Reduced incidence of Type 1 diabetes and Type 2 diabetes in systemic sclerosis: A nationwide cohort study

Tseng, Chia‐Chun; Chang, Shun‐Jen; Tsai, Wen‐Chan; Ou, Tsan‐Teng; Wu, Chuan-Chun; Sung, Wan‐Yu; Hsieh, Ming‐Chia; Yen, Jeng‐Hsien

doi:10.1016/j.jbspin.2015.06.017

Cited by 11 publications

(5 citation statements)

References 34 publications

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“…Interestingly, in a large Australian cohort, Ngian et al [ 19 ] found a lower prevalence of T2D in SSc patients than in controls drawn from a national, longitudinal, population-based study. Consistently, in a retrospective cohort study, Tseng et al [ 20 ] demonstrated a reduced incidence of T2D in SSc in both sexes compared to controls. These results were further corroborated by Ursini et al [ 21 ] who confirmed a significantly lower prevalence of T2D in SSc than in the general Italian population.…”

Section: Introductionsupporting

confidence: 57%

Whole body insulin sensitivity is increased in systemic sclerosis

et al. 2023

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Objectives In the present study, we aimed to evaluate whole-body insulin sensitivity in systemic sclerosis (SSc) patients and to compare the results with controls with no autoimmune rheumatic disease (non-ARD) and with patients affected by rheumatoid arthritis (RA). Methods In all patients and controls, oral glucose tolerance test (OGTT) was performed according to the World Health Organization (WHO) recommendations. Plasma glucose and insulin concentrations were measured at time 0 and then after 30, 60, 90, and 120 minutes. Whole-body insulin sensitivity (ISI), insulinogenic index (IGI), oral disposition index (ODI), and insulin resistance (HOMA-IR) were estimated accordingly. Results A total of 41 SSc patients were evaluated and, for comparison, 41 individuals with RA and 82 non-ARD control patients were recruited. OGTT yielded a proportion of normotolerant individuals among SSc patients higher than in RA controls (p = 0.040) but lower than in the non-ARD group (p = 0.028). The ISI was significantly higher in SSc patients compared with RA controls (p <0.001) and with non-ARD patients (p <0.001). Significant differences emerged also when analysing the HOMA-IR, which was lower in SSc patients than in RA (p <0.001) and non-ARD (p <0.001) groups. Additionally, IGI was lower in SSc patients compared with RA (p = 0.011) and with non-ARD controls (p <0.001), whereas ODI was not significantly different between groups. Conclusions Interestingly, we found that SSc patients are more insulin sensitive than those with RA and even than individuals without inflammatory diseases. In contrast, no significant difference was found in terms of β-cell function.

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Section: Introductionsupporting

confidence: 57%

Whole body insulin sensitivity is increased in systemic sclerosis

et al. 2023

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“…Several diseases were found to be associated with a greater prevalence of both diagnosed and undiagnosed diabetes, such as PCOS [ 20 – 22 ]. Other diseases, for converse, are characterized by a reduced prevalence of diabetes [ 23 , 24 ]. Third, no information is provided for current or past treatment, diabetogenic medications such as corticosteroids and protective medications such as biologics.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of diabetes and unrecognized diabetes in hypertensive patients aged 40 to 79 years in southwest China

et al. 2017

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This study aimed to assess the prevalence of diabetes and unrecognized diabetes in hypertensive patients aged 40 to 79 years in Southwest China. From September 2013 to March 2014, a cross-sectional survey was conducted in 4021 hypertensive patients aged 40 to 79 years living in Chengdu and Chongqing, China. Fasting plasma glucose (FPG) and 2h plasma glucose (2-hPG) in an oral glucose-tolerance test (OGTT) were used for assessments. Whether the patients previously had diabetes (DM) was determined by their own reports. The survey was carried out by the same questionnaire for all respondents. DM prevalence was 32.0% in hypertensive patients aged 40 to 79 years in Southwest China, with the rates of 29.6% and 33.5% in men and women, respectively (P<0.001). DM prevalence increased with age age and body-mass index. DM prevalence rates were 16.9%, 24.7%, 38.2% and 41.9% in hypertensive patients aged 40–49, 50–59, 60–69 and over 70, respectively. DM prevalence were 30.6%, 27.9%, 37.1%, and 37.4%, for BMI<18.5, 18.5–24.9, 25.0–29.9, and ≥30, respectively. Prevalence of unrecognized DM were 20.8% in hypertensive patients aged 40 to 79 years in Southwest China. Using only fasting blood glucose testing without OGTT would have resulted in 65.0% of missed DM diagnosis in these newly diagnosed patients. The prevalence of DM and unrecognized DM were high in hypertensive patients aged 40 to 79 years in Southwest China.These findings indicate that hypertensive patients aged 40 to 79 years should regularly submit to community-based OGTT screening for timely DM diagnosis.

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“…We read with interest the article by Tseng et al [1] that described a low incidence of type 2 diabetes (T2DM) in systemic sclerosis (SSc), a finding matching previous studies suggesting a reduced prevalence [2]. However this study, although describing large administrative data from a health insurance cohort, did not explored the correlation between T2DM and body mass index (BMI) or other disease-related variables.…”

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confidence: 82%