PurposeThe safety-related features of destinations affect tourist experiences and consequently influence destination choices. This research investigates the role of spatial profile and safety in the destination choices of digital nomads.Design/methodology/approachThe study was designed using the multi-research method. To determine the spatial patterns of digital nomads' destination choices, Getis-Ord’s Gi is utilized, and spatial regression techniques are employed to ascertain the role of safety in these choices.FindingsThe main result of the research is that the most visited cities are spatially clustered in Asia, Europe and America. In this regard, digital nomads' destination choices exhibit similarities to those of traditional tourists. However, safety plays a significant role in destination preferences.Originality/valueThe research findings provide valuable insight into the relationship between digital nomads' travel preferences and safety, thereby serving as a significant source of information for destination marketing and management.