Reduced adiponectin levels in patients with COVID‐19 acute respiratory failure: A case‐control study

Kearns, Seán; Ahern, Katelyn W.; Patrie, James T.; Horton, William B.; Harris, Thurl E.; Kadl, Alexandra

doi:10.14814/phy2.14843

Cited by 30 publications

(42 citation statements)

References 14 publications

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“…Complete cases were considered. The inclusion of variables in the final models were based on the following criteria: 1) significance in Kaplan-Meier and/or univariable analyses; 2) association with survival according to the previous studies [9][10][11][12][13][14]; 3) clinical knowledge.…”

Section: Discussionmentioning

confidence: 99%

Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia

et al. 2022

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COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, laboratory and CT scan characteristics associated with high risk of COVID-19-related death outcome in the cohort of severely-ill patients in Russia. The data obtained reveal that elevated dead lymphocyte counts, decreased early apoptotic lymphocytes, decreased CD14+/HLA-Dr+ monocytes, increased expression of JNK in PBMCs, elevated IL-17 and decreased PAI-1 serum levels are associated with a high risk of COVID-19-related mortality thus suggesting them to be new prognostic factors. This set of determinants could be used as early predictors of potentially severe course of COVID-19 for trials of prevention or timely treatment.

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Section: Discussionmentioning

confidence: 99%

Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia

et al. 2022

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“…Second, phototherapy with fullspectrum light would ameliorate the adipose tissue dysfunction, which causes insulin resistance, proinflammatory cytokine release, and altered adipokine production [34]. Reduced expression of adiponectin is a risk factor of metabolic syndrome, and a recent case-control study pointed to the link between obesity and COVID-19 respiratory failure in terms of adiponectin levels [85]. Our previous study demonstrated the elevation of adiponectin by phototherapy with full-spectrum light [34].…”

Section: Hypothesis: Potential Impact Of Phototherapy With Full-spectrum Light On the Covid-19 Pandemicmentioning

confidence: 98%

Sunlight Exposure and Phototherapy: Perspectives for Healthy Aging in an Era of COVID-19

Nakano

Chiang

Chen

et al. 2021

IJERPH

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Most humans depend on sunlight exposure to satisfy their requirements for vitamin D3. However, the destruction of the ozone layer in the past few decades has increased the risk of skin aging and wrinkling caused by excessive exposure to ultraviolet (UV) radiation, which may also promote the risk of skin cancer development. The promotion of public health recommendations to avoid sunlight exposure would reduce the risk of skin cancer, but it would also enhance the risk of vitamin D3 insufficiency/deficiency, which may cause disease development and progression. In addition, the ongoing global COVID-19 pandemic may further reduce sunlight exposure due to stay-at-home policies, resulting in difficulty in active and healthy aging. In this review article, we performed a literature search in PubMed and provided an overview of basic and clinical data regarding the impact of sunlight exposure and vitamin D3 on public health. We also discuss the potential mechanisms and clinical value of phototherapy with a full-spectrum light (notably blue, red, and near-infrared light) as an alternative to sunlight exposure, which may contribute to combating COVID-19 and promoting active and healthy aging in current aged/superaged societies.

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“…It has been postulated that decrease in adiponectin in obesity may contribute to respiratory failure in COVID-19 [ 10 ]. In a recent study, decrease in plasma levels of adiponectin was observed in 12 COVID-19 patients with respiratory failure compared to non-COVID patients with respiratory failure [ 370 ]. It appears that leptin and adiponectin have opposite effects on vascular endothelium, metabolism, immune response, and inflammation, and an inverse pattern of expression with leptin showing an increase and adiponectin decreasing in obesity [ 364 ]; the ratio of these two adipokines in circulation might be important in the pathophysiology of COVID-19.…”

Section: Why Is Obesity a Risk For Covid-19 ?—Pathways And Molecular ...mentioning

confidence: 99%

Mechanisms contributing to adverse outcomes of COVID-19 in obesity

et al. 2022

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A growing amount of epidemiological data from multiple countries indicate an increased prevalence of obesity, more importantly central obesity, among hospitalized subjects with COVID-19. This suggests that obesity is a major factor contributing to adverse outcome of the disease. As it is a metabolic disorder with dysregulated immune and endocrine function, it is logical that dysfunctional metabolism contributes to the mechanisms behind obesity being a risk factor for adverse outcome in COVID-19. Emerging data suggest that in obese subjects, (a) the molecular mechanisms of viral entry and spread mediated through ACE2 receptor, a multifunctional host cell protein which links to cellular homeostasis mechanisms, are affected. This includes perturbation of the physiological renin-angiotensin system pathway causing pro-inflammatory and pro-thrombotic challenges (b) existent metabolic overload and ER stress-induced UPR pathway make obese subjects vulnerable to severe COVID-19, (c) host cell response is altered involving reprogramming of metabolism and epigenetic mechanisms involving microRNAs in line with changes in obesity, and (d) adiposopathy with altered endocrine, adipokine, and cytokine profile contributes to altered immune cell metabolism, systemic inflammation, and vascular endothelial dysfunction, exacerbating COVID-19 pathology. In this review, we have examined the available literature on the underlying mechanisms contributing to obesity being a risk for adverse outcome in COVID-19.

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Reduced adiponectin levels in patients with COVID‐19 acute respiratory failure: A case‐control study

Cited by 30 publications

References 14 publications

Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia

Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia

Sunlight Exposure and Phototherapy: Perspectives for Healthy Aging in an Era of COVID-19

Mechanisms contributing to adverse outcomes of COVID-19 in obesity

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