Redirecting Normal and Cancer Stem Cells to a Mammary Epithelial Cell Fate

Frank-Kamenetskii, Anastasia; Booth, Brian W.

doi:10.1007/s10911-019-09439-x

Cited by 7 publications

(11 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These naturally occurring signals direct cell differentiation and potentially prevent tumor progression by producing anti-proliferative and apoptotic signals for abnormal cells. Irregularities in production of needed stimuli or pathways that control cell proliferation will lead to uncontrolled apoptosis, tumor formations, and cancer [2]. Several studies have demonstrated that abnormal cellular transformation could be repressed as long as cancer cells were restricted to a tumor-hostile location within the tissue, and that the normal microenvironment can suppress cancer formation by cellular signaling from the surrounding cells and matrix [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Induction of phenotypic changes in HER2-postive breast cancer cells in vivo and in vitro

et al. 2020

Self Cite

View full text Add to dashboard Cite

The influence of breast cancer cells on normal cells of the microenvironment, such as fibroblasts and macrophages, has been heavily studied but the influence of normal epithelial cells on breast cancer cells has not. Here using in vivo and in vitro models we demonstrate the impact epithelial cells and the mammary microenvironment can exert on breast cancer cells. Under specific conditions, signals that originate in epithelial cells can induce phenotypic and genotypic changes in cancer cells. We have termed this phenomenon "cancer cell redirection." Once breast cancer cells are redirected, either in vivo or in vitro, they lose their tumor forming capacity and undergo a genetic expression profile shift away from one that supports a cancer profile towards one that supports a non-tumorigenic epithelial profile. These findings indicate that epithelial cells and the normal microenvironment influence breast cancer cells and that under certain circumstances restrict proliferation of tumorigenic cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Induction of phenotypic changes in HER2-postive breast cancer cells in vivo and in vitro

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…This normalization phenomenon has been documented in neuroblastomas in which the Schwann cells of the stroma are thought to induce the maturation of proliferating neuroblasts into mature, nonproliferating ganglion cells [115]. Moreover, conclusions drawn from the original experiments by Mintz and Illmensee in the 1970s and others since then buttress the notion that normalization is experimentally reproducible [94,116,117] and that it also occurs in clinical settings.…”

Section: Corollaries and Predictionsmentioning

confidence: 87%

Over a century of cancer research: Inconvenient truths and promising leads

Sonnenschein

Soto

2020

PLoS Biol

View full text Add to dashboard Cite

Despite over a century of intensive efforts, the great gains promised by the War on Cancer nearly 50 years ago have not materialized. Since 1999, we have analyzed the lack of progress in explaining and "curing" cancer by examining the merits of the premises that determine how cancer is understood and treated. Our ongoing critical analyses have aimed at clarifying the sources of misunderstandings at the root of the cancer puzzle while providing a plausible and comprehensive biomedical perspective as well as a new theory of carcinogenesis that is compatible with evolutionary theory. In this essay, we explain how this new theory, the tissue organization field theory (TOFT), can help chart a path to progress for cancer researchers by explaining features of cancer that remain unexplainable from the perspective of the still hegemonic somatic mutation theory (SMT) and its variants. Of equal significance, the premises underlying the TOFT offer new perspectives on basic biological phenomena.

show abstract

“…Accelerated cell turnover occurs during pregnancy, lactation, and involution with rapid differentiation, replication, and apoptosis [11,12]. Constant remodeling of the mammary gland is found throughout one's lifetime, indicating active stem cells [11][12][13][14]. The mammary gland is often studied for stem cells, microenvironments, and development since the majority of growth and differentiation occurs postnatal and also due to the regular cellular remodeling that occurs during monthly menstrual cycles [12,14].…”

Section: Mammary Gland Developmentmentioning

confidence: 99%

“…A stem cell niche comprises the microenvironment that encircles stem cells and the immediate cellular activity through short and long distances [14,15]. The mammary microenvironment contains several important aspects, including stem cells, neighboring signaling cells, supporting stroma, extracellular matrix (ECM), and intercellular signals that regulate stem and signaling cells [5,6].…”

Section: Mammary Gland Stem Cell Nichementioning

confidence: 99%

“…The mammary microenvironment contains several important aspects, including stem cells, neighboring signaling cells, supporting stroma, extracellular matrix (ECM), and intercellular signals that regulate stem and signaling cells [5,6]. Various cell types comprise the normal mammary niche, including epithelial cells, myoepithelial cells, adipocytes, nerve cells, endothelial cells, and fibroblasts [14][15][16]. Immune cells, such as macrophages, are common as well [14].…”

Section: Mammary Gland Stem Cell Nichementioning

confidence: 99%

See 1 more Smart Citation

The Influence of the Normal Mammary Microenvironment on Breast Cancer Cells

Campbell

Booth

2023

Cancers

Self Cite

View full text Add to dashboard Cite

The tumor microenvironment is recognized as performing a critical role in tumor initiation, progression, and metastasis of many cancers, including breast cancer. The breast cancer microenvironment is a complex mixture of cells consisting of tumor cells, immune cells, fibroblasts, and vascular cells, as well as noncellular components, such as extracellular matrix and soluble products. The interactions between the tumor cells and the tumor microenvironment modulate tumor behavior and affect the responses of cancer patients to therapies. The interactions between tumor cells and the surrounding environment can include direct cell-to-cell contact or through intercellular signals over short and long distances. The intricate functions of the tumor microenvironment in breast cancer have led to increased research into the tumor microenvironment as a possible therapeutic target of breast cancer. Though expanded research has shown the clear importance of the tumor microenvironment, there is little focus on how normal mammary epithelial cells can affect breast cancer cells. Previous studies have shown the normal breast microenvironment can manipulate non-mammary stem cells and tumor-derived cancer stem cells to participate in normal mammary gland development. The tumorigenic cells lose their tumor-forming capacity and are “redirected” to divide into “normal”, non-tumorigenic cells. This cellular behavior is “cancer cell redirection”. This review will summarize the current literature on cancer cell redirection and the normal mammary microenvironment’s influence on breast cancer cells.

show abstract

Redirecting Normal and Cancer Stem Cells to a Mammary Epithelial Cell Fate

Cited by 7 publications

References 44 publications

Induction of phenotypic changes in HER2-postive breast cancer cells in vivo and in vitro

Induction of phenotypic changes in HER2-postive breast cancer cells in vivo and in vitro

Over a century of cancer research: Inconvenient truths and promising leads

The Influence of the Normal Mammary Microenvironment on Breast Cancer Cells

Contact Info

Product

Resources

About