Reduced Ascorbic-Acid Excretion and Oral Contraceptives

Harris, A.B.; Hartley, J.E.; Moor, Angela

doi:10.1016/s0140-6736(73)93030-4

Cited by 21 publications

(5 citation statements)

References 11 publications

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“…In rats, administration of ACTH or cortisone has been shown to lower plasma and hepatic levels of the vitamin. In addition, women taking contraceptive steroids may absorb less vitamin or may metabolize it more quickly and thus may require more than 60 mg/d 30–32 . Diabetes may also affect vitamin C requirements 33 .…”

Section: Needmentioning

confidence: 99%

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Vitamin C

Berdanier¹

2022

Nutr Today

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Vitamin C or ascorbic acid is a required nutrient for humans. Should this vitamin be lacking in the human diet, the disease, scurvy, will develop. Scurvy has been described since ancient times, and its cure through the provision of ascorbic acid has had a torturous path. Vitamin C is an important contributor to the overall regulation of the redox state of the body due to its easy interconversion from an oxidized form to a reduced form and vice versa. It is important for collagen synthesis and serves as an essential coenzyme to a wide variety of enzymes. Not all animals require dietary intakes of the vitamin, but humans, some primates, guinea pigs, fruit bats, and some fish species do. The recommended daily intakes for this nutrient are well established.

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Section: Needmentioning

confidence: 99%

“…In addition, women taking contraceptive steroids may absorb less vitamin or may metabolize it more quickly and thus may require more than 60 mg/d. [30][31][32] Diabetes may also affect vitamin C requirements. 33 Details on these intakes can be found at www.nap.edu.…”

Section: Toxicitymentioning

confidence: 99%

Vitamin C

Berdanier¹

2022

Nutr Today

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“…Women using oral contraceptives have been shown to have reduced vitamin C concentrations in plasma, leucocytes [116], and urine [117]. The clinical significance and cause of this is, however, uncertain.…”

Section: Vitamin C (Ascorbic Acid)mentioning

confidence: 99%

Metabolic effects of combined oral contraceptives

Gillmer¹

1989

Contraception

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“…Human studies have revealed that plasma ascorbate reserves are depleted in a number of conditions such as inflammation [1,2], surgical trauma [3,4], myocardial infarction [5], smoking [6], use of oral contraceptives [7][8][9] , and thermal burns [10]. Similarly, estrogen administration to female guinea pigs reduced the plasma ascorbate levels [11].…”

mentioning

confidence: 99%

N-Nitrosodiethylamine Induced Changes in Levels, Metabolism, and Urinary Excretion of Ascorbic Acid in Guinea Pigs.

Kapur

Khanduja

Majid

et al. 1991

J. Clin. Biochem. Nutr.

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Treatment of male guinea pigs with the potent chemical carcinogen N-nitrosodiethylamine (NDEA) at an intraperitoneal dose of 40 mg/kg body weight for three consecutive days resulted in a significant decrease in the levels of ascorbic acid in liver, lungs, kidneys, and adrenal glands. The decrease in the brain and plasma was, however, not significant. Radiorespirometric, distribution, and urinary excretion studies conducted with the use of L-[carboxyl-14C ] ascorbic acid revealed that a possible mechanism responsible for depletion of the body ascorbate store by NDEA might be the enhanced metabolic degradation of ascorbic acid into CO2, and other metabolites that are excreted through urine.

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Reduced Ascorbic-Acid Excretion and Oral Contraceptives

Cited by 21 publications

References 11 publications

Vitamin C

Vitamin C

Metabolic effects of combined oral contraceptives

N-Nitrosodiethylamine Induced Changes in Levels, Metabolism, and Urinary Excretion of Ascorbic Acid in Guinea Pigs.

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