Reduced frontotemporal perfusion in psychopathic personality

Söderström, Henrik; Hultin, Leif; Tullberg, Mats; Wikkelsø, Carsten; Ekholm, Sven; Forsman, Anders

doi:10.1016/s0925-4927(02)00006-9

Cited by 115 publications

(83 citation statements)

References 25 publications

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“…Finally, a recent SPECT study in violent offenders institutionalized in a psychiatric facility found that the interpersonal factor, but not the social deviance factor, of psychopathy was negatively correlated with perfusion in the temporal lobe and the orbital frontal cortex (Soderstrom et al, 2002). This was the first study to examine the factors of psychopathy and measures of hemodynamic activity.…”

Section: Attention and Orienting Processes In Psychopathsmentioning

confidence: 86%

“…This model includes facets labeled, Interpersonal (Factor 1), Affective (Factor 2), Lifestyle (Factor 3), and Antisocial (Factor 4) (but see also Cooke and Michie, 1997, for a three-factor model). There have been few studies that have examined the neurocognitive correlates of the factor models of psychopathy (Patrick et al, 1993Raine et al, 2004;Soderstrom et al, 2002;Sutton et al, 2002). However, as in complex disorders such as schizophrenia, relating specific symptom clusters to patterns of cerebral activity may clarify the relevant brain disturbances and help reconcile discrepant findings (Liddle, 2001).…”

Section: The Construct and Assessment Of Psychopathymentioning

confidence: 99%

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A cognitive neuroscience perspective on psychopathy: Evidence for paralimbic system dysfunction

Kiehl

2006

Psychiatry Research

462

398

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Psychopathy is a complex personality disorder that includes interpersonal and affective traits such as glibness, lack of empathy, guilt or remorse, shallow affect, and irresponsibility, and behavioral characteristics such as impulsivity, poor behavioral control, and promiscuity. Much is known about the assessment of psychopathy; however, relatively little is understood about the relevant brain disturbances. The present review integrates data from studies of behavioral and cognitive changes associated with focal brain lesions or insults and results from psychophysiology, cognitive psychology and cognitive and affective neuroscience in health and psychopathy. The review illustrates that the brain regions implicated in psychopathy include the orbital frontal cortex, insula, anterior and posterior cingulate, amygdala, parahippocampal gyrus, and anterior superior temporal gyrus. The relevant functional neuroanatomy of psychopathy thus includes limbic and paralimbic structures that may be collectively termed 'the paralimbic system'. The paralimbic system dysfunction model of psychopathy is discussed as it relates to the extant literature on psychopathy.

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Section: Attention and Orienting Processes In Psychopathsmentioning

confidence: 86%

Section: The Construct and Assessment Of Psychopathymentioning

confidence: 99%

A cognitive neuroscience perspective on psychopathy: Evidence for paralimbic system dysfunction

Kiehl

2006

Psychiatry Research

462

398

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“…The function problems involved may be due to primary amygdala dysfunction [11,80,75] or abnormal functioning in the limbic circuitry [42,69]. Recent functional MRI studies have shown that individuals with PCL-R-rated psychopathy have abnormal affective memory activation in the limbic system (cingulum, ventral striatum, amygdala/hippocampal formation, and parahippocampal gyri) and increased cortical activity in other frontotemporal areas [40], and that a similar group have deviant activation patterns in the right prefrontal areas, amygdala, subgenual cingulate and temporal gyrus, and in the left-sided dorsal cingulate and parahippocampal gyrus when shown negative affective pictures [49].…”

mentioning

confidence: 99%

Central nervous changes in social dysfunction: Autism, aggression, and psychopathy

Anckarsäter

2006

Brain Research Bulletin

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Neurodevelopmental disorders such as autism and schizophrenia involve social interaction problems and poor mentalizing abilities, associated with abnormal regional cerebral activity.Similar problems may be present in aggressive personality disorders and psychopathy. This paper reviews brain imaging data from research aiming at establishing possible central nervous correlates to aggression and psychopathy. Studies in this field are associated with a range of method problems. Differences between criminal offenders and controls may be confounded by a number of factors unrelated to personality traits or aggression per se.Phenotypical characterisation varies between studies as do the laboratory methods and their interpretation. In spite of these problems, there are some recurrent findings in the present literature. Hypoactivity or structural reduction of the prefrontal cortex is a consistent finding in violent offenders or subjects with antisocial personality disorder. When defined as a personality disorder of social interaction and empathy, psychopathy seems to be associated rather with central abnormalities in the limbic circuitry. Indications of an increased dopaminergic neurotransmission relative to the serotonergic have also been connected to such personality traits, especially to the AD/HD-related behavioural aspects. Further studies using strict phenotypical definitions or experimental models are clearly warranted to establish a pathophysiological background to destructive personality traits and the propensity to violent acting out.

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“…No new structural pathology was shown by MRI, including T1-and T2-weighted sequences (Soderstrom et al, 2002). The mean (± standard deviations) ratios between baseline and follow-up rrCBF are depicted for all ROIs in Figure 1.…”

Section: Resultsmentioning

confidence: 97%

“…All SPECT examinations were performed according to the same protocol as that used in the initial studies (Soderstrom et al, 2000 and2002). A standard dose of 1000 MBq radioactive blood flow marker ([99mTc]-d, I-HMPAO) was administered intravenously during rest with closed eyes.…”

Section: Methodsmentioning

confidence: 99%

Persistent regional frontotemporal hypoactivity in violent offenders at follow-up

Anckarsäter¹,

Piechnik²,

Tullberg³

et al. 2007

Psychiatry Research: Neuroimaging

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Since cross-sectional brain imaging studies demonstrating frontotemporal cerebral hypoactivity in violent offenders have generally been carried out around the time of trial and sentencing, the findings might be influenced by the stressful situation of the subjects. It seems that no group of offenders with this finding has been followed longitudinally so far. We have re-examined nine offenders convicted of lethal or nearlethal violence in whom single photon emission tomography (SPECT) previously had demonstrated frontotemporal hypoperfusions. The mean interval between the initial and the follow-up examination was 4 years. The initially observed hypoactivity was found to have remained virtually unchanged at follow-up: no mean change in the group exceeded 5 % in 12 assessed regions of interest. Although preliminary due to the small sample size, this study suggests that frontotemporal brain hypoactivity is a trait rather than a state in perpetrators of severe violent crimes.

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Reduced frontotemporal perfusion in psychopathic personality

Cited by 115 publications

References 25 publications

A cognitive neuroscience perspective on psychopathy: Evidence for paralimbic system dysfunction

A cognitive neuroscience perspective on psychopathy: Evidence for paralimbic system dysfunction

Central nervous changes in social dysfunction: Autism, aggression, and psychopathy

Persistent regional frontotemporal hypoactivity in violent offenders at follow-up

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