Reduced alpha-gamma phase amplitude coupling over right parietal cortex is associated with implicit visuomotor sequence learning

Tzvi, Elinor; Verleger, Rolf; Münte, Thomas F.; Krämer, Ulrike M.

doi:10.1016/j.neuroimage.2016.07.019

Cited by 38 publications

(55 citation statements)

References 57 publications

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“…Furthermore, in their study the improvement of reaction times varied linearly with the amount of beta desynchronisation, particularly during consolidation. Another recent study reported a reduction in alpha and theta power over posterior areas with learning for sequenced blocks (compared to random blocks), together with a reduction in alpha‐to‐low‐gamma phase–amplitude coupling over right parietal and bilateral frontal areas (Tzvi et al ., ). The authors suggest that the reduced phase–amplitude coupling reflects a shift away from visually guided motor selection, towards implementation of the learned motor sequence.…”

Section: Discussionmentioning

confidence: 99%

Temporal alignment of anticipatory motor cortical beta lateralisation in hidden visual‐motor sequences

Heideman

Ede

Nobre

2017

Eur J of Neuroscience

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Performance improves when participants respond to events that are structured in repeating sequences, suggesting that learning can lead to proactive anticipatory preparation. Whereas most sequence-learning studies have emphasised spatial structure, most sequences also contain a prominent temporal structure. We used MEG to investigate spatial and temporal anticipatory neural dynamics in a modified serial reaction time (SRT) task. Performance and brain activity were compared between blocks with learned spatial-temporal sequences and blocks with new sequences. After confirming a strong behavioural benefit of spatial-temporal predictability, we show lateralisation of beta oscillations in anticipation of the response associated with the upcoming target location and show that this also aligns to the expected timing of these forthcoming events. This effect was found both when comparing between repeated (learned) and new (unlearned) sequences, as well as when comparing targets that were expected after short vs. long intervals within the repeated (learned) sequence. Our findings suggest that learning of spatial-temporal structure leads to proactive and dynamic modulation of motor cortical excitability in anticipation of both the location and timing of events that are relevant to guide action.

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Section: Discussionmentioning

confidence: 99%

Temporal alignment of anticipatory motor cortical beta lateralisation in hidden visual‐motor sequences

Heideman

Ede

Nobre

2017

Eur J of Neuroscience

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“…The basal ganglia are involved in the regulation of non-motor as well as motor sequences, and motor sequence learning (Vakil et al, 2000 ; Exner et al, 2002 ; Tzvi et al, 2014 , 2015 , 2016 ; Fermin et al, 2016 ). Although the activation of the basal ganglia for the training period in our study might reflect on-line learning processes, we cannot distinguish activation linked to attentional demands and on-line error correction (adaptation).…”

Section: Discussionmentioning

confidence: 99%

Effect of Error Augmentation on Brain Activation and Motor Learning of a Complex Locomotor Task

et al. 2017

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Up to date, the functional gains obtained after robot-aided gait rehabilitation training are limited. Error augmenting strategies have a great potential to enhance motor learning of simple motor tasks. However, little is known about the effect of these error modulating strategies on complex tasks, such as relearning to walk after a neurologic accident. Additionally, neuroimaging evaluation of brain regions involved in learning processes could provide valuable information on behavioral outcomes. We investigated the effect of robotic training strategies that augment errors—error amplification and random force disturbance—and training without perturbations on brain activation and motor learning of a complex locomotor task. Thirty-four healthy subjects performed the experiment with a robotic stepper (MARCOS) in a 1.5 T MR scanner. The task consisted in tracking a Lissajous figure presented on a display by coordinating the legs in a gait-like movement pattern. Behavioral results showed that training without perturbations enhanced motor learning in initially less skilled subjects, while error amplification benefited better-skilled subjects. Training with error amplification, however, hampered transfer of learning. Randomly disturbing forces induced learning and promoted transfer in all subjects, probably because the unexpected forces increased subjects' attention. Functional MRI revealed main effects of training strategy and skill level during training. A main effect of training strategy was seen in brain regions typically associated with motor control and learning, such as, the basal ganglia, cerebellum, intraparietal sulcus, and angular gyrus. Especially, random disturbance and no perturbation lead to stronger brain activation in similar brain regions than error amplification. Skill-level related effects were observed in the IPS, in parts of the superior parietal lobe (SPL), i.e., precuneus, and temporal cortex. These neuroimaging findings indicate that gait-like motor learning depends on interplay between subcortical, cerebellar, and fronto-parietal brain regions. An interesting observation was the low activation observed in the brain's reward system after training with error amplification compared to training without perturbations. Our results suggest that to enhance learning of a locomotor task, errors should be augmented based on subjects' skill level. The impacts of these strategies on motor learning, brain activation, and motivation in neurological patients need further investigation.

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“…As phase-amplitude coupling is believed to play a fundamental role in the transfer of neural information across diverse spatial and temporal processing scales, thereby serving the dynamic integration of global computations with fast local processing, it may be extremely relevant for cognitive functioning [42]. Recent evidence has started to support this claim by hinting at its functional significance for visual perception [26], feedback processing [57], memory recall [58], visuomotor mapping [59] and movement planning and execution [60].…”

Section: Discussionmentioning

confidence: 99%

Phase-Amplitude Coupling of Neural Oscillations can be Effectively Probed with Concurrent TMS-EEG

Glim

Okazaki

Nakagawa

et al. 2018

Preprint

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Despite the widespread use of transcranial magnetic stimulation (TMS), knowledge of its neurophysiological mode of action is still incomplete. Recently, TMS has been proposed to synchronise neural oscillators, and to thereby increase the detectability of corresponding oscillations at the population level. As oscillations in the human brain are known to interact within nested hierarchies via phase-amplitude coupling, TMS might also be able to increase the macroscopic detectability of such coupling. In a concurrent TMS-electroencephalography study, we therefore examined the technique's influence on theta-gamma, alpha-gamma and beta-gamma phase-amplitude coupling by delivering single-pulse TMS (sTMS) and repetitive TMS (rTMS) over the left motor cortex and right visual cortex of healthy participants. The rTMS pulse trains were of 5 Hz, 11 Hz and 23 Hz for the three coupling variations, respectively. Relative to sham stimulation, all conditions showed transient but significant increases in phase-amplitude coupling at the stimulation site. In addition, we observed enhanced coupling over various other cortical sites, with a more extensive propagation during rTMS than during sTMS. By indicating that scalp-recorded phase-amplitude coupling can be effectively probed with TMS, these findings open the door to the technique's application in manipulative dissections of such coupling during human cognition and behaviour.

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Reduced alpha-gamma phase amplitude coupling over right parietal cortex is associated with implicit visuomotor sequence learning

Cited by 38 publications

References 57 publications

Temporal alignment of anticipatory motor cortical beta lateralisation in hidden visual‐motor sequences

Temporal alignment of anticipatory motor cortical beta lateralisation in hidden visual‐motor sequences

Effect of Error Augmentation on Brain Activation and Motor Learning of a Complex Locomotor Task

Phase-Amplitude Coupling of Neural Oscillations can be Effectively Probed with Concurrent TMS-EEG

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