Reddish Nodule on the Hand: A Quiz

Panés-Rodríguez, A.; Vildósola-Esturo, S.; Rodríguez-Pérez, Irene; Tuneu-Valls, A.; Alcázar-Viladomiu, E. del

doi:10.2340/00015555-2396

Cited by 1 publication

(3 citation statements)

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“…1 In culture, M. marinum , M. kansasii , and M. aviumintracellulare are slow-growing mycobacteria (3-4weeks), while M. fortuitum , M. chelonaea , and M. abscessus are rapidly growing mycobacteria. 1 , 2 , 11 Since the concentration of organisms may be low, multiple cultures are recommended. Recent studies evidenced that the broad range panmycobacterial PCR can detect all the mycobacterial species directly from clinical specimens with an excellent specificity.…”

Section: Discussionmentioning

confidence: 99%

“…Mycobacterial DNA identification using PCR is considered not only the most sensitive and specific test to confirm the diagnosis but also the most rapid laboratory test, with a median time to identification of 6 days versus 35 days for culture and which represents a 29-day shorter time to results. 11 , 12 Skin manifestation during M. kansasii infection are possible and clinical features may vary from nodules, verrucous or ulcerated erythematous plaques, sometimes distributed as sporotrichoid-like lesions, ulcers, cellulitis, abscesses, seromas and even papulo-necrotic tuberculoid-like reactions. 13 Being immunosuppressed subjects more susceptible, a primary cutaneous infection in immunocompetent individual is rare.…”

Section: Discussionmentioning

confidence: 99%

“…abscessus are rapidly growing mycobacteria. 1,2,11 Since the concentration of organisms may be low, multiple cultures are recommended. Recent studies evidenced that the broad range pan-mycobacterial PCR can detect all the mycobacterial species directly from clinical specimens with an excellent specificity.…”

Section: Accepted Papermentioning

confidence: 99%

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Mycobacterium Kansasii infection in a psoriasis patient treated with adalimumab and switch to apremilast: first report and literature review

Brunasso

Javor

Pontali³

et al. 2021

Dermatol Reports

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Patient under anti-TNF-alpha treatment have an increased risk of mycobacterial infections, particularly tuberculosis. Only four case reports of Mycobacterium kansasii infection under anti-TNF-α treatment (two with etanercept, two with infliximab) have been reported, but none under adalimumab. A 72-year-old man treated with adalimumab for psoriasis vulgaris and arthropathic psoriasis, complained on nocturnal cough, occasional hemoptysis and the new onset of ill-defined, reddish, asymptomatic persistent plaquesnodules covered by serum crusts on his back, on the dorsum of the right hand and right middle finger. Routine laboratory investigations, HIV and TB screening (QuantiFERONTB- Gold test) were all within normal limits. A skin biopsy was inconclusive and special stainings resulted negative for microorganisms. Only PCR identified M. kansasii. The patient stopped adalimumab and started anti-TB treatment with gradual improvement of the skin lesions. At 26 months follow-up visit no signs or symptoms of relapse of M. kansasii disease occurred.

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Section: Discussionmentioning

confidence: 99%