Reduced expression of systemic proinflammatory and myocardial biomarkers after off-pump versus on-pump coronary artery bypass surgery: A prospective randomized study

Trimetazidina e resposta inflamatória em cirurgia de revascularização do miocárdio

“…In the present study, no post-operative complications were observed in the groups during the followup period until hospital discharge (15 days). In addition, neither a longer ICU length of stay nor the use of vasoactive amines was required in the presence of CRP levels over those reported by Serrano et al 11 .…”

“…Studies with several protocols have assessed markers involved in the pathophysiology of the inflammatory response, which still lacks effective preventive management. Currently, the substances assessed on trials have not proved to completely reduce the inflammatory complications in CABG-ECC 10,11 .…”

“…Several reviews of prospective and randomized trials and meta-analyses of randomized trials have compared the proand anti-inflammatory effects of that procedure, and have evidenced the smaller inflammatory damages in procedures without ECC. However, no reduction in the major clinical outcomes, such as mortality, stroke, myocardial infarction, and need for reintervention, has been observed 1,11,[25][26][27] .…”

Current Evidence of On-Pump Versus Off-Pump Coronary Artery By-Pass Surgery

“…However, many randomized studies provide evidence of a lower, subclinical release of biochemical markers of myocardial damage among patient operated using OPCAB (12,25,(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42). This tendency is very robust across the different studies, and it is even preset in a study that showed a significantly higher proportion of graft occlusions in the OPCAB group (25).…”

The effects of single and dual reservoired oxygenators on inflammatory response in cardiopulmonary bypass

“…[2,3] Kardiyak, pulmoner, renal, serebral fonksiyonlarda önemli patolojik değişiklikler ve organ disfonksiyonları gibi majör komplikasyonlar ortaya çıkabilir. [4][5][6] Kardiyopulmoner baypas sırasında kanın aspiratör-den venöz rezervuara çekilmesi kırmızı kan hücreleri üzerinde travmatik etki yapar. Perikard içinde biriken kanda enflamauvar mediatörler ve plazma serbest hemoglobin seviyesi yüksektir.…”