Reduced Amygdala Microglial Expression of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B (TrkB) in a Rat Model of Poststroke Depression

Zhu, Hanxiao; Cheng, Ling Jie; Yang, Ri-Wei Ou; Li, Yangyang; Liu, Jian; Dai, Dan; Wang, Wei; Yang, Ning; Li, Yun

doi:10.12659/msm.926323

Cited by 8 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, PSD is associated with dysregulation of BDNF, an essential neurotrophic factor in the hippocampus, cerebral cortex, and cerebellum. It binds to tyrosine kinase receptor B (TrkB) and plays a crucial neurotrophic role [58][59][60][61]. Its functions include nourishing damaged neurons, regulating neural plasticity, depicting a vital role in the survival, differentiation, growth, and postinjury repair of neurons, and participating in the initiation and development of depression, regarded as a landmark indicator for the diagnosis of depression [62,63].…”

mentioning

confidence: 99%

Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence

Xia

Gong

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Poststroke depression (PSD) does not exist before and occurs after the stroke. PSD can appear shortly after the onset of stroke or be observed in the weeks and months after the acute or subacute phase of stroke. The pathogenesis of PSD is unclear, resulting in poor treatment effects. With research advancement, immunoactive cells in the central nervous system, particularly microglia, play a role in the occurrence and development of PSD. Microglia affects the homeostasis of the central nervous system through various factors, leading to the occurrence of depression. The research progress of microglia in PSD has been summarized to review the evidence regarding the pathogenesis and treatment target of PSD in the future.

show abstract

mentioning

confidence: 99%

Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence

Xia

Gong

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…That said although sparse, some recent findings are consistent with microglia expressing TrkB. Specifically, TrkB labeling was found to be co-localized in IBA1+, CD11b+, and OX-42+ rodent brain sections and levels were affected by the age of the animal, as well as being altered in the context of poststroke depression or with exposure to cyclophosphamide (Ding et al, 2020;Wu et al, 2020;Zhu et al, 2020).…”

Section: Introductionmentioning

confidence: 77%

Brain-derived neurotrophic factor (BDNF) has direct anti-inflammatory effects on microglia

Charlton

Prowse

McFee

et al. 2023

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Microglia are the primary immunocompetent cells that protect the brain from environmental stressors, but can also be driven to release pro-inflammatory cytokines and induce a cytotoxic environment. Brain-derived neurotrophic factor (BDNF) is important for the regulation of plasticity, synapse formation, and general neuronal health. Yet, little is known about how BDNF impacts microglial activity. We hypothesized that BDNF would have a direct modulatory effect on primary cortical (Postnatal Day 1-3: P1-3) microglia and (Embryonic Day 16: E16) neuronal cultures in the context of a bacterial endotoxin. To this end, we found that a BDNF treatment following LPS-induced inflammation had a marked anti-inflammatory effect, reversing the release of both IL-6 and TNF-α in cortical primary microglia. This modulatory effect was transferrable to cortical primary neurons, such that LPS-activated microglial media was able produce an inflammatory effect when added to a separate neuronal culture, and again, BDNF priming attenuated this effect. BDNF also reversed the overall cytotoxic impact of LPS exposure in microglia. We speculate that BDNF can directly play a role in regulating microglia state and hence, influence microglia-neuron interactions.

show abstract

“…Microglia signal transduction and transcription factor 3 (STAT3) regulate the synaptic function of macrophage colony-stimulating factor (M-CSF) in neurons that in turn that upregulate BDNF expression, which is central to its antidepressant role [127]. In addition, the downregulation of BDNF and TrkB in microglia can also lead to depressed behavior [128]. Chronic stress-induced depression-like and anxiety-like behavior were not only associated with microglia activation but also related to hippocampal neuroinflammation [129].…”

Section: Glial Cellsmentioning

confidence: 99%

Antidepressant-like Effects of Representative Types of Food and Their Possible Mechanisms

Piao,

Wang,

Zhang

et al. 2023

Molecules

View full text Add to dashboard Cite

Depression is a mental disorder characterized by low mood, lack of motivation, negative cognitive outlook, and sleep problems. Suicide may occur in severe cases, although suicidal thoughts are not seen in all cases. Globally, an estimated 350 million individuals grapple with depression, as reported by the World Health Organization. At present, drug and psychological treatments are the main treatments, but they produce insufficient responses in many patients and fail to work at all in many others. Consequently, treating depression has long been an important topic in society. Given the escalating prevalence of depression, a comprehensive strategy for managing its symptoms and impacts has garnered significant attention. In this context, nutritional psychiatry emerges as a promising avenue. Extensive research has underscored the potential benefits of a well-rounded diet rich in fruits, vegetables, fish, and meat in alleviating depressive symptoms. However, the intricate mechanisms linking dietary interventions to brain function alterations remain largely unexplored. This review delves into the intricate relationship between dietary patterns and depression, while exploring the plausible mechanisms underlying the impact of dietary interventions on depression management. As we endeavor to unveil the pathways through which nutrition influences mental well-being, a holistic perspective that encompasses multidisciplinary strategies gains prominence, potentially reshaping how we approach and address depression.

show abstract

Reduced Amygdala Microglial Expression of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B (TrkB) in a Rat Model of Poststroke Depression

Cited by 8 publications

References 36 publications

Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence

Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence

Brain-derived neurotrophic factor (BDNF) has direct anti-inflammatory effects on microglia

Antidepressant-like Effects of Representative Types of Food and Their Possible Mechanisms

Contact Info

Product

Resources

About