Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter

Rovčanin, Branislav; Stojsavljević, Aleksandar; Kekić, Dušan; Gopčević, Kristina; Manojlović, Dragan; Jovanović, Milan; Knežević, Saša; Živaljević, Vladan; Diklić, Aleksandar; Paunović, Ivan

doi:10.1007/s12011-019-01995-x

Cited by 4 publications

(5 citation statements)

References 27 publications

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“…Demonstration of the presence of tissue oncometabolites specific to TC, such as high levels of lactate and choline and low levels of citrate, glutamine, and glutamate, have been reported as biomarkers for determining the metabolomic profile of preoperative thyroid nodules. Tissue lipids including cholesterol, choline, and phosphocholine have shown significant changes in tumor tissues compared to healthy tissue [ 44 ]. It has also been found that de novo synthesis of fatty acids is associated with tumorigenesis.…”

Section: Thyroid Cancer Diagnostics: Biomarkers and Methodologymentioning

confidence: 99%

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Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach

Berinde

Socaciu

et al. 2022

Diagnostics

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There are still many questions remaining about the etiopathogenesis of thyroid cancer, the most common type of endocrine neoplasia. Numerous occupational and environmental exposures have been shown to represent important risk factors that increase its incidence. Updated information about thyroid cancer diagnostics related to occupational and environmental risk factors is reviewed here, considering an integrated risk assessment approach; new data concerning thyroid cancer etiology and pathogenesis mechanisms, diagnostic biomarkers and methodologies, and risk factors involved in its pathogenesis are presented. A special emphasis is dedicated to specific occupational risk factors and to the association between environmental risk agents and thyroid cancer development. The occupational environment is taken into consideration, i.e., the current workplace and previous jobs, as well as data regarding risk factors, e.g., age, gender, family history, lifestyle, use of chemicals, or radiation exposure outside the workplace. Finally, an integrative approach is presented, underlying the need for an accurate Risk Assessment Matrix based on a systematic questionnaire. We propose a complex experimental design that contains different inclusion and exclusion criteria for patient groups, detailed working protocols for achieving coherent and sustainable, well-defined research stages from sample collection to the identification of biomarkers, with correlations between specific oncometabolites integrated into the Risk Assessment Matrix.

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Section: Thyroid Cancer Diagnostics: Biomarkers and Methodologymentioning

confidence: 99%

“…The level of Cu predicted the retrosternal localization of CG. This research presented results that provided a significant database for the development of new prognostic biomarkers for PTC and CG [ 44 ].…”

Section: Thyroid Cancer Diagnostics: Biomarkers and Methodologymentioning

confidence: 99%

Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach

Berinde

Socaciu

et al. 2022

Diagnostics

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“…A disturbed balance between serum OxS and antioxidant defence system markers is typically encountered in thyroid cancer patients compared to healthy individuals ( 119 , 120 , 122 , 123 ). The ineffective defence mechanism cannot neutralize ROS overproduction in thyroid cancer cells, leading to OxS ( 122 ).…”

Section: Thyroid Diseases and Oxsmentioning

confidence: 99%

The protective role of nutritional antioxidants against oxidative stress in thyroid disorders

et al. 2023

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An imbalance between pro-oxidative and antioxidative cellular mechanisms is oxidative stress (OxS) which may be systemic or organ-specific. Although OxS is a consequence of normal body and organ physiology, severely impaired oxidative homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells’ function and viability. The thyroid gland is an organ that exhibits both oxidative and antioxidative processes. In terms of OxS severity, the thyroid gland’s response could be physiological (i.e. hormone production and secretion) or pathological (i.e. development of diseases, such as goitre, thyroid cancer, or thyroiditis). Protective nutritional antioxidants may benefit defensive antioxidative systems in resolving pro-oxidative dominance and redox imbalance, preventing or delaying chronic thyroid diseases. This review provides information on nutritional antioxidants and their protective roles against impaired redox homeostasis in various thyroid pathologies. We also review novel findings related to the connection between the thyroid gland and gut microbiome and analyze the effects of probiotics with antioxidant properties on thyroid diseases.

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“…Many of them are involved in the pathways of synthesis and metabolism of thyroid hormones (Barysheva 2018;Hanif et al 2018), and in maintaining adequate thyroid function and preventing different diseases. Thyroid hormone metabolism is dependent on multiple regulatory proteins/enzymes, the expressions and functions of which are influenced by essential trace elements (Kolpak et al 2015;Stojsavljević et al 2018;Rovcanin et al 2020). The thyroid homeostasis of trace elements is dependent on their bioavailability, and disrupted circulatory levels can initiate the onset of benign and malignant thyroid diseases (Baltaci et al 2017;Liu et al 2018).…”

Section: Essential Trace Metals In Thyroid Homeostasismentioning

confidence: 99%

“…Effective treatment of TC requires a surgical approach as the only potential curative method, which can be supplemented with adjuvant radioactive iodine ( 131 I) therapy or, in some cases, with chemotherapy (Carling and Udelsman 2014). Nowadays, the molecular-genetic and biochemical characterization of thyroid tumors (Rovcanin et al 2016a(Rovcanin et al , 2016b(Rovcanin et al , 2019(Rovcanin et al , 2020) is taking place in many research centers (Hunt 2005;Nikiforov and Nikiforova 2011;Nixon et al 2017;Navas-Carrillo et al 2017), offering promising early diagnostic, prognostic, and therapeutic modalities, which could markedly improve the current position (D'Cruz et al 2018). Taking into account that TC is a frequent malignancy in most countries, further fundamental and applied research is necessary to provide valuable scientific data about the nature of the disease and treatment modalities, especially in terms of predicting disease evolution and identifying asymptomatic individuals.…”

Section: Thyroid Cancermentioning

confidence: 99%

Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

Stojsavljević

Rovčanin

2021

Expo Health

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Most investigations conducted in the last four decades have shown a rising incidence of thyroid diseases worldwide. Although our knowledge of the molecular pathways of thyroid disease has advanced, the initial steps in thyroid cancerogenesis have not yet been sufficiently elucidated. However, recent human biomonitoring studies have shown that specific trace metals, as major endocrine disrupters, could be considered as risk factors for impaired thyroid health and the evolution of thyroid cancer (TC). In this review, the impact of essential and toxic trace metals from the environment on thyroid health and TC was evaluated. Furthermore, this review clarifies which trace metals most likely contribute to the etiology of TC. Biomarkers based on trace metal ratios are proposed. Overall, the information described in this review is expected to be useful in planning future fundamental and applied studies on the endocrine toxicity of essential and toxic trace metals.

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Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter

Cited by 4 publications

References 27 publications

Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach

Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach

The protective role of nutritional antioxidants against oxidative stress in thyroid disorders

Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

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