Reduced bone mineral density in nigerian women: A Prevalence Study

Njeze, NR; Agwu-Umahi, Olanike; Ezeofor, Salome Nwaelom; Arinze-Onyia, Sussan U.; Njeze, Nneze C; Akpagbula, Damaris Ulugo; Madu, Kenechi

doi:10.4103/njot.njot_32_18

Cited by 2 publications

(2 citation statements)

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“…The secondary causes of MBD reported to be common in the population studied include osteoporosis, indiscriminate use of vitamin D analogues and calcium based medications. [30][31][32][33] Exclusion of individuals with Diabetes mellitus may be responsible for the low prevalence of low turn over MBD in this study. Factors that increase the risk of low turn over CKM-MBD include Diabetes mellitus, the use of vitamin D analogues and phosphate binders.…”

Section: Resultsmentioning

confidence: 99%

Fibroblast Growth Factor 23 (FGF 23) and intact parathyroid hormone (iPTH) as markers of mineral bone disease among Nigerians with non-diabetic kidney disease

Raji¹,

Ajayi²,

Adeoye³

et al. 2022

Afr H. Sci.

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Background: Excess cardiovascular burden in patients with chronic kidney disease (CKD) has been attributed to the occurrence of CKD–Mineral Bone Disease (CKD – MBD). This study aimed to determine the spectrum of CKD-MBD among Nigerians with CKD using Fibroblast Growth Factor 23 (FGF 23) and intact Parathyroid Hormone (iPTH). Methods: Cross sectional survey of 105 patients with non-diabetic CKD and 104 controls. Information obtained were demographics, aetiology of CKD, features of CKD-MBD. Serum iPTH and FGF 23 were assayed. Results: The mean ages were 48.7±15.3 vs 48.6±17.4 years while 54.7% and 45.2% were males for cases and controls, respectively. The mean plasma FGF 23 (392.8±35.3 vs 133.8±22.7 RU/mL and plasma iPTH (289±25.6 vs 118±10.8 ng/L, respectively. The frequency of elevated FGF 23 (45.7% vs 24.0%, p<0.01) and abnormal iPTH (53.3% vs 14.1%, p- 0.01) were higher in cases. The prevalence of MBD were (59.0% vs 14.4%, p<0.01) in cases and controls while dialysis status OR 2.94, 95% CI (1.2803–5.3645), and elevated FGF 23 OR, 1.87, 95% CI (1.1782–5.4291) were associated with CKD-MBD. Conclusion: The study demonstrated high prevalence of CKD-MBD among patients with non-diabetic CKD while FGF23 and iPTH were useful assays in the diagnosis of CKD-MBD among Nigerians with CKD. Keywords: CKD; mineral bone disease; diagnostic; FGF 23; parathyroid hormone.

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Section: Resultsmentioning

confidence: 99%

Fibroblast Growth Factor 23 (FGF 23) and intact parathyroid hormone (iPTH) as markers of mineral bone disease among Nigerians with non-diabetic kidney disease

Raji¹,

Ajayi²,

Adeoye³

et al. 2022

Afr H. Sci.

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“…Our findings in relation to a positive significant association of BMI and BMD are in agreement to the results of Wilson et al, 34 who revealed that a higher BMI is associated with a higher BMD and this is observed in premenopausal and even in younger women. In addition, Njeze et al 35 observed that obesity is traditionally viewed to be beneficial to bone health because there is an established positive effect of mechanical loading as a result of the weight of the body on formation of bone. Some studies showed conflicting evidence, a higher body mass has a significant risk for fragility fracture, especially for fractures occurring at sites other than the hip.…”

Section: Discussionmentioning

confidence: 99%

<p>Screening for Bone Mineral Density and Assessment Knowledge Level of Low Peak Bone Risk Factors and Preventive Practices Among Kuwaiti Future Mothers</p>

Al-Ayyadhi¹,

Refaat²,

Ibrahim³

et al. 2020

JMDH

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Background Attaining greater peak bone mass (PBM) prior to the onset of bone loss is getting increasing public health attention as healthy strong bones are essential to maintain our life. Females are more susceptible to bone loss. Knowledge and awareness about low peak bone mass and its related risk factors are important contributors to its preventive behavior. Objective To screen apparently healthy young Kuwaiti future mothers for low bone mineral density (BMD) and to assess their knowledge level about determinants of PBM and preventive practices. Methods A cross-sectional comparative study on 445 eligible women aged 18–35 years (either students or employees from Kuwait University) was performed. Data on socio-demographic and lifestyle variables were obtained by a semi-structured questionnaire. Their knowledge was assessed using the modified Osteoporosis Knowledge Assessment Tool (OKAT). Bone mineral Density (BMD) was measured using Quantitative Ultrasonography (QUS). Results More than half (59.3%) of females had poor knowledge. A statistically significant relation was noted between the overall knowledge score and age, college, occupation, and socioeconomic class ( P <0.05 for each). Only 13.9% have low Z-score by QUS. By logistic regression, less carbonated beverages and coffee consumption positively affect BMD, while inadequate exercises level, indoor exposure to sunlight, and less frequency of brisk walking negatively affect BMD. Conclusion Unacceptable knowledge score significantly associated with BMD Z-score status. More attention should be devoted to education programs targeting adolescents and young females to promote knowledge about PBM and practice towards accrual and maintenance of bone health.

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Reduced bone mineral density in nigerian women: A Prevalence Study

Cited by 2 publications

References 1 publication

Fibroblast Growth Factor 23 (FGF 23) and intact parathyroid hormone (iPTH) as markers of mineral bone disease among Nigerians with non-diabetic kidney disease

Fibroblast Growth Factor 23 (FGF 23) and intact parathyroid hormone (iPTH) as markers of mineral bone disease among Nigerians with non-diabetic kidney disease

<p>Screening for Bone Mineral Density and Assessment Knowledge Level of Low Peak Bone Risk Factors and Preventive Practices Among Kuwaiti Future Mothers</p>

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