Redox-responsive micelles self-assembled from multi-block copolymer for co-delivery of siRNA and hydrophobic anticancer drug

Liu, Benxing; Tan, Lianjiang; He, Changyu; Liu, Bingya; Zhu, Zhenggang; Gong, Bing; Shen, Yu‐Mei

doi:10.1007/s00289-018-2600-y

Cited by 6 publications

(3 citation statements)

References 47 publications

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“…Polymersomes with the diameter of less than 200 nm can escape from the reticuloendothelial system of hepatic sinusoid and spleen. 33 It was shown from the zeta potential results that there was a negative charge on the surface of the polymersomes, which could improve the blood compatibility and prolong the circulation time of polymersomes because of their reduced interactions with blood constituents. 34 The polydispersity index (PDI) was used to evaluate the uniformity of size distribution of polymersomes, and a low PDI value indicated the distribution of polymersomes with a narrow size range.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…After DOX was encapsulated in polymersomes, the mean diameter of DOX-loaded polymersomes increased to 75–95 nm. Polymersomes with the diameter of less than 200 nm can escape from the reticuloendothelial system of hepatic sinusoid and spleen . It was shown from the zeta potential results that there was a negative charge on the surface of the polymersomes, which could improve the blood compatibility and prolong the circulation time of polymersomes because of their reduced interactions with blood constituents .…”

Section: Resultsmentioning

confidence: 99%

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Inhibiting Multidrug Resistance with Transferrin-Targeted Polymersomes through Optimization of Ligand Density

Yi,

Li,

Gong

et al. 2023

Langmuir

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Transferrin-conjugated polymersomes, transferrin–biotin/avidin/biotin–Pluronic F127–poly(lactic acid) (Tf-F127-PLA), were successfully prepared through a biotin–avidin bridging technique to study their ability to inhibit multidrug resistance of cancer cells. Hydrophilic doxorubicin (DOX) was selected as the model drug to be loaded into Tf-F127-PLA polymersomes. DOX loaded in Tf-F127-PLA polymersomes was released fast initially, followed by a slow release. The effect of the transferrin ligand density of Tf-F127-PLA/DOX polymersomes on their targeting properties was studied by both cytotoxicity and cellular uptake assays against A549 lung cancer cells. It was shown that Tf-F127-PLA/DOX polymersomes had better targeting ability than nontargeted drug-loaded polymersomes. Furthermore, Tf-F127-PLA/DOX polymersomes with 2% Tf molar content have more effective antitumor activity and a higher cellular uptake than those with 4 and 5% Tf molar content. 2% Tf-F127-PLA/DOX polymersomes also exhibited better anticancer ability in multidrug resistant cancer cells A549/ADR than nontargeted PLA-F127-PLA/DOX polymersomes. It was further proved that the endocytosis of polymersomes by A549/ADR cells was an energy-dependent endocytosis process, which was related to clathrin, macrocytosis, and caveolin. Also, the endocytosis of Tf-F127-PLA/DOX polymersomes was proven to be mediated by the transferrin receptor.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Inhibiting Multidrug Resistance with Transferrin-Targeted Polymersomes through Optimization of Ligand Density

Yi,

Li,

Gong

et al. 2023

Langmuir

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“…Non-spherical forms of micelles are not as stable as spherical shapes; however, a cross-linking in their structure may improve their stability and can potentially make stimulus-responsive micelles possible [ 225 ]. Some of the possible triggers for stimulus-responsive micelles include pH [ 227 – 228 ], temperature [ 229 ], enzymes [ 230 ], redox potential [ 231 ], light [ 232 ], US [ 233 ], electric fields [ 234 ], or magnetic fields [ 235 ]. Micelles can be fabricated combined with other NPs or biomolecules in order to have multiple features and functions including enhanced targeting, responsive particles, magnetic or fluorescent properties, all of which are important for theranostic applications [ 225 ].…”

Section: Reviewmentioning

confidence: 99%

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Fateh¹,

Moradi²,

Kohan³

et al. 2021

Beilstein J. Nanotechnol.

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The field of theranostics has been rapidly growing in recent years and nanotechnology has played a major role in this growth. Nanomaterials can be constructed to respond to a variety of different stimuli which can be internal (enzyme activity, redox potential, pH changes, temperature changes) or external (light, heat, magnetic fields, ultrasound). Theranostic nanomaterials can respond by producing an imaging signal and/or a therapeutic effect, which frequently involves cell death. Since ultrasound (US) is already well established as a clinical imaging modality, it is attractive to combine it with rationally designed nanoparticles for theranostics. The mechanisms of US interactions include cavitation microbubbles (MBs), acoustic droplet vaporization, acoustic radiation force, localized thermal effects, reactive oxygen species generation, sonoluminescence, and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors.

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Biomedical applications of magnetic nanoparticles

Anik

Hossain

et al. 2021

Magnetic Nanoparticle-Based Hybrid Materials

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Redox-responsive micelles self-assembled from multi-block copolymer for co-delivery of siRNA and hydrophobic anticancer drug

Cited by 6 publications

References 47 publications

Inhibiting Multidrug Resistance with Transferrin-Targeted Polymersomes through Optimization of Ligand Density

Inhibiting Multidrug Resistance with Transferrin-Targeted Polymersomes through Optimization of Ligand Density

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Biomedical applications of magnetic nanoparticles

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