Reduced fiber integrity and cognitive control in adolescents with internet gaming disorder

Xing, Lihong; Yuan, Kai; Bi, Yanzhi; Yin, Junsen; Cai, Chenxi; Feng, Dan; Li, Yangding; Song, Min Kyung; Wang, Hongmei; Yu, Dahua; Xue, Ting; Jin, Chenwang; Qin, Wei; Tian, Jie

doi:10.1016/j.brainres.2014.08.044

Cited by 61 publications

(47 citation statements)

References 45 publications

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“…Cognitive control deficits in IGD were measured by Stroop color‐word task as described in our previous IGD studies (Yuan et al ; Yuan et al ; Xing et al ), which has been used widely in SUD (Xu et al ) and implemented using the E‐prime 2.0 software (http://www.pstnet.com/eprime.cfm). In detail, this task employed a block design with three conditions: congruent, incongruent and rest.…”

Section: Methodsmentioning

confidence: 99%

“…Regardless of whether IGD is conceptualized as a behavioral addiction, it is speculated to be associated with impaired cognitive control, e.g. longer reaction time (Dong et al ) and more response errors during incongruent conditions in Stroop task (Yuan et al ; Yuan et al ; Xing et al ; Yuan et al ). Cognitive control refers to the ability to allow for appropriate actions by suppressing inappropriate or irrelevant sensory or motor representations (Kerns et al ; Matsumoto & Tanaka ).…”

Section: Introductionmentioning

confidence: 99%

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Frontostriatal circuits, resting state functional connectivity and cognitive control in internet gaming disorder

et al. 2016

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Converging evidence has identified cognitive control deficits in internet gaming disorder (IGD). Recently, mounting evidence had revealed that resting state functional connectivity (RSFC) and structural connectivity of frontostriatal circuits could modulate cognitive control in healthy individuals. Unfortunately, relatively little is known about the thoroughly circuit-level characterization of the frontostriatal pathways (both the dorsal and ventral striatum) during resting-state and their association with cognitive control in IGD. In the current study, the differences of striatum volume and RSFC networks were investigated between 43 young IGD individuals and 44 healthy controls. Meanwhile, cognitive control deficits were assessed by Stroop task performances. The neuroimaging findings were then correlated with the Stroop task behaviors. In IGD subjects, we demonstrated an increased volume of right caudate and nucleus accumbens (NAc) as well as reduced RSFC strength of dorsal prefrontal cortex (DLPFC)-caudate and orbitofrontal cortex (OFC)-NAc. NAc volumes were positively correlated with internet addiction test scores in IGD. The caudate volume and DLPFC-caudate RSFC was correlated with the impaired cognitive control (more incongruent errors in Stroop task) in IGD. Consistent with substance use disorder (SUD) findings, we detected striatum volume and frontostriatal circuits RSFC differences between IGD and healthy controls, which provided evidence of some degree of the similarity between IGD and SUD. More importantly, the cognitive control deficits in IGD were correlated with the reduced frontostrital RSFC strength. It is hoped that our results could shed insight on the neurobiological mechanisms of IGD and suggest potential novel therapeutic targets for treatment.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Frontostriatal circuits, resting state functional connectivity and cognitive control in internet gaming disorder

et al. 2016

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“…Although DTI studies have demonstrated WM integrity impairments in IGD adolescents compared with HCs (Dong, DeVito, Huang, & Du, 2012;Jeong, Han, Kim, Lee, & Renshaw, 2016;Lin et al, 2012;Weng et al, 2013;Xing et al, 2014;Yuan et al, 2011Yuan et al, , 2016, the relationship between impulsivity and WM integrity in IGD adolescents is largely unknown. The previous studies revealed that behavioral addiction is similar to substance addiction in terms of neuropsychology and neurophysiology (Alavi et al, 2012).…”

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confidence: 99%

Diffusion tensor imaging of the structural integrity of white matter correlates with impulsivity in adolescents with internet gaming disorder

Liu

Yang

et al. 2017

Brain and Behavior

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“…Cognitive control deficits in young smokers were measured by Stroop color‐word test as described in our previous studies [Cai et al, ; Feng et al, ; Xing et al, ; Yuan et al, a, b]. The task employed a block design with three conditions: congruent, incongruent, and rest.…”

Section: Methodsmentioning

confidence: 99%

The implication of frontostriatal circuits in young smokers: A resting-state study

Yuan

et al. 2016

Hum. Brain Mapp.

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The critical roles of frontostriatal circuits had been revealed in addiction. With regard to young smokers, the implication of frontostriatal circuits resting-state functional connectivity (RSFC) in smoking behaviors and cognitive control deficits remains unclear. In this study, the volume of striatum subsets, i.e., caudate, putamen, and nucleus accumbens, and corresponding RSFC differences were investigated between young smokers (n1 = 60) and nonsmokers (n2 = 60), which were then correlated with cigarette smoking measures, such as pack_years-cumulative effect of smoking, Fagerström Test for Nicotine Dependence (FTND)-severity of nicotine addiction, Questionnaire on Smoking Urges (QSU)-craving state, and Stroop task performances. Additionally, mediation analysis was carried out to test whether the frontostriatal RSFC mediates the relationship between striatum morphometry and cognitive control behaviors in young smokers when applicable. We revealed increased volume of right caudate and reduced RSFC between caudate and dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex in young smokers. Significant positive correlation between right caudate volume and QSU as well as negative correlation between anterior cingulate cortex-right caudate RSFC and FTND were detected in young smokers. More importantly, DLPFC-caudate RSFC strength mediated the relationship between caudate volume and incongruent errors during Stroop task in young smokers. Our results demonstrated that young smokers showed abnormal interactions within frontostriatal circuits, which were associated with smoking behaviors and cognitive control impairments. It is hoped that our study focusing on frontostriatal circuits could provide new insights into the neural correlates and potential novel therapeutic targets for treatment of young smokers. Hum Brain Mapp 37:2013-2026, 2016. © 2016 Wiley Periodicals, Inc.

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Reduced fiber integrity and cognitive control in adolescents with internet gaming disorder

Cited by 61 publications

References 45 publications

Frontostriatal circuits, resting state functional connectivity and cognitive control in internet gaming disorder

Frontostriatal circuits, resting state functional connectivity and cognitive control in internet gaming disorder

Diffusion tensor imaging of the structural integrity of white matter correlates with impulsivity in adolescents with internet gaming disorder

The implication of frontostriatal circuits in young smokers: A resting-state study

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