Reduced dimensionality hyphenated NMR experiments for the structure determination of compounds in mixtures

Abstract

A suite of NMR experiments using combined chemical shifts to separate resonances in two rather than three dimensions.

19F-centred NMR analysis of mono-fluorinated compounds

“…Interleaved acquisition of two spectra, differing by 90 in the phase of the last 90 13 C pulse of the pulse sequence, generates inphase and anti-phase F 1 doublets, respectively, allowing spectra to be simplied by spectral editing 58,59 as illustrated in Fig. S5.…”

New 19F NMR methodology reveals structures of molecules in complex mixtures of fluorinated compounds

“…Finally, the outcome of a simultaneous H 1 C n F correlation is illustrated in ⑤ (Fig.4). This intrinsically 3D experiment has been modified using the principles of reduced dimensionality83,84 to produce a (3, 2)D experiment. Here, the13 C chemical shift is coded in the 1 H dimension by the width of the F 1 -doublet.…”