2014
DOI: 10.1007/s00213-014-3712-1
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Reduced dopamine release in the nucleus accumbens core of adult rats following adolescent binge alcohol exposure: age and dose-dependent analysis

Abstract: Rationale Alcohol use in adolescence is one of the most significant predictors of alcohol dependence in adulthood, yet the neurochemical mechanisms underlying this heightened vulnerability remain unknown. Whereas research has focused on characterizing adaptations in the mesolimbic dopamine (DA) system following ethanol exposure in adolescence, whether these changes persist into adulthood has yet to be determined. Objectives To investigate the effects of binge-intermittent ethanol administration in adolescenc… Show more

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Cited by 22 publications
(14 citation statements)
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“…Given the normative course of development of this region throughout adolescence, it is not surprising that adolescents exhibit ontogenetic alterations in many aspects of reward-related behavior that are thought to be influenced by dopaminergic activity in the nAc such as enhanced goal-directed behavior (e.g., Anderson et al, 2013; Serlin and Torregrossa, 2015), expending more effort for larger rewards (e.g., Friemel et al, 2010; Stolyarova and Izquierdo, 2015), and altered responding to drug- and reward-associated cues (e.g., Anderson et al, 2013; Doherty et al, 2009; Li and Frantz, 2009). Furthermore, the responsiveness of dopaminergic activity in the nAc to drug-related rewards (for review see Volkow and Morales, 2015) is consistent with evidence that this region may be especially vulnerable to lasting modification by adolescent exposure to drugs of abuse (e.g., Catlow and Kirstein, 2007; Smith et al, 2015; Zandy et al, 2015), as well as to natural rewards, such as sucrose overconsumption (e.g., Naneix et al, 2016). …”
Section: The Neurobiology Of Rewards and Aversions During Adolescencesupporting
confidence: 70%
“…Given the normative course of development of this region throughout adolescence, it is not surprising that adolescents exhibit ontogenetic alterations in many aspects of reward-related behavior that are thought to be influenced by dopaminergic activity in the nAc such as enhanced goal-directed behavior (e.g., Anderson et al, 2013; Serlin and Torregrossa, 2015), expending more effort for larger rewards (e.g., Friemel et al, 2010; Stolyarova and Izquierdo, 2015), and altered responding to drug- and reward-associated cues (e.g., Anderson et al, 2013; Doherty et al, 2009; Li and Frantz, 2009). Furthermore, the responsiveness of dopaminergic activity in the nAc to drug-related rewards (for review see Volkow and Morales, 2015) is consistent with evidence that this region may be especially vulnerable to lasting modification by adolescent exposure to drugs of abuse (e.g., Catlow and Kirstein, 2007; Smith et al, 2015; Zandy et al, 2015), as well as to natural rewards, such as sucrose overconsumption (e.g., Naneix et al, 2016). …”
Section: The Neurobiology Of Rewards and Aversions During Adolescencesupporting
confidence: 70%
“…Diminished neuronal activation in this region, a likely result of sustained stimulation during drug exposure and withdrawal (Luscher and Malenka, 2011), reduces striatal dopamine (DA) release and may contribute to lower reward sensitivity in addiction (Volkow et al, 2010). Remarkably, decreased DA release in the nucleus accumbens (NAc) was evidenced as a long-term consequence of adolescent binge alcohol exposure (Zandy et al, 2015). Moreover, social interactions recruit brain reward circuitry (Becker et al, 2014; Gunaydin et al, 2014; Trezza et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…[29][30][31] This pattern of responses is highly consistent with the alterations in the dopaminergic system following adolescent but not adult exposure to bingelike levels of ethanol. 32,33 Exposure to alcohol during early adolescence strongly drives dopamine release. However, adolescent alcohol appears to blunt dopaminergic signaling and responses to alcohol in adulthood.…”
Section: Weil Et Almentioning
confidence: 99%
“…33,34 Importantly, this effect was highly age specific as exposure to alcohol during later developmental stages reduced both the immediate dopamine efflux and the sensitization of the dopaminergic system to later ethanol exposure. 32 It seems possible, therefore, that the injury-induced surge of dopamine release throughout the forebrain sensitizes reward circuitry in a similar manner. Combining these data with the evidence for later long-term hypodopaminergia following TBI strongly suggests that increases in alcohol drinking behavior are mediated by three overlapping events.…”
Section: Weil Et Almentioning
confidence: 99%
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