Redox Responsive Copolyoxalate Smart Polymers for Inflammation and Other Aging-Associated Diseases

Vetha, Berwin Singh Swami; Adam, Angela Guma; Aileru, Azeez A.

doi:10.3390/ijms22115607

Cited by 7 publications

(3 citation statements)

References 57 publications

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“…6 ). 33 , 40 , 41 Although it is expected that NOX-4 increase is related to increased H 2 O 2 production, the low NOX-4 observed in (mRen2)27 could possibly result in singlet oxygen (O 2 − ) generation. Superoxide dismutase converts O 2 − to H 2 O 2 resulting in increased intracellular ROS buildup.…”

Section: Discussionmentioning

confidence: 99%

Functional Significance of Angiotensin Receptor Type 2 in the Neuroplasticity of Autonomic Ganglia in (mRen2)27 Transgenic Hypertensive Rats

Vetha

Byrum

Peele

et al. 2022

Journal of Cardiovascular Pharmacology

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Section: Discussionmentioning

confidence: 99%

Functional Significance of Angiotensin Receptor Type 2 in the Neuroplasticity of Autonomic Ganglia in (mRen2)27 Transgenic Hypertensive Rats

Vetha

Byrum

Peele

et al. 2022

Journal of Cardiovascular Pharmacology

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“…Recently, ROS-responsive biomaterials have been identified as a type of promising therapeutic substance to alleviate oxidative stress in tissue microenvironments, and for use as a vehicle triggered by inflammatory diseases to realize drug release under physiological oxidative microenvironments. The various applications of ROSresponsive biomaterials in tissue regeneration and disease therapy, such as cardiovascular diseases, osteoarthritis, chronic diabetic wounds, inflammatory bowel disease and other inflammatory diseases, are summarized (Swami Vetha et al, 2021). Frontiers in Bioengineering and Biotechnology frontiersin.org…”

Section: Reactive Oxygen Speciesmentioning

confidence: 99%

The potential of oxygen and nitrogen species-regulating drug delivery systems in medicine

Sołtan¹,

Bartusik‐Aebisher

Aebisher

2022

Front. Bioeng. Biotechnol.

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The focus of this review is to present most significant advances in biomaterials used for control of reactive oxygen/nitrogen species (ROS/RNS, RONS) in medicine. A summary of the main pathways of ROS production and the main pathways of RNS production are shown herein. Although the physiological and pathological roles of RONS have been known for at least 2decades, the potential of their control in management of disease went unappreciated. Recently, advances in the field of biochemical engineering and materials science have allowed for development of RONS-responsive biomaterials for biomedical applications, which aim to control and change levels of reactive species in tissue microenvironments. These materials utilize polymers, inorganic nanoparticles (NPs), or organic-inorganic hybrids. Thus, biomaterials like hydrogels have been developed to promote tissue regeneration by actively scavenging and reducing RONS levels. Their promising utility comes from thermo- and RONS-sensitivity, stability as a delivery-medium, ease for incorporation into other materials and facility for injection. Their particular attractiveness is attributed to drug release realized in targeted tissues and cells with elevated RONS levels, which leads to enhanced treatment outcomes and reduced adverse effects. The mechanism of their action depends on the functional groups employed and their response to oxidation, and may be based on solubility changes or cleavage of chemical bonds. When talking about antioxidants, one should also mention oxidative stress, which we call the imbalance between antioxidants and reactive oxygen species, which occurs due to a deficiency of endogenous antioxidants and a low supply of exogenous antioxidants. This study is a review of articles in English from the databases PubMed and Web of Science retrieved by applying the search terms “Oxygen Species, Nitrogen Species and biomaterials” from 1996 to 2021.

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“…7 As a result, we believe PVO nanoparticles have a lot of potential as new antioxidants and medication delivery methods for ROS-related inflammatory disorders. 8…”

Section: Vanillin Oxalate Nanoparticle [Anti-oxidant]mentioning

confidence: 99%

A Review on Nanoparticles Drug Delivery System

Pawar¹,

Kachave²,

Kanawade³

et al. 2021

J. Drug Delivery Ther.

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The method or process of delivering a pharmaceutical ingredient to create a therapeutic effect in people or animals is referred to as drug delivery. Nasal and pulmonary routes of medication administration are becoming increasingly important in the treatment of human illnesses. These methods, especially for peptide and protein therapies, provide potential alternatives to parenteral drug administration. Several medication delivery methods have been developed for this purpose and are being tested for nasal and pulmonary delivery. Chitosan, Alginate, vanilline oxalate, zinc oxalate, cellulose, polymeric micelles, Gliadin, and phospholipid are examples of these. Multidrug resistance, a key issue in chemotherapy, can be reversed with these nanoparticles. Surgery, chemotherapy, immunotherapy, and radiation are all well-established treatments used in cancer treatment. A nanoparticle has emerged as a potential method for the targeted delivery of medicines used to treat certain illnesses. Keywords: Nasal Drug Delivery, Pulmonary Drug Delivery, Nanoparticles

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Redox Responsive Copolyoxalate Smart Polymers for Inflammation and Other Aging-Associated Diseases

Cited by 7 publications

References 57 publications

Functional Significance of Angiotensin Receptor Type 2 in the Neuroplasticity of Autonomic Ganglia in (mRen2)27 Transgenic Hypertensive Rats

Functional Significance of Angiotensin Receptor Type 2 in the Neuroplasticity of Autonomic Ganglia in (mRen2)27 Transgenic Hypertensive Rats

The potential of oxygen and nitrogen species-regulating drug delivery systems in medicine

A Review on Nanoparticles Drug Delivery System

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