsible for antibiotic resistance, and showed binding affinities and conformational stability during molecular dynamics simulation for 250 ns. Overall, the results suggest that the propolis has significant antioxidant and antibacterial properties and could serve as a promising natural alternative to synthetic antibiotics for the treatment of E. coli infections.

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“…a partir de exsudatos coletados em diversas espécies vegetais, tendo como principal fonte resinífera Dalbergia ecastaphyllum L., que é utilizada na proteção da colmeia contra insetos, fungos e bactérias, e como termorregulador. No Brasil, a própolis vermelha foi catalogada como o 13º tipo de própolis, se diferenciando dos demais tipos de própolis pela intensidade da coloração vermelha, composição química rica em isoflavonóides e alta atividade biológica (FREIRES et al, 2018).…”

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Moureira¹,

Santos²,

Carvalho³

et al. 2020

Ciências Agrárias: Conhecimentos Científicos E Técnicos E Difusão De Tecnologias

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Direitos para esta edição cedidos à Atena Editora pelos autores.

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Red Propolis: Phenolics, Polyphenolics, and Applications to Microbiological Health and Disease

Cited by 4 publications

References 54 publications

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

An integrated investigation into the antibacterial and antioxidant properties of propolis against Escherichia coli cect 515: A dual in vitro and in silico analysis

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