Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats

Dolara, Piero; Luceri, Cristina; Filippo, Carlotta De; Femia, Angelo Pietro; Giovannelli, Lisa; Caderni, Giovanna; Cecchini, Cinzia; Silvi, Stefania; Orpianesi, Carla; Cresci, Alberto

doi:10.1016/j.mrfmmm.2005.04.022

Cited by 309 publications

(230 citation statements)

References 21 publications

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“…and higher levels of Lactobacillus spp. (Dolara et al, 2005). These studies applied both conventional culturing as well as molecular methods such as fluorescence in situ hybridization and denaturing gradient gel electrophoresis, which essentially target either well-known groups or provide comparative profiles rather than direct microbial identification.…”

Section: Modulation Of Gut Microbiota By Polyphenolsmentioning

confidence: 99%

Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities

et al. 2010

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Polyphenols, ubiquitously present in the food we consume, may modify the gut microbial composition and/or activity, and moreover, may be converted by the colonic microbiota to bioactive compounds that influence host health. The polyphenol content of fruit and vegetables and derived products is implicated in some of the health benefits bestowed on eating fruit and vegetables. Elucidating the mechanisms behind polyphenol metabolism is an important step in understanding their health effects. Yet, this is no trivial assignment due to the diversity encountered in both polyphenols and the gut microbial composition, which is further confounded by the interactions with the host. Only a limited number of studies have investigated the impact of dietary polyphenols on the complex human gut microbiota and these were mainly focused on single polyphenol molecules and selected bacterial populations. Our knowledge of gut microbial genes and pathways for polyphenol bioconversion and interactions is poor. Application of specific in vitro or in vivo models mimicking the human gut environment is required to analyse these diverse interactions. A particular benefit can now be gained from next-generation analytical tools such as metagenomics and metatranscriptomics allowing a wider, more holistic approach to the analysis of polyphenol metabolism. Understanding the polyphenol–gut microbiota interactions and gut microbial bioconversion capacity will facilitate studies on bioavailability of polyphenols in the host, provide more insight into the health effects of polyphenols and potentially open avenues for modulation of polyphenol bioactivity for host health.

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Section: Modulation Of Gut Microbiota By Polyphenolsmentioning

confidence: 99%

Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities

et al. 2010

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“…Furthermore, the intake of polyphenols and their derived products have significant effects on gut microbiota composition and probably their functional effects in mammalian tissues. Dolara et al (11) found that treatment with red wine polyphenols lowered the levels of Clostridium spp. and increased the levels of Lactobacillus spp.…”

mentioning

confidence: 99%

Effect of Dietary Supplementation of (^|^minus;)-Epigallocatechin Gallate on Gut Microbiota and Biomarkers of Colonic Fermentation in Rats

Unno

Sakuma

Mitsuhashi

2014

J Nutr Sci Vitaminol

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Summary Alterations in gut microbiota composition offer insights that may be relevant for several chronic conditions, including obesity. This study aimed to evaluate the effect of (2)-epigallocatechin gallate (EGCG) on the modulation of gut microbiota and biomarkers of colonic fermentation end-products in rats. Rats were fed an assigned diet of either a control diet, a 0.3% (w/w) EGCG diet, or a 0.6% (w/w) EGCG diet for 4 wk. Compared to the control group, the addition of 0.6% EGCG to the diet brought about a significant increase in the starch and protein contents in the feces collected in the fourth week of feeding, but the relative weights of abdominal adipose tissues of rats were inversely suppressed. Hostspecific bacterial community composition, as determined by terminal restriction fragment length polymorphism (T-RFLP) patterns for fecal 16S ribosomal RNA, showed a significant response in the reduced occupation of Clostridium spp. and an increased trend of Bacteroides by dietary supplementation with EGCG. The 0.6% EGCG diet also influenced the status of Bifidobacterium and Prevotella to a lesser extent. Interestingly, the cecum of rats fed the 0.6% EGCG diet contained lower levels of acetic and butyric acids, whereas EGCG had little influence on the cecal level of propionic acid. EGCG also reduced the cecal p-cresol concentration in a dose-dependent fashion. In conclusion, dietary EGCG affects the growth of certain species of gut microbiota in rats and is associated with the cecal pattern of short chain fatty acids which could be responsible for regulating energy metabolism in the body.

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“…The result obtained for alkaloids is higher than those reported for V. amygdalina and O. gratissimum by Udochukwu et al (2015). Tannins are polyphenolic compounds that have astringent, diuretic, anti-inflammatory, antiseptic, antioxidant and haemostatic properties (Dolara et al, 2005;Saxena et al, 2013). They are also used for treatment of gastric and duodenal tumors (Dolara et al, 2005;Saxena et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Tannins are polyphenolic compounds that have astringent, diuretic, anti-inflammatory, antiseptic, antioxidant and haemostatic properties (Dolara et al, 2005;Saxena et al, 2013). They are also used for treatment of gastric and duodenal tumors (Dolara et al, 2005;Saxena et al, 2013). The values of tannins of H. verticillata leaves was lower than that reported for V. amygdalina but higher than that reported for O. gratissimum by Udochukwu et al (2015).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical evaluation and GC-MS analysis of <i>Hyptis verticillata</i> cultivated in Calabar Cross River State, Nigeria

Egbung¹,

Anosike²,

Utu-Baku³

et al. 2018

Int. J. Bio. Chem. Sci

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Hyptis verticillata is a medicinal plant reported to possess strong antioxidant activity growing in the American continent with no evidence of its cultivation in Nigeria. The present study was designed to investigate the phytocompounds present in n-hexane extract of the leaves of H. verticillata cultivated in Calabar, Cross River State, Nigeria. The phytochemicals found in relatively high amounts were flavonoids (19.67±1.53%), phenols (13.20±0.40 mg/g) and saponins (7.17±1.04%). Others including phytates (0.42±0.76 mg/g), cyanogenic glycosides (3.80±0.20%) and oxalates (2.01±0.09%) were present in low concentrations. The GC-MS (gas chromatography-mass spectrometry) analysis of the extract revealed fifteen bio-active compounds, mainly hydrocarbons, fatty acid esters and alcohols. The most predominant compounds were, 9,12,15-octadecatrienoic acid, 2,3-bis(acetyloxy) propyl ester (18.17%), 5-cholestene-3-ol, 24-methyl-(17.48%), 1-iodo-2-methylnonane (10.89%), glycerol 1,2-dipalmitate (8.19%), 1-pentadecene (5.18%), 1-hexadecene (4.80%) and methyl-14-methylpentadecanoate (4.76%). The chemical profile of H. verticillata grown in Nigeria is akin to that in the West, hence may serve for similar aromatic and medicinal purposes.

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Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats

Cited by 309 publications

References 21 publications

Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities

Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities

Effect of Dietary Supplementation of (^|^minus;)-Epigallocatechin Gallate on Gut Microbiota and Biomarkers of Colonic Fermentation in Rats

Phytochemical evaluation and GC-MS analysis of <i>Hyptis verticillata</i> cultivated in Calabar Cross River State, Nigeria

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