Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination

Mental health in the UK Biobank: a roadmap to self-report measures and neuroimaging correlates

“…However, the literature on neural correlates of MDD contains some inconsistent findings. For example, some studies report greater functional connectivity in the DMN [Greicius et al, 2007;Sheline et al, 2010] while others report lesser functional connectivity in the same network [Bluhm et al, 2009;Tozzi et al, 2021;Yan et al, 2019]. A potential reason for inconsistent findings is the small sample size of most of these studies.…”

“…One limitation of these studies is their small sample sizes, which has likely contributed to inconsistent and sometimes contradictory findings across different studies. For example, some studies report greater functional connectivity in the DMN [Greicius et al, 2007; Sheline et al, 2010] while others report lesser functional connectivity in the network [Bluhm et al, 2009; Tozzi et al, 2021; Yan et al, 2019]. Importantly, studies with low statistical power may not reflect true effects and may result in inflated brain-behavior correlations [Button et al, 2013; Marek et al, 2020].…”

“…Additionally, due to the lack of availability of whole brain statistical result images from prior studies, coordinate-based meta-analyses are often undertaken which are limited in their spatial precision [Müller et al, 2018]. These inherent limitations of meta-analyses may explain why disagreement persists within even meta-analytical work, with a recent study showing hypo- (rather than hyper-) connectivity in the core DMN in patients with depression [Tozzi et al, 2021].…”

“…Over the years there have been a multitude of neuroimaging studies that aimed to investigate alterations in the brain in relation to affect-based mental health (e.g., anxiety and depression). The Major Depressive Disorder (MDD) literature reports structural changes in the cortico-limbic network [Klauser et al, 2015], insula and hippocampus [Stratmann et al, 2014], as well as functional changes in the Default Mode Network (DMN) [Tozzi et al, 2021;Yu et al, 2019], medial temporal gyrus, and caudate [Ma et al, 2012]. In Generalized Anxiety Disorder (GAD), similar functional changes are seen in the DMN [Andreescu et al, 2011] and ventromedial prefrontal cortex [Cha et al, 2014], as well as structural changes in the DMN [Wolf et al, 2016] and amygdala [He et al, 2016].…”

Plasma NFL Disrupt Cognitive Integrity Via Coupling the Interactions of Core Subsystem and Frontoparietal Network in Alzheimer's Disease

“…The MTL subsystem includes the ventral medial prefrontal cortex (vMPFC), posterior inferior parietal lobule, retrosplenial cortex, parahippocampal cortex and hippocampal formation, which is associated with memory processes, such as episodic memory retrieval [7]. Importantly, converging evidences have revealed that the core subsystem is proposed to be the hub linking the other two subsystems together, as well as the functional connectivity of the core subsystem is dependent of the disease which including the anterior medial prefrontal cortex (amPFC) and the posterior cingulate cortex (PCC) [6,[8][9][10]. Furthermore, our previous study has demonstrated that the core subsystem-centered connection abnormalities were associated with the progress of cognitive impairments in AD-spectrum patients [8].…”