Red Star Ruby (Sunrise) and blond qualities of Jaffa grapefruits and their influence on plasma lipid levels and plasma antioxidant activity in rats fed with cholesterol-containing and cholesterol-free diets

Gorinstein, Shela; Leontowicz, Hanna; Leontowicz, Maria; Drzewiecki, Jerzy; Jastrzębski, Zenon; Tapia, María Soledad; Katrich, Elena; Trakhtenberg, Simon

doi:10.1016/j.lfs.2004.12.049

Cited by 34 publications

(20 citation statements)

References 29 publications

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“…Other studies in rats or rabbits have shown some cholesterol-lowering effects of grapefruit polyphenols and black tea associated with increased bile acid excretion [41][42][43]. Apple polyphenols were also found to enhance in rats the cholesterol-7a-hydroxylase activity in the liver and to increase the excretion of faecal bile acids [44].…”

Section: Fxr Activation and Bile Acid Excretionmentioning

confidence: 93%

Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice

et al. 2010

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Section: Fxr Activation and Bile Acid Excretionmentioning

confidence: 93%

Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice

et al. 2010

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“…Pectin lowers blood and liver cholesterol in various animals, including guinea pigs (Gorinstein et al, 2005), rats (Krzysik et al, 2011), hamsters (Terpstra et al, 2002), chickens (Craig et al, 2006) and rabbits (Ismail et al, 1999). Based on results from several animal studies (Yamaguchi et al, 1995;Trautwein et al, 1998;Dongowski and Lorenz, 2004), it has been stated that the molecular composition of pectin affected cholesterol reductions in blood and liver.…”

Section: Pectin Lowers Cholesterol In Animal Modelsmentioning

confidence: 99%

Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women

et al. 2011

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Background/Objectives: Viscous fibers typically reduce total cholesterol (TC) by 3-7% in humans. The cholesterol-lowering properties of the viscous fiber pectin may depend on its physico-chemical properties (viscosity, molecular weight (MW) and degree of esterification (DE)), but these are not typically described in publications, nor required by European Food Safety Authority (EFSA) with respect to its generic pectin cholesterol-lowering claim. Subjects/Methods: Here, different sources and types of well-characterized pectin were evaluated in humans. Cross-over studies were completed in mildly hyper-cholesterolemic persons receiving either 15 g/day pectin or cellulose with food for 4 weeks. Results: Relative low-density lipoprotein (LDL) cholesterol (LDL-C) lowering was as follows: citrus pectin DE-70 ¼ apple pectin DE-70 (7-10% reduction versus control)4apple pectin DE-35 ¼ citrus pectin DE-354OPF (orange pulp fiber) DE-70 and low-MW pectin DE-704citrus DE-0. In a subsequent 3-week trial with 6 g/day pectin, citrus DE-70 and high MW pectin DE-70 reduced LDL-C 6-7% versus control (without changes in TC). In both studies, high DE and high MW were important for cholesterol lowering. Source may also be important as citrus and apple DE-70 pectin were more effective than OPF DE-70 pectin. Pectin did not affect inflammatory markers high-sensitivity C-reactive protein (hsCRP) nor plasma homocysteine. Conclusions: Pectin source and type (DE and MW) affect cholesterol lowering. The EFSA pectin cholesterol-lowering claim should require a minimum level of characterization, including DE and MW.

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“…Studies by Gorinstein et al [8] have previously suggested that diets supplemented with grapefruit improve plasma lipid levels and increase plasma antioxidant activity in experimental animals. Similar studies conducted on human subjects have shown that red grapefruit significantly lowers serum total cholesterol, low-density lipoprotein cholesterol and triglycerides in patients with coronary atherosclerosis [9].…”

Section: Introductionmentioning

confidence: 99%

Grapefruit juice improves glucose intolerance in streptozotocin-induced diabetes by suppressing hepatic gluconeogenesis

et al. 2015

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Red Star Ruby (Sunrise) and blond qualities of Jaffa grapefruits and their influence on plasma lipid levels and plasma antioxidant activity in rats fed with cholesterol-containing and cholesterol-free diets

Cited by 34 publications

References 29 publications

Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice

Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice

Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women

Grapefruit juice improves glucose intolerance in streptozotocin-induced diabetes by suppressing hepatic gluconeogenesis

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